research The Thinning Top: Why Older People Have Less Hair
Old people have less hair because their hair follicles don't regenerate as well, not because of fewer stem cells, and a protein called follistatin might help reactivate hair growth.
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research Hematopoietic Stem Cells: Nature and Niche Nurture
Blood stem cells are diverse, influenced by many factors, and understanding them is key for progress in regenerative medicine.
research Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin
The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.
research Removing All Obstacles: A Critical Role for p53 in Promoting Tissue Renewal
The gene p53 is crucial for removing damaged cells to allow for healthy tissue renewal.
research The Genetically Programmed Hair Growth Cycle And Alopecia: What Is There To Know?
The document concludes that hair loss is complex, affects many people, has limited treatments, and requires more research on its causes and psychological impact.
research Novel Approaches to Characterize Age-Related Remodeling of the Dermal-Epidermal Junction in 2D, 3D, and In Vivo
3D imaging shows clearer details of skin structure changes with age.
research Microneedling and Oral Collagen Replacement as Strategies for Skin Rejuvenation
Microneedling with oral collagen improves wrinkles better than microneedling alone.
research Hair Follicles as a Critical Model for Monitoring the Circadian Clock
Hair follicles could be used to noninvasively monitor our body's internal clock and help identify risks for related diseases.
research Platelet-Rich Plasma and Genital Rejuvenation
Platelet-rich plasma may be effective for genital rejuvenation and deserves more research.
research Apoptosis in Hair and Skin: A Review
The study concludes that regulating apoptosis could lead to new treatments for various skin and hair conditions.
research Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature
Mitochondrial dysfunction is linked to various skin conditions and could be a target for treatments.
research Irradiation-Induced Hair Graying in Mice: An Experimental Model to Evaluate the Effectiveness of Interventions Targeting Oxidative Stress, DNA Damage Prevention, and Cellular Senescence
Using radiation to make mice's hair turn gray helps study and find ways to prevent or reverse hair graying.
research Emerging Trends and Focus in Human Skin Microbiome Over the Last Decade: A Bibliometric Analysis and Literature Review
Research on the human skin microbiome has grown, focusing on skin health and diseases, with more studies needed on antibiotic resistance and AI applications.
research Hydrobiome Of Thermal Waters: Potential Use In Dermocosmetics
Thermal spring waters and their microbes could be good for skin health and treating some skin conditions in skincare products.
research EEMCO Guidance for the Assessment of Hair Shedding and Alopecia
The document explains hair growth and shedding, factors affecting it, and methods to evaluate hair loss, emphasizing the importance of skin biopsy for diagnosis.
research The Stem Cell Niche in Regenerative Medicine
Targeting and modifying the stem cell niche can improve regenerative therapies.
research Type XVII collagen coordinates proliferation in the interfollicular epidermis
The study identified Type XVII collagen (COL17) as a crucial regulator of epidermal cell proliferation in the interfollicular epidermis (IFE) of both neonatal and aged mice. In neonatal mice, the absence of COL17 led to transient hyperproliferation due to disrupted Wnt signaling, which was reversible by replenishing COL17. In aged skin, loss of COL17 caused by inactive atypical protein kinase C signaling resulted in hyperproliferation, which could be suppressed by overexpressing human COL17. The research highlighted COL17's role in maintaining skin homeostasis and suggested its potential as a target for anti-aging treatments. However, the study faced limitations, including discrepancies between in vitro and in vivo results and a small sample size of patients with COL17A1 mutations, indicating a need for further investigation.
research Over- And Ectopic-Expression Of FoxN1 At Early Life Adversely Influences Lymphopoiesis
Early over-expression of FoxN1 harms immune and skin development.
research Topical and Nutricosmetic Products for Healthy Hair and Dermal Anti-Aging Using Dual-Acting Plant-Based Peptides, Hormones, and Cannabinoids
Plant-based products can improve hair and skin health without harmful side effects.
research Dysregulated Behavior of Hair Follicle Stem Cells Triggers Alopecia and Provides Potential Therapeutic Targets
Misbehaving hair follicle stem cells can cause hair loss and offer new treatment options.
research Exosomes Derived Stem Cells as a Modern Therapeutic Approach for Skin Rejuvenation and Hair Regrowth
Exosomes from stem cells may help rejuvenate skin and regrow hair, but more research is needed.
research Author response: Type XVII collagen coordinates proliferation in the interfollicular epidermis
The study investigated the role of Type XVII collagen (COL17) in the interfollicular epidermis (IFE), focusing on its potential as an anti-aging molecule and its regulation of proliferation through Wnt signaling. It was found that loss of COL17 led to hyperproliferation and altered Wnt signaling, with aging also reducing COL17 levels and causing similar effects. However, reviewers noted concerns about the strength of the link between Wnt signaling and the observed phenotype, the transient nature of hyperproliferation in mice compared to humans, and speculative discussions on COL17's role in oncogenesis. Discrepancies between in vivo and in vitro findings were highlighted, and further validation was suggested to clarify these observations before publication.
research Decision letter: Type XVII collagen coordinates proliferation in the interfollicular epidermis
The study examined the role of Type XVII collagen (COL17) in the regulation of interfollicular epidermis (IFE) homeostasis and its connection to Wnt signaling, with implications for skin aging. It found that COL17 deficiency led to transient hyperproliferation in neonatal mice, which decreased over time, and suggested a potential anti-aging role for COL17. However, the study faced criticism for the weak link between Wnt signaling and the observed phenotype, the transient nature of hyperproliferation, and discrepancies between in vivo and in vitro findings. Despite its high quality, the study required further validation and additional experiments to strengthen its conclusions and clarify the role of COL17 in preventing oncogenesis.
research Emerging Interactions Between Skin Stem Cells and Their Niches
Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.
research Orchestration of Tissue-Scale Mechanics and Fate Decisions by Polarity Signaling
Cell polarity signaling controls tissue mechanics and cell fate, with complex interactions and varying pathways across species.
research Hair Lipid Structure: Effect of Surfactants
Surfactants in shampoos and conditioners remove some but not all lipids from hair, and more research is needed to understand their full impact.
research Stem Cells, Organoids and Their Applications for Human Diseases: Special Issue of BMB Reports in 2023
Organoids created from stem cells are used to model diseases, test drugs, and develop personalized and regenerative medicine.
research Spontaneous Lesions of Endangered Geriatric Julia Creek Dunnarts (Sminthopsis Douglasi, Archer 1979) with Emphasis on Reproductive Pathology
Geriatric Julia Creek dunnarts often suffer from reproductive and skin diseases, impacting conservation efforts.
research Effects of UV-Induced Photoaging on the Hair Follicle Cycle of C57BL6/J Mice
UV exposure causes hair thinning, graying, and changes in hair growth cycles in mice.
research Adipose Tissue Protects Against Skin Photodamage Through CD151- And AdipoQ- EVs
Fat tissue vesicles protect skin from UV damage better than stem cell vesicles.