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    Glossary Ex Vivo Culture

    growing cells or tissues outside their original biological context

    Ex Vivo Culture refers to the process of growing or maintaining cells, tissues, or organs outside of their original biological context, typically in a controlled laboratory environment. This technique allows researchers to study biological processes in a more natural state than in vitro (in a petri dish) while still being able to manipulate and observe the sample closely. For example, hair follicles can be cultured ex vivo to study hair growth and alopecia treatments.

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    1. A simple method using ex vivo culture of hair follicle tissue to investigate intrinsic circadian characteristics in humans Scientific reports · 2017 · 12 citations
    2. Human hair growth ex vivo is correlated with in vivo hair growth: selective categorization of hair follicles for more reliable hair follicle organ culture Archives of Dermatological Research · 2005 · 27 citations
    3. Ex Vivo Organ Culture of Human Hair Follicles: A Model Epithelial–Neuroectodermal–Mesenchymal Interaction System Methods in molecular biology · 2010 · 13 citations
    4. Prostaglandin F2α stimulates the growth of human intermediate hair follicles in ex vivo organ culture with potential clinical relevance Frontiers in Physiology · 2025
    5. Identification of human hair follicle antigens targeted in the presumptive autoimmune hair follicle disorder alopecia areata and their potential functional relevance in vitro : methods development for isolation and identification of alopecia areata-relevant human hair follicle antigens using a proteomics approach and their functional assessment using an ex vivo hair follicle organ culture model Bradford Scholars (University of Bradford) · 2008
    6. Ex-vivo Hair Growth Promotion Efficacy of Biofield Energy Treated Williams Medium E using Vibrissae Hair Follicle Organ Culture Zenodo (CERN European Organization for Nuclear Research) · 2018
    7. 581 Spontaneous, Intrinsic Aging in Organ-Cultured Human Skin as Novel Ex Vivo Assay to Test Candidate Anti-Aging Actives Journal of Investigative Dermatology · 2022
    8. Intrinsic activation of cell growth and differentiation in ex vivo cultured human hair follicles by a transient endogenous production of ROS Scientific reports · 2019 · 9 citations
    9. 773 Generation of human hair follicle organoids in vitro and ex vivo by co-culture of primary human hair matrix keratinocytes and dermal papilla fibroblasts Journal of Investigative Dermatology · 2020
    10. 613 Assessment of the induction and morphogenic potential of human hair matrix cells and dermal papilla fibroblasts ex vivo Journal of Investigative Dermatology · 2019 · 1 citations
    11. Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion Lab on a Chip · 2013 · 208 citations
    12. A umbilical cord blood-derived exosome product simulates hair growth through laminin V and collagen XVII: an ex vivo study Archives of Dermatological Research · 2025
    13. Effect of Orthosiphon stamineus plant extract on in vitro dermal papilla cell proliferation and ex vivo hair growth Deleted Journal · 2017 · 1 citations
    14. Dedifferentiation of committed epithelial cells into stem cells in vivo Nature · 2013 · 551 citations
    15. Modeling aging in a culture dish: towards the development of more sophisticated in vitro models of human skin aging Ageing Research Reviews · 2026
    16. Assessing the efficacy of mesotherapy products: Ultra Exo Booster, and Ultra S Line Plus in hair growth: An ex vivo study Skin Research and Technology · 2024
    17. Macrophage-Stimulating Protein Promotes Hair Growth Ex Vivo and Induces Anagen from Telogen Stage Hair Follicles In Vivo Journal of Investigative Dermatology · 2004 · 25 citations
    18. 52790 Estetrol (E4) prolongs anagen ex vivo: Does E4 have the potential as novel strategy to treat female pattern hair loss? Journal of the American Academy of Dermatology · 2024
    19. 1372 Biological effects of electrical epilation on human hair follicles and perifollicular skin ex vivo 2018
    20. Analysis of Dermal Papilla Cell Interactome Using STRING Database to Profile the ex Vivo Hair Growth Inhibition Effect of a Vinca Alkaloid Drug, Colchicine International Journal of Molecular Sciences · 2015 · 23 citations
    21. The Thyroid Hormone Analogue KB2115 (Eprotirome) Prolongs Human Hair Growth (Anagen) Ex Vivo Journal of Investigative Dermatology · 2016 · 17 citations
    22. Topically Applied Nicotinamide Inhibits Human Hair Follicle Growth Ex Vivo 2017 · 13 citations
    23. Resident T cell activation leads to human hair follicle immune privilege loss ex vivo, which is prevented by the DHODH inhibitor farudodstat: relevance for alopecia areata Frontiers in Medicine · 2026
    24. ISID1403 - Melatonin protects K15+ human hair follicle stem cells against paclitaxel-induced damage ex vivo 2023
    25. Engineered Nanovesicles from Fibroblasts Modulate Dermal Papillae Cells In Vitro and Promote Human Hair Follicle Growth Ex Vivo Cells · 2022 · 4 citations
    26. Bioinspired engineering of Polygonum multiflorum root nanovesicles regulates dermal papilla cells in vitro and stimulates human hair follicle growth ex vivo Frontiers in Physiology · 2026
    27. In vitro models to study hair follicle generation Elsevier eBooks · 2017 · 5 citations
    28. Glycogen Phosphorylase Inhibitor Promotes Hair Growth via Protecting from Oxidative-Stress and Regulating Glycogen Breakdown in Human Hair follicles Biomolecules & Therapeutics · 2024
    29. Non-thermal atmospheric pressure plasma activates Wnt/β-catenin signaling in dermal papilla cells Scientific Reports · 2021 · 24 citations
    30. Hair Growth Promoting Effect of Urticadioica L Central Asian journal of medical sciences (Print) · 2018