50 citations
,
September 2012 in “Developmental Biology” This study found that over-expressing Spry4 and Fgf10 modulates feather stem cells to alter feather morphologies in distinct ways, affecting barb branch formation and tissue structure.
49 citations
,
March 2019 in “Journal of Investigative Dermatology” This review discusses dermal white adipose tissue's roles in skin immunity, highlighting its antimicrobial function and interactions with other immune cells, but reports no new clinical results.
45 citations
,
October 2008 in “Cytokine & Growth Factor Reviews” This review discusses the role of activin signaling in hair follicle formation, hair growth cycling, and skin healing, but presents no new clinical findings.
44 citations
,
May 2008 in “Plant journal” This study found that D'orenone blocks root hair growth by increasing PIN2 protein abundance, leading to reduced auxin concentration, but external auxin can reverse these effects.
42 citations
,
October 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers identified two distinct homozygous mutations in the KRT85 gene among consanguineous Pakistani families with pure hair and nail ectodermal dysplasia, highlighting variations in severity and potential impacts on the K85 protein function.
40 citations
,
January 2009 in “Skin Pharmacology and Physiology” This review discusses the potential use of cultured primary fetal cells from a single organ donation to produce therapeutic products, emphasizing the need for process consistency and safety verification, but reports no clinical results.
36 citations
,
March 2023 in “Bioengineering” This review discusses the development and impact of barbed sutures on surgical outcomes across various procedures but reports no new clinical results.
34 citations
,
September 2010 in “Clinical and Experimental Dermatology” This study identified a new heterozygous mutation in the connexin 26 gene (c.263C>T; p.Ala88Val) in a premature neonate with KID syndrome, who later died from complications.
33 citations
,
April 2020 in “Dermatitis” This study found that 9% of tested patients had positive patch test reactions linked to hair care products, with most reactions clinically relevant and commonly involving allergens like p-phenylenediamine.
32 citations
,
September 2017 in “Journal of the American Academy of Dermatology” In this study, researchers reported that oral isotretinoin effectively treated facial papules in frontal fibrosing alopecia, with histopathologic findings suggesting the involvement of elastic fibers and sebaceous glands in papule formation beyond perifollicular inflammation.
27 citations
,
January 2016 in “Indian Dermatology Online Journal” This article discusses the advantages and different techniques of dermoscopy for skin lesion visualization and reviewing no new clinical results; it emphasizes the integration of polarized light and the importance of training.
27 citations
,
October 1998 in “Differentiation” Basonuclin helps identify and track hair follicle development and cycling in mice.
25 citations
,
May 2017 in “Developmental Biology” This review highlights how intravital microscopy has advanced understanding of tissue homeostasis and cancer progression, focusing on how tumor cells exploit physiological processes for growth; it reports no new experimental findings.
22 citations
,
December 2020 in “mSphere” This study identified a fungal sulfotransferase enzyme, FgSULT1, from *Fusarium graminearum*, expanding the sulfotransferase superfamily and offering new biocatalytic methods for producing bioactive sulfates.
22 citations
,
June 2004 in “Journal of The European Academy of Dermatology and Venereology” This case report identifies a novel association between Graham Little–Piccardi–Lassueur syndrome and complete androgen insensitivity syndrome, suggesting the influence of androgens in the alopecias accompanying the former may be limited.
22 citations
,
September 2003 in “Journal of Investigative Dermatology” This study analyzed patients with X-linked dominant chondrodysplasia punctata and identified novel mutations in the emopamil-binding protein gene, highlighting the need for genetic testing alongside biochemical analysis for accurate diagnosis.
20 citations
,
February 2019 in “Genes” This study identifies a likely pathogenic homozygous missense variant in the AEBP1 gene in a patient with symptoms of classical Ehlers-Danlos syndrome, suggesting new perspectives for EDS classification and research.
19 citations
,
December 2015 in “European Journal of Human Genetics” This study found that a novel rare variant in ITGB6 may cause intellectual disability, alopecia, and dentogingival anomalies in a specific Pakistani family, highlighting a potential role for ITGB6 beyond enamel formation.
19 citations
,
January 2015 in “Development” This study found that misexpression of Hoxc8 in mice led to ectopic mammary development and suggests Hox genes may play crucial roles in the regional specification and initiation of cutaneous accessory organs.
19 citations
,
November 2010 in “PubMed” This review discusses advancements in the genetic understanding of androgenic alopecia and the FDA-approved treatments, including a new laser hair comb, but reports no clinical results.
18 citations
,
January 2015 in “Experimental Dermatology” This study reports new monilethrix cases in Venezuela, the Netherlands, Belgium, and France, expanding the known mutational spectrum of the disorder with novel mutations in KRT81, KRT83, and KRT86 genes.
18 citations
,
October 2013 in “Stem Cell Research & Therapy” This study found that combining polybrene and a ROCK inhibitor can effectively expand human keratinocyte stem/progenitor cells carrying a transgene, aiding their use in regenerative medicine.
18 citations
,
May 2006 in “Journal of Cutaneous Medicine and Surgery” This study reports the first known case of linear lichen planopilaris following Blaschko's lines in a nonfacial region.
17 citations
,
September 2016 in “Stem cells translational medicine” In this study, using stirred-suspension bioreactors to expand dermal stem cells resulted in larger numbers, but had reduced efficiency in forming hair follicle structures compared to static culture conditions.
16 citations
,
May 2015 in “Tissue Engineering Part C-methods” This study found that expanding hair follicle keratinocytes with a fibroblast feeder followed by short-term coculture with dermal papilla cells could restore their ability to form new hair follicles.
15 citations
,
June 2012 in “British Journal of Dermatology” This study identified a novel KRT86 mutation associated with autosomal dominant monilethrix, expanding understanding of its genetic basis beyond known motifs.
13 citations
,
February 2024 in “Cureus” This review discusses the emerging role of platelet-rich plasma in bone healing and reports no new clinical results; it highlights promising outcomes from existing research and calls for further standardization and exploration in this field.
13 citations
,
September 2014 in “Birth defects research” This review discusses human epidermal neural crest stem cells (hEPI-NCSC) as candidates for cell-based therapies and drug discovery but reports no new experimental results.
13 citations
,
September 2011 in “Archives of dermatology” This case report describes a 3-year-old male with X-linked ichthyosis and associated neurologic abnormalities, identifying an unusual cortical development malformation and suggesting that abnormal hair banding may assist diagnosis.
13 citations
,
November 2005 in “Veterinary Dermatology” This study reports that a German Shepherd developed generalized calcinosis cutis following a presumed bacterial infection, representing the first known case linked to such an infection in adult dogs.