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The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.

The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.

The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.

Hormone imbalances can cause specific skin changes, which may help in early detection of endocrine disorders.

Testosterone therapy is generally safe for transmen, improves sexual function, and has manageable health risks with proper monitoring.

No definitive link between finasteride and male breast cancer, but further research is needed.

The document reviews various hair and nail disorders, their causes, and treatments, emphasizing the need for proper diagnosis and the link between nail changes and systemic diseases.

Early diagnosis and treatment with Leuprolide are key for children with precocious puberty.

Obesity leads to physical, metabolic, reproductive issues, higher healthcare costs, and mental health problems.

PCOS causes infertility mainly due to hormonal imbalances, insulin resistance, and chronic inflammation.

Polycystic ovary syndrome increases the risk of diabetes, heart disease, and endometrial cancer, and requires early treatment to manage these risks.

Testosterone can help premenopausal and postmenopausal women with low sexual desire, but its long-term safety is unclear and it's not widely approved for this use.

Polycystic ovary syndrome and iron overload share similar symptoms and can be potentially treated with blood removal, diet changes, and probiotics.

PCOS management includes lifestyle changes and medications, with ongoing research into repurposed drugs for better treatment options.

There are various effective hormone treatments for puberty induction in boys and girls with hypogonadism, and starting treatment early is important.

PCOS is a complex disorder managed by treating symptoms and requires a team of specialists.

The document concludes that managing skin conditions during pregnancy is important and requires specialized care.

Skin aging reflects overall body aging and can indicate internal health conditions.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

PCOS starts in adolescence with hormonal issues, leading to adult health problems, and early treatment is crucial.

The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.

Products should be called 'sperm-safe' only after thorough, well-designed tests.

Adult skin quickly reacts to short-term environmental and internal stress, leading to various skin issues and the need for protective measures.

Fadrozole and finasteride change gene expression related to sex hormones and thyroid hormones in frog larvae development.

Acne can be managed with various treatments and requires psychological support due to its emotional impact.

Treatment during development affects hormone balance and sexual behavior in male rats.

Cocaine impairs male sexual behavior and alters testosterone metabolism in the brain.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.