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    Glossary Facial Aging

    natural changes in skin, muscles, and bones over time

    Facial aging, also known as age-related facial changes or facial senescence, refers to the natural process by which the skin, muscles, fat, and bones of the face undergo changes over time. This includes the development of wrinkles, loss of skin elasticity, volume loss in the cheeks and temples, and changes in facial contours due to the resorption of bone and redistribution of fat. These changes are influenced by a combination of genetic factors, environmental exposures, and lifestyle choices.

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    1. In search of a universal and objective method to assess facial aging: The new face objective photo-numerical assessment scale Journal of Cranio-Maxillofacial Surgery · 2019 · 68 citations
    2. Biological insights from self-perceived facial aging data of the UKBB participants bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 2 citations
    3. Facial skin aging: an integrative analysis of genetics, epigenetics, and lifestyle factors GeroScience · 2025
    4. Facial Skin Aging: a multidimensional phenotype RePub (Erasmus University, Rotterdam) · 2020
    5. Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro‐collagen lipopeptide, creatine, and urea on skin aging signs Journal of Cosmetic Dermatology · 2015 · 36 citations
    6. DNA Methylation‐Regulated ZDHHC17 Promotes the Risk of Facial Skin Aging Clinical Cosmetic and Investigational Dermatology · 2025
    7. The role and mechanism of adipose stem cells in facial anti-aging Theoretical and Natural Science · 2023
    8. A review of the role of estrogen in dermal aging and facial attractiveness in women Journal of cosmetic dermatology · 2018 · 58 citations
    9. A comparison of self-reported signs of facial aging among women in Australia vs. those in the United States, United Kingdom, and Canada Journal of The American Academy of Dermatology · 2017
    10. Niacinamide: A B Vitamin that Improves Aging Facial Skin Appearance Dermatologic surgery · 2005 · 120 citations
    11. Comprehensive Facial Rejuvenation: A Practical and Systematic Guide to Surgical Management of the Aging Face Archives of Facial Plastic Surgery · 2004
    12. Associations between genetically predicted sex and growth hormones and facial aging in the UK Biobank: a two−sample Mendelian randomization study Frontiers in endocrinology · 2023 · 1 citations
    13. Ergothioneine, collagen peptides, and sodium hyaluronate ameliorate facial skin aging via modulating oxidative stress, inflammation, and extracellular matrix homeostasis Frontiers in Nutrition · 2026
    14. 23 Efficacy of combined treatment with adipose tissue stem cell exosomes (ASCE) and microneedling for facial skin aging: a 12-week prospective, randomized, split-face study 2023
    15. The Facial Adipose Tissue: A Revision Facial plastic surgery · 2016 · 69 citations
    16. Aging in the Male Face: Intrinsic and Extrinsic Factors Dermatologic Surgery · 2016 · 27 citations
    17. The Aging Face Medical Clinics of North America · 2018 · 22 citations
    18. Innovations in Skin and Soft Tissue Aging—A Systematic Literature Review and Market Analysis of Therapeutics and Associated Outcomes Aesthetic Plastic Surgery · 2023 · 17 citations
    19. Effects of Glucagon-like Peptide-1 Receptor Agonists on Skin Homeostasis and Skin Aging Processes Journal of Clinical Medicine · 2026
    20. Look at Your Hair the Way You Look at Your Face: Concept of Total Facial Skin and Hair Care Skin Appendage Disorders · 2020 · 7 citations
    21. Periorbital facial rejuvenation; applied anatomy and pre-operative assessment journal of current ophthalmology · 2017 · 36 citations
    22. Lifestyle and Physiological Factors Associated with Facial Wrinkling in Men and Women Journal of Investigative Dermatology · 2017 · 24 citations
    23. A single center, pilot, double-blinded, randomized, comparative, prospective clinical study to evaluate improvements in the structure and function of facial skin with tazarotene 0.1% cream alone and in combination with GliSODin® Skin Nutrients Advanced A Clinical Cosmetic and Investigational Dermatology · 2014 · 9 citations
    24. Gender‐related cost discrepancies in a cohort of 110 facial moisturizers Journal of Cosmetic Dermatology · 2019 · 3 citations
    25. Age‐dependent changes in skin features and perceived facial appearance in women of five ethnic groups International Journal of Cosmetic Science · 2024 · 2 citations
    26. A Comparative Study on Adipose-Derived Mesenchymal Stem Cells Secretome Delivery Using Microneedling and Fractional CO2 Laser for Facial Skin Rejuvenation [Response to Letter] Clinical Cosmetic and Investigational Dermatology · 2023
    27. 1395 Impact of urban pollution on top of chronic sun-exposure on skin ageing in Chinese women Journal of Investigative Dermatology · 2023
    28. Endoscopic assisted facial rejuvenation: a 35 year personal journey Plastic and Aesthetic Research · 2020
    29. A New Paradigm for the Aging Face Facial Plastic Surgery Clinics of North America · 2010 · 16 citations
    30. [Hormone replacement treatment and skin aging]. PubMed · 1996 · 16 citations