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The document concludes that managing PCOS requires a comprehensive approach, including lifestyle changes and medication, to improve symptoms and reduce health risks.

Testosterone replacement therapy helps manage deficiency and has various methods, but requires careful monitoring to avoid side effects.

Removing myelin protein zero-like 3 in mice leads to better metabolism and resistance to obesity.

Blocking the ATX-LPA pathway may improve insulin sensitivity and mitochondrial function in obesity.

Nanotechnology shows promise for better drug delivery and cancer treatment.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

Low selenium levels can extend lifespan but worsen health issues.

High levels of male hormones in pregnant mice cause heart enlargement and poor heart function in their female babies.

Vertical sleeve gastrectomy improved metabolism, behavior, and reproduction in obese rats with PCOS.

The new rodent model successfully mimics non-lean human PCOS symptoms.

Exercise improves insulin sensitivity and hormone regulation in PCOS rats.

Melatonin may help treat PCOS symptoms in rats.

Exercise and finasteride together improve ovary health in PCOS rats.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

The hydrogel made of chitosan, HPMC, and insulin speeds up wound healing and could be a new dressing, especially for diabetics.

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

Pioglitazone improved insulin sensitivity and altered cortisol metabolism in PCOS patients.

Children with classic congenital adrenal hyperplasia have thicker heart fat and are at higher risk for heart problems and early atherosclerosis.

Children with classic congenital adrenal hyperplasia have thicker heart fat and more heart and blood vessel risk factors, especially if their condition is not well-controlled.

Men with early balding should be checked for metabolic syndrome, as there's a link between the two.

Androgens and androgen receptors are important for metabolic health, affecting how the body uses glucose and fats through mitochondrial function.

Women with irregular periods and/or excessive body hair are more likely to have polycystic ovaries, and this condition is linked to higher health risks.

An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.

A mix of Panax ginseng and bee-pollen may help prevent prostate enlargement in rats.

Genetically modified stem cells from human hair follicles can lower blood sugar and increase survival in diabetic mice.

Long-term use of dutasteride for enlarged prostate may worsen blood sugar, cholesterol, and erectile dysfunction.

Prenatally androgenized ewes can model increased hair diameter in women with PCOS.

PCOS affects many women, causing various symptoms and health risks, and is managed through lifestyle changes, medication, and support groups.

Chinese women with PCOS have higher androgen levels, which change with age and weight.

Treating early puberty with hormone therapy may increase the risk of polycystic ovary syndrome in adults.