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Surgery for high-risk prostate cancer is challenging but doesn't lead to more complications, and additional treatment is often needed.

The document concludes that accurate diagnosis and understanding the type of hair disorder are crucial for treating hair loss in children.

Most women with excessive hair growth have a hormonal cause.

Pilocarpin can cause hair regrowth and color change in some cases but not in others, and it may have side effects in animals.

The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

Polycystic Ovary Syndrome should be seen mainly as a condition of excess male hormones, with a focus on this in its definition.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

Women with PCOS should be screened for heart disease risk and manage their health to prevent it.

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

Terazosin and finasteride effectively treat BPH, but combining them adds no extra benefit.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Fat-related cells are important for initiating hair growth.

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.

Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

The guidelines suggest lifestyle changes, diet adjustments, and personalized medication to manage dyslipidemia and reduce heart disease risk.

DNA profiling in forensics has improved, but predicting physical traits and ancestry from DNA has limitations and requires ethical consideration.

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

Air pollution worsens skin diseases and aging by causing inflammation and oxidative stress.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

The document concludes that the fast-growing direct-to-consumer genetic testing market lacks sufficient regulation, posing risks to consumers due to questionable test quality and accuracy.

A protein from certain immune cells is key for new hair growth after skin injury in mice.

Stem cells are crucial for skin repair and new treatments for chronic wounds.

Hormone therapy for trans individuals is effective and generally safe in the short term.