32 citations
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November 2020 in “Nanomaterials” This study found that excipients significantly influence the effectiveness of curcumin nanocrystals in dermal applications, enhancing or hindering hair follicle targeting and passive diffusion based on their selection.
In this study, researchers reported that hardshell capsules using the DiluCap® line of excipients demonstrated varying dissolution profiles under gastrointestinal-simulating conditions, with minoxidil and finasteride showing rapid release and melatonin and naltrexone displaying controlled release, indicating their suitability for different applications in compounding pharmacies.
May 2026 in “Pharmacy Reports” This systematic review found that while green solvent- and natural excipient-based semisolid formulations often show promising efficacy and safety compared to conventional options, the evidence does not currently establish superior stability, highlighting a need for further research on long-term formulation quality.
2 citations
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January 2012 in “Hair therapy & transplantation” This study observed that DDAIP-HCl enhanced the permeation of minoxidil through human cadaver skin, suggesting potential for improved treatment efficacy in male pattern hair loss.
October 2020 in “Open Repository of the University of Porto (University of Porto)” May 2025 in “Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi” In this study, researchers found that minoxidil is compatible with excipients such as Beta-cyclodextrin and cellulose, while it is incompatible with Eudragit S 100 and mannitol, indicating potential formulation challenges in pharmaceutical applications.
January 2018 in “Journal of analytical, bioanalytical and separation techniques” May 2020 in “riUfes (Universidade Federal do Espírito Santo)” This study found that finasteride is stable under various stress conditions except for basic hydrolysis at extreme pH levels and identified compatible and incompatible excipients in pharmaceutical formulations, suggesting formulation changes for increased safety.
1 citations
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January 2016 in “Hair transplant forum international” This article compiles internet forum posts discussing differences between brand-name and generic finasteride pills, but it presents no new clinical findings.
22 citations
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April 2018 in “Pharmaceutics” This special issue reviews current challenges and innovative solutions for enhancing the penetration of topical formulations for human skin, reporting no new results.
3 citations
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January 2022 in “Pharmaceutics” This review examines new formulations for delivering 5-α-reductase inhibitors to improve targeted drug delivery in androgenetic alopecia, but reports no new clinical results.
2 citations
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May 2021 in “Research Square (Research Square)” This study found that ketoconazole-loaded solid lipid nanoparticles significantly improved skin permeation and retention compared to a drug suspension and marketed product, demonstrating enhanced delivery into deeper skin layers.
This study found that Finasteride Dispersible Tablets, prepared with an optimized prescription, disintegrate quickly, disperse well, and have a high dissolution speed, suitable for industrial production.
August 2017 in “Journal of Pharmacy Practice and Research” This study details a method for assessing the risk of modifications to pharmaceutical frame formulations by assigning a risk priority number using Failure Modes Effects Analysis, which estimates the severity and probability of changes impacting the formulation.
March 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This review discusses the formulation and evaluation of herbal hair serums, highlighting the use of natural ingredients like fenugreek, hibiscus, and kalonji, which are claimed to improve hair strength and scalp health.
March 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This review details the formulation, ingredients, and evaluation of herbal hair serum, noting its potential to improve hair texture and scalp health through the use of natural phytoconstituents.
December 2023 in “International Journal of Advanced Research in Science, Communication and Technology” This study developed and validated a precise and rapid HPLC method to simultaneously determine Minoxidil and Finasteride in pharmaceuticals, demonstrating successful application for routine quality control without interference from excipients.
September 2016 in “Aktualʹnì pitannâ farmacevtičnoï ì medičnoï nauki ta praktiki” In this study, researchers at Zaporozhye State Medical University developed a 2% minoxidil cream-mask and found it thermally stable during manufacturing, with no chemical interactions between active and base components, signaling potential for effective hair growth stimulation treatments.
This study found that a 2% minoxidil cream for androgenous alopecia maintained optimal rheological properties for consistent application and long-term stability.
1 citations
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February 2022 in “Scholars international journal of traditional and complementary medicine” In this study, researchers formulated a hair gel using guar gum and jatamansi extract, evaluating its physical properties and noting that jatamansi may promote hair growth, with the gel meeting various parameters such as pH, viscosity, and spreadability.
July 2025 in “Indian Dermatology Online Journal” In this case report, researchers documented a rare instance of trans-epidermal elimination of insulin formulation in a 45-year-old woman with diabetes, suggesting that insulin or its excipients may have caused a granulomatous reaction leading to skin lesions at injection sites and impaired diabetes control.
May 2026 in “Carbohydrate Polymer Technologies and Applications” This study found that the carbohydrate-based excipient β-cyclodextrin forms a stable inclusion complex with the active ingredient of Minoxicapil®, potentially enhancing its formulation for hair-loss treatment, and in vitro assays suggest improved proliferation of DPC cells, supporting its use in topical treatments.
14 citations
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August 2018 in “Journal of Pharmaceutical and Biomedical Analysis” This study found that finasteride maintained chemical and physical stability in various excipient mixtures, which may guide the development of stable topical delivery systems.
19 citations
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February 2021 in “International Journal of Pharmacognosy and Chemistry” This review discusses the pharmacological and pharmaceutical applications of Hibiscus rosa sinensis but does not report new findings, emphasizing its use as an excipient due to its medicinal properties.
3 citations
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July 2022 in “BMC chemistry” This study introduced and validated new spectrophotometric methods to simultaneously determine finasteride and tadalafil in Entadfi™ capsules with high sensitivity and without interference from excipients.
1 citations
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January 2012 in “Analytical chemistry, an Indian journal” This study successfully developed and validated a sensitive and precise liquid chromatography method for simultaneously estimating tamsulosine hydrochloride and finasteride in tablets, showing high accuracy and minimal interference from excipients.
January 2026 in “International Journal of Applied Pharmaceutics” This study developed a novel LC-ESI-MS/MS method to quantify Minoxidil in pharmaceutical forms, finding it precise, accurate, and robust. It withstands excipient and degradant interference, although Minoxidil degrades under some stress conditions but remains stable thermally.
In this case study, a patient developed a rash consistent with acute generalized exanthematous pustulosis after increasing the dose of semaglutide, suggesting that the reaction was likely due to the excipient propylene glycol, highlighting the importance of ingredient analysis and multidisciplinary collaboration for patient safety.
June 2025 in “Indian Journal of Heterocyclic Chemistry” In this study, researchers developed a precise and rapid method for simultaneously analyzing minoxidil and finasteride in local therapeutic formulations, ensuring that the excipients did not interfere, making it suitable for routine quality control.
5 citations
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January 2011 in “Der Pharmacia Lettre” This study validated a precise and sensitive reverse phase high performance liquid chromatographic method for determining Finasteride and Tamsulosin concentrations in bulk and tablet forms, with satisfactory accuracy and reproducibility.