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This review suggests that omitting the proteolysis step and including tissue pieces in mesenchymal stem cell isolation may improve cell quality, reduce contamination risk, and lower costs and processing time in clinical applications.

This study found that explant transfers of human umbilical cord Wharton's jelly-derived mesenchymal stem cells can yield cells for five consecutive times, optimizing primary cell production and reducing costs.

This study found that an enzymatic digestion method for isolating hair follicle stem cells from scalp specimens yielded 5.3 times more epithelial cells than explant cultures, while supporting comparable cell functionality, offering a promising technique for tissue engineering and regenerative medicine.

This study characterized human Wharton's Jelly Mesenchymal Stem Cells (hWJ-MSCs) isolated from umbilical cords using explant and enzymatic methods, finding both methods yielded high-purity cells capable of differentiating into adipocyte, chondrocyte, and osteocyte lineages, showing promise for regenerative medicine applications.

This study found that using trypsin digestion to extract keratinocytes from the hair follicle bulge results in a higher yield and faster growth of stem keratinocytes compared to the explant method.

This study found that engineered reconstituted skin can form morphogenetic units that promote tissue patterning and hair regeneration, with certain signaling pathways restoring this ability in adult and fetal cells.

This study presents an improved protocol for isolating and culturing whole neonatal cochlear explants, enabling detailed analysis of hair cells and spiral ganglion neuron cells while simplifying culture steps without sacrificing explant quality, and was successfully tested on mice and rat cochleas.

This study found that treating human skin explants with TPA increased the number of certain melanocyte phenotypes in the interfollicular epidermis, suggesting that this ex vivo model can effectively replicate human skin's pharmacologic responses for studying potential treatments.

This study reveals that β-catenin and retinoic acid are key regulators in the gene networks controlling the fate of skin appendages, such as scales and feathers.

In this study, epidermal growth factor (EGF) was shown to increase the length of rat organ of Corti segments containing supernumerary hair cells, with the effect peaking at birth and independent of cell division.

This study found that biodegradable PLA particles released fluorochromes in a time-dependent manner on human skin, with BP-PLA particles releasing rapidly and DiAsp-PLA particles providing sustained release and accumulation in hair follicles.

This study concluded that combining cyanoacrylate skin surface stripping with particle-based antigen delivery effectively targets HIV-1 p24 protein to skin cells, supporting its potential for needle-free transcutaneous vaccination.

TRIV-509 quickly improves skin barrier and cell health in atopic dermatitis.

This study suggests that adding androgens to menopausal hormone therapy may reduce breast cancer risk by counteracting estrogen-driven proliferation in postmenopausal breast tissue.

This study found that a skincare product effectively prevented and reduced pollen allergen accumulation in hair follicle models by forming a protective film and exhibiting strong cleansing properties, suggesting its potential to protect skin from environmental elements that can lead to irritation and allergic reactions.

This case report highlights a potential link between silicone breast implants and autoimmune/inflammatory syndrome induced by adjuvants, suggesting explantation may help improve symptoms.

This study found that metformin did not prevent gentamicin-induced hearing loss and even worsened auditory threshold shifts and caused adverse effects at higher doses in guinea pigs.

This study validated the HS 3D-SeboSkin model as a reliable tool for preclinical research, effectively preserving the structure and biomarker expression of lesional and perilesional HS skin ex vivo.

This study found that Ecklonia cava extract increased skin hydration and decreased redness, suggesting potential benefits for protecting and repairing scalp skin from pollutant-induced damage.

This study introduced a reproducible human model using 3D-SeboSkin technology to study hidradenitis suppurativa, allowing better maintenance of skin integrity and replication of biomarker expression patterns compared to traditional skin cultures, suggesting its value for further research.

This study found that gap junctional communication influences feather patterning by modulating Turing-type activator-inhibitor systems in chicken skin, suggesting its role in propagating inhibitory signals crucial for pattern formation.

This study reports a novel LC/MS method that separates and analyzes all known ceramide subclasses in human stratum corneum, identifying a new subclass, CER [EOdS], with minimal sample preparation.

This study found that Eda and activin A regulate Foxi3 expression, which may contribute to the development of hypohidrotic ectodermal dysplasia by affecting Foxi3 activity in ectodermal appendages like hair and teeth.

This study observed that 67 kDa keratin was expressed homogeneously only in epidermis derived from hair follicle explants, differing from other culture methods where expression was delayed and patchy.

This review examines human-relevant in vitro models for studying pigmentation disorders, identifying both challenges and advancements in replicating human pigmentation processes and disease-specific pathology in vitro.

This study observed that follistatin and activin interactions significantly influence hair follicle development in mice, suggesting potential regenerative treatments for alopecia.

This study reports that the tetrapeptide AcSDKP significantly promotes skin and hair health in vitro and ex vivo, suggesting it could be used cosmetically to counteract skin aging and hair loss.