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This study describes a case of a 35-year-old woman who developed symptoms of hyperandrogenism and disrupted steroidogenesis due to chronic use of electronic cigarettes containing compounds similar to etomidate, despite no genetic mutation indicating 11β-hydroxylase deficiency.

This study found that metyrapone and etomidate provide dose-dependent anticonvulsant effects against seizures, with delayed effectiveness linked to increased neurosteroid levels.

In this case report, a rare association between Cushing's syndrome caused by ectopic ACTH from cervical cancer is documented, highlighting the diagnostic challenges, treatment complexity, and high morbidity and mortality, with the patient succumbing to septic shock post-surgery.

This case report highlighted a rare instance of Cushing's syndrome caused by ectopic ACTH from cervical cancer, demonstrating diagnostic challenges, treatment complexity, and high risks of morbidity and mortality, with less than 10 cases documented overall.

This case report describes a patient with ectopic Cushing's syndrome who experienced fatal complications from COVID-19, highlighting the challenges in managing such patients due to immune response alterations from endogenous hypercortisolemia.

This review focuses on neuroactive steroids' influence on GABA-ergic signaling and discusses challenges in developing them for various therapeutic uses, citing recent excitement from FDA approval of allopregnanolone for postpartum depression but reporting no new results.

This review discusses the role of δ-subunit-containing GABA A receptors and neurosteroids in temporal lobe epilepsy, highlighting their plasticity and potential pharmacological implications, without reporting new clinical results.

This review discusses how neurosteroids acting on GABAA receptors may influence behavior and explores the potential for developing selective modulators for treating psychiatric disorders, but reports no new clinical results.

A young man with an eating disorder had a life-threatening adrenal crisis due to an autoimmune condition, highlighting the need for better education on managing hormone treatments.

This review discusses the regulation of hair growth, causes of excessive androgen secretion, and current safe solutions for hyperandrogenism manifestations in women but reports no new clinical results.

This review summarizes the structural and chemical characteristics of current and novel antiandrogenic drugs but reports no new clinical findings.

In this study, the ChatGPT-5 model accurately answered 76.47% of questions on the Polish endocrinology specialty exam, surpassing the 60% passing threshold, yet its role in clinical decision-making remains uncertain, highlighting the need for further research.

In this case study, a 12-year-old boy with Cushing's Disease experienced a complex diagnostic journey; ultimately, a left-side ACTH-secreting microadenoma was identified and treated with gamma knife therapy, normalizing hypercortisolism but resulting in growth hormone deficiency.

Pharmacists play a crucial role in customizing treatments and ensuring medication safety.

This article reviews existing knowledge on postmenopausal hyperandrogenism and highlights diagnostic challenges, reporting no new clinical results.

This review discusses the diagnostic challenges of androgen and estrogen-secreting adrenal tumors and highlights that the presence of metastases is the most reliable indicator of malignancy; it reports no new clinical findings.

In this study, the synthesis of C-4 and C-6 bridged haptens of 11 alpha-hydroxyprogesterone revealed an unexpected formation of a C-4 substituted product using a 6-bromo derivative, contrary to prior reports.

Among families with pediatric brain disease, this study identified over 200 novel genetic causes, revealing potential treatment points using drug repurposing or nutritional supplementation.

This article reviews the types and characteristics of adrenal cortex tumors, including their hormone secretion and detection as incidental findings, but presents no new research results.

This study found that midazolam, unlike clonazepam, increased neurosteroid levels and affected synaptic inhibition and plasticity in rat hippocampal neurons, suggesting unique actions via dual receptor activation.

This study found that the antiseizure activity of midazolam primarily occurs through synaptic GABA-A receptors, with no significant involvement of endogenous neurosteroids or extrasynaptic receptors.

This study reported that the combined use of dexmedetomidine and ketamine, along with peripheral nerve blocks, provided adequate sedation and analgesia with maintained hemodynamic stability in patients undergoing minor surgical procedures like split skin grafting.

This study found that midazolam improved PTSD-associated behavioral deficits in rats through its action on the TSPO, CBR, and neurosteroidogenesis pathways.

This study found that enhanced neurosteroid synthesis likely mediated by the translocator protein contributed to the anticonvulsant action of midazolam in mice.

This study found that Dex-loaded hyaluronic acid hydrogel microneedles significantly reduced pain in an acute inflammatory visceral pain model without sedation, suggesting a promising and patient-friendly alternative to intravenous delivery.

This study concluded that the anesthesia protocol using fentanyl, propofol, cisatracuria besylate, tranexamic acid, atropine, and metoclopramide resulted in the least pain during septoplasty.

In this animal study, the methanolic extract of Crataeva nurvala leaves was found to possess sedative and anxiolytic properties, potentially linked to GABAergic activity and certain neuroactive compounds.

This study found that inhaling toluene reduces core temperature in mice, with GABA receptors and neurosteroids involved at 4000 ppm, but different mechanisms contributing at 6000 ppm.

This study found that methanol extract of Mimosa pudica showed dose-dependent sedative effects in mice, suggesting its potential for developing new sedative and anti-anxiety medications.

This study found that estazolam improved PTSD-like behavior deficits in an animal model, which was linked to increased allopregnanolone levels in specific brain regions.