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    Glossary Facial Aging

    natural changes in skin, muscles, and bones over time

    Facial aging, also known as age-related facial changes or facial senescence, refers to the natural process by which the skin, muscles, fat, and bones of the face undergo changes over time. This includes the development of wrinkles, loss of skin elasticity, volume loss in the cheeks and temples, and changes in facial contours due to the resorption of bone and redistribution of fat. These changes are influenced by a combination of genetic factors, environmental exposures, and lifestyle choices.

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    1. Facial skin aging: an integrative analysis of genetics, epigenetics, and lifestyle factors GeroScience · 2025
    2. Facial Skin Aging: a multidimensional phenotype RePub (Erasmus University, Rotterdam) · 2020
    3. Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro‐collagen lipopeptide, creatine, and urea on skin aging signs Journal of Cosmetic Dermatology · 2015 · 36 citations
    4. DNA Methylation‐Regulated ZDHHC17 Promotes the Risk of Facial Skin Aging Clinical Cosmetic and Investigational Dermatology · 2025
    5. Niacinamide: A B Vitamin that Improves Aging Facial Skin Appearance Dermatologic surgery · 2005 · 120 citations
    6. 23 Efficacy of combined treatment with adipose tissue stem cell exosomes (ASCE) and microneedling for facial skin aging: a 12-week prospective, randomized, split-face study 2023
    7. Ergothioneine, collagen peptides, and sodium hyaluronate ameliorate facial skin aging via modulating oxidative stress, inflammation, and extracellular matrix homeostasis Frontiers in Nutrition · 2026
    8. Effects of Glucagon-like Peptide-1 Receptor Agonists on Skin Homeostasis and Skin Aging Processes Journal of Clinical Medicine · 2026
    9. In search of a universal and objective method to assess facial aging: The new face objective photo-numerical assessment scale Journal of Cranio-Maxillofacial Surgery · 2019 · 68 citations
    10. A single center, pilot, double-blinded, randomized, comparative, prospective clinical study to evaluate improvements in the structure and function of facial skin with tazarotene 0.1% cream alone and in combination with GliSODin® Skin Nutrients Advanced A Clinical Cosmetic and Investigational Dermatology · 2014 · 9 citations
    11. A Comparative Study on Adipose-Derived Mesenchymal Stem Cells Secretome Delivery Using Microneedling and Fractional CO2 Laser for Facial Skin Rejuvenation [Response to Letter] Clinical Cosmetic and Investigational Dermatology · 2023
    12. Biological insights from self-perceived facial aging data of the UKBB participants bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 2 citations
    13. Innovations in Skin and Soft Tissue Aging—A Systematic Literature Review and Market Analysis of Therapeutics and Associated Outcomes Aesthetic Plastic Surgery · 2023 · 17 citations
    14. Look at Your Hair the Way You Look at Your Face: Concept of Total Facial Skin and Hair Care Skin Appendage Disorders · 2020 · 7 citations
    15. Age‐dependent changes in skin features and perceived facial appearance in women of five ethnic groups International Journal of Cosmetic Science · 2024 · 2 citations
    16. 1395 Impact of urban pollution on top of chronic sun-exposure on skin ageing in Chinese women Journal of Investigative Dermatology · 2023
    17. [Hormone replacement treatment and skin aging]. PubMed · 1996 · 16 citations
    18. A review of the role of estrogen in dermal aging and facial attractiveness in women Journal of cosmetic dermatology · 2018 · 58 citations
    19. The role and mechanism of adipose stem cells in facial anti-aging Theoretical and Natural Science · 2023
    20. Gender‐related cost discrepancies in a cohort of 110 facial moisturizers Journal of Cosmetic Dermatology · 2019 · 3 citations
    21. Lifestyle and Physiological Factors Associated with Facial Wrinkling in Men and Women Journal of Investigative Dermatology · 2017 · 24 citations
    22. The Aging Face Medical Clinics of North America · 2018 · 22 citations
    23. HA Filler Injection and Skin Quality–Literature Minireview and Injection Techniques 2020 · 10 citations
    24. Exploring the Cosmetic Benefits of Moringa Powder: A Natural Solution for Skin and Hair Care International Journal For Multidisciplinary Research · 2024
    25. Aging in the Male Face: Intrinsic and Extrinsic Factors Dermatologic Surgery · 2016 · 27 citations
    26. Surgery of the Skin JAMA · 1998
    27. Extracellular Vesicles in Facial Aesthetics: A Review International Journal of Molecular Sciences · 2022 · 8 citations
    28. The Effects of an Oral Supplementation of a Natural Keratin Hydrolysate on Skin Aging: A Randomized, Double‐Blind, Placebo‐Controlled Clinical Study in Healthy Women Journal of Cosmetic Dermatology · 2024 · 4 citations
    29. The Effectiveness of a Topical Rosehip Oil Treatment on Facial Skin Characteristics: A Pilot Study on Wrinkles, UV Spots Reduction, Erythema Mitigation, and Age-Related Signs Cosmetics · 2025 · 2 citations
    30. Differences in Perceptions of Beauty and Cosmetic Procedures Performed in Ethnic Patients Seminars in Cutaneous Medicine and Surgery · 2009 · 49 citations