February 2023 in “Frontiers in Pharmacology” This study found that the water extract of Cacumen Platycladi promotes hair growth and follicle development in mice, possibly by influencing dermal papilla cells through the Akt/GSK3β/β-Catenin signaling pathway.
January 2023 in “International Journal of Trichology” In a case series, this study reported significant hair regrowth in both men and women with androgenetic alopecia using a topical hemp extract high in CBD, THCV, and CBDV over six months.
June 2022 in “International journal of drug delivery technology” This study found that Convolvulus arvensis ethanolic extract may promote hair growth and reduce hair loss in albino mice with testosterone-induced baldness by increasing follicular density and the anagen/telogen ratio.
March 2022 in “Japanese Journal of Complementary and Alternative Medicine” In this case study, a novel treatment combining basal stone therapy and placenta extract applied to the scalp improved hair loss in a 46-year-old man resistant to typical home-care treatments for androgenic alopecia.
December 2019 in “Arak Medical University Journal” This study found that adding 7% chamomile extract to 5% minoxidil solution reduced cutaneous side effects like itching, scaling, and erythema in men with androgenic alopecia compared to using minoxidil alone.
November 2019 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that combining 7% chamomile extract with 5% minoxidil solution may reduce cutaneous side effects like itching, scaling, and erythema in male patients with androgenic alopecia, potentially improving treatment compliance.
March 2005 in “Journal of The American Academy of Dermatology” Herbal extract improves hair growth in female pattern baldness.
87 citations
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March 2005 in “Journal of Dermatological Science” This study found that the extract of Asiasari radix may promote hair growth in mice by enhancing protein synthesis, cell proliferation, and growth factor expression.
75 citations
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October 2002 in “Journal of Dermatological Science” This study found that Sophora flavescens extract may promote hair growth in mice by inducing earlier hair cycle changes and regulating growth factors in dermal papilla cells.
53 citations
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July 2021 in “International Journal of Molecular Sciences” This study found that extracts from Geranium pyrenaicum show promising antioxidant, enzyme inhibitory, and antiviral activities, particularly the methanolic extract's antiviral activity against HSV-1.
49 citations
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November 2014 in “Journal of Medicinal Food” In this study, red ginseng extract and its ginsenosides enhanced human hair follicle cell proliferation and countered dihydrotestosterone-induced suppression, suggesting potential to promote hair growth.
49 citations
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April 2012 in “Phytotherapy Research” This study found that topical Rosmarinus officinalis leaf extract improved hair regrowth in mice and inhibited androgen-associated mechanisms involved in hair loss.
36 citations
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February 2017 in “BMC Complementary and Alternative Medicine” In this study, Geranium sibiricum L. extract promoted hair growth in vitro with human dermal papilla cells and in vivo in mice, outperforming minoxidil by proliferating cells and stimulating growth factor expression, suggesting its potential as a hair growth treatment.
32 citations
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February 2020 in “PTR. Phytotherapy research/Phytotherapy research” This review examines studies on rosemary extracts for immune function, noting promising in vitro and animal evidence but highlighting a lack of human data.
32 citations
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December 2013 in “Biological & Pharmaceutical Bulletin” In this study, rice bran supercritical CO2 extract demonstrated potential to promote hair growth in mice, increasing hair follicles and growth factor expression, similarly to 3% minoxidil.
28 citations
,
July 2021 in “Pharmaceutics” This study found that Morus alba root extract activates β-catenin in hair follicle dermal papilla cells, promoting the transition to the anagen phase and enhancing hair growth factor secretion.
25 citations
,
August 2015 in “International Journal of Cosmetic Science” This study suggests that an extract from Malva verticillata seeds could help treat hair loss by modulating the Wnt/β-catenin pathway in cultured human dermal papilla cells.
25 citations
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July 2004 in “Experimental Dermatology” This study found that water-soluble extracts of Illicium anisatum promoted hair follicle elongation in cultured mouse vibrissae, suggesting potential use in hair growth products.
24 citations
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June 2021 in “Annals of Translational Medicine” This review discusses the potential of human placental extract (HPE) in cartilage regenerative medicine for osteoarthritis, noting its significant anti-inflammatory and regenerative properties observed in vitro and in vivo studies, but reports no new clinical results.
23 citations
,
January 2001 in “International journal of toxicology” This review discusses the cosmetic use and safety of Hypericum Perforatum Extract and Oil, finding that current data are insufficient to support their safety in formulations due to a lack of comprehensive testing.
22 citations
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August 2020 in “Molecules” This study found that applying AGN root extract containing decursin to mouse skin accelerated hair growth and altered inflammatory cytokine levels compared to a control.
22 citations
,
August 2015 in “PloS one” This study found that the binding and release of BMP-2 from kerateine biomaterials are significantly influenced by pH and salt concentration, highlighting the potential for developing improved bone repair systems.
22 citations
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August 2011 in “Journal of Supercritical Fluids” In this study, fraction No. 3 of Oryza sativa bran extract demonstrated high unsaturated fatty acid content and significant 5α-reductase inhibition, suggesting potential for developing anti-androgenic alopecia products.
22 citations
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January 2011 in “Indian Journal of Dermatology/Indian journal of dermatology” This study found that cow placenta extract increased hair follicle size and hair length in mice but was less effective than minoxidil, suggesting potential with further refinement.
22 citations
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August 2009 in “Evidence-based Complementary and Alternative Medicine” This study found that a composition including Serenoa repens extract and anti-inflammatory agents effectively suppressed inflammation-related gene expression in a keratinocyte model, suggesting a potential dual strategy for treating androgenetic alopecia.
22 citations
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March 2009 in “Journal of Natural Medicines” This study found that Erica multiflora extract promotes hair growth by enhancing dermal papilla cell activity and shifting hair follicles from the telogen to the anagen phase in both in vitro and in vivo models.
21 citations
,
February 2023 in “Pharmaceuticals” This study reports that extracts from pomegranate leaves contain bioactive compounds with antioxidant, antimicrobial, and skin-beneficial properties, suggesting their potential use in nutraceutical and cosmeceutical applications.
20 citations
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February 2018 in “Cell transplantation” This study found that the water extract of Cinnamomum osmophloeum Kanehira leaves enhanced hair growth in vitro and in a mouse model, suggesting potential use for treating hair loss.
20 citations
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January 2017 in “Nutrition Research and Practice” In this study, corn silk extract treatment improved symptoms of testosterone-induced BPH by reducing specific mRNA expression and decreasing levels of 5α-R2, DHT, and PSA.
19 citations
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December 2013 in “European journal of pharmaceutics and biopharmaceutics” This study found that encapsulated Garcinia mangostana Linn extract in a cream base penetrated more deeply and homogeneously into porcine ear skin compared to other formulations.