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Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

Hair problems can be caused by genetics or the environment, and treatment should focus on the cause and reducing hair damage.

Proper control of β-catenin activity is crucial for development and preventing diseases like cancer.

Wnt proteins from certain skin cells are crucial for normal hair growth and renewal.

Temporary ROS production in cultured human hair follicles promotes growth and stem cell activation.

The document concludes that treating androgen excess needs patience, managing expectations is important, and many drugs used are not officially approved, suggesting cosmetic options for mild cases.

Good feather growth in poultry needs the right balance of proteins, amino acids, minerals, and vitamins.

Basal cell carcinomas may differentiate similarly to hair follicles and could be influenced by hair cycle-related treatments.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

A protein from certain immune cells is key for new hair growth after skin injury in mice.

Too much Smad7 changes skin and hair development by breaking down a protein called β-catenin, leading to more oil glands and fewer hair follicles.

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

Hair, teeth, and mammary glands develop similarly at first but use different genes later.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

High doses of cyproterone acetate are linked to an increased risk of developing meningioma.

Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.