May 2026 in “Bioscientia Medicina Journal of Biomedicine and Translational Research” In this study, topical red onion ethanol extract significantly restored cutaneous antioxidant and pro-angiogenic markers in UV-B-exposed rats, enhancing SOD and VEGF levels dose-dependently, but did not influence hair length, suggesting potential as an adjunct for hair photoaging.
April 2026 in “The Plant Journal” This study demonstrated that MYB83 plays a crucial negative role in ethylene-mediated root hair growth in Arabidopsis by directly inhibiting EIN3, and that manipulating the MYB83-EIN3 interaction is key to root hair development and plant tolerance to nutrient stress conditions.
January 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This paper discusses ethosomal drug delivery systems, highlighting their improved ability to enhance skin penetration and increase therapeutic effectiveness in treatments like acyclovir for herpes labialis and minoxidil for androgenic alopecia compared to standard formulations.
January 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study reports that ethosomal formulations, such as ethosomal acyclovir and minoxidil, improved therapeutic effectiveness by enhancing skin permeation, leading to faster healing of herpes labialis lesions and increased skin absorption compared to standard formulations.
December 2025 in “eTheses of Maulana Malik Ibrahim State Islamic University (Maulana Malik Ibrahim State Islamic University)” In this laboratory study, the researchers reported that an ethnomedicinal hair growth formula from East Nusa Tenggara, incorporating Kemiri, Kembang sepatu, Beringin, Mangkokan, and Waru, demonstrated significant antioxidant activity and effectively stimulated hair growth, suggesting potential development as a natural cosmeceutical.
December 2025 in “eTheses of Maulana Malik Ibrahim State Islamic University (Maulana Malik Ibrahim State Islamic University)” This study found that the highest antioxidant-activity formulation of the RENTT herbal combination effectively stimulated hair growth in mice and may serve as a natural therapy for chemotherapy-induced alopecia.
December 2025 in “eTheses of Maulana Malik Ibrahim State Islamic University (Maulana Malik Ibrahim State Islamic University)” This study found that an optimal combination of ethnomedicinal extracts from East Nusa Tenggara, Indonesia, significantly increased hair length in mice, suggesting potential as a natural agent for hair growth through antioxidant mechanisms.
December 2025 in “eTheses of Maulana Malik Ibrahim State Islamic University (Maulana Malik Ibrahim State Islamic University)” This study concluded that the combination 3 of the Nusa Tenggara Timur Ethnomedicinal Formula shows strong antioxidant activity and significantly increases hair follicle thickness in a chemotherapy-induced alopecia model in mice.
October 2025 in “Lithuanian University of Health Sciences” This study documented 81 plant species used traditionally in Lithuania's Šiauliai District for treating skin diseases and cosmetic purposes, highlighting the continued relevance of plant-based remedies and the market demand for natural products.
September 2025 in “International Journal of Pharmaceutics and Drug Analysis” This study discusses ethosomes, which are lipid-based vesicular carriers that improve drug penetration into the skin due to their high ethanol content, highlighting their benefits in drug delivery despite stability issues like phospholipid oxidation and vesicle fusion during storage.
August 2025 in “OBM Integrative and Complementary Medicine” This review consolidates evidence on 93 plant species used in Zimbabwe for treating 21 skin-related conditions, reporting antimicrobial, anti-inflammatory, and antioxidant properties, though safety data remains inconsistent.
May 2025 in “Journal of the European Academy of Dermatology and Venereology” This study reported that etrasimod did not achieve significant improvements in hair regrowth for moderate to severe alopecia areata at 24 weeks, although it showed a dose-dependent trend and was safe and well-tolerated over 52 weeks.
January 2025 in “Bandung Conference Series Pharmacy” This study found that a solid shampoo containing 15% tin leaf extract (Ficus carica L.) and 1% vitamin E exhibited strong antioxidant activity, with a 53.43% inhibition of free radicals in hair and scalp, suggesting potential for reducing hair loss and premature aging.
January 2025 in “NATIONS UNIVERSITY INTERNATIONAL JOURNAL OF MULTI-DISCIPLINARY STUDIES” This study found that only 48% of the medicinal plant uses reported by people in Lithuania's Marijampole region align with European Medicines Agency guidelines, highlighting the need for further evaluation of ethnopharmacological practices.
January 2025 in “Open Science Framework” This abstract outlines the genetic and biological processes of hair growth, highlighting that various hair disorders can have significant medical, aesthetic, and psychological impacts, though specific research findings or results were not reported.
January 2025 in “American Journal of Translational Research” This study reported that the combination of EE-CPA and raloxifene effectively manages PCOS-related infertility, enhancing pregnancy outcomes through improvements in metabolism, sex hormones, ovarian function, and endometrial receptivity, without significantly increasing adverse effects.
December 2024 in “Jurnal Mandala Pharmacon Indonesia” In this study, high-dose oral administration of Ramania leaf ethanol extract in Wistar rats resulted in no significant acute toxicity symptoms, though gastric ulcers and hair loss were observed. The extract is classified as non-toxic under specified guidelines, with an LD50 greater than 5000 mg/kg.
October 2024 in “Clinical and Experimental Dermatology” This study found that combining 17α-estradiol 0.01% with minoxidil 2% offered no statistically significant advantage over minoxidil alone for treating female pattern hair loss and may increase the risk of menstrual irregularities.
October 2024 in “AL-MIKRAJ Jurnal Studi Islam dan Humaniora (E-ISSN 2745-4584)” This study found that a hair tonic made with 30% ethanol extract from papaya fruit peel effectively promoted hair growth in guinea pigs, with results close to those of a positive control, and contains beneficial compounds like alkaloids and flavonoids.
August 2024 in “Journal of Ayurveda and Holistic medicine.” This review study reports that while Bharangi, a traditional Indian medicinal shrub, is used for various conditions like asthma and epilepsy, it has been clinically underexplored and could benefit from scientific validation for broader use.
August 2024 in “Majalah Obat Tradisional” This study found that microemulsions containing ethanol extract of cayenne pepper were effective in enhancing hair growth in rabbits, with the 0.2% concentration achieving the most significant results over a 30-day period, compared to a negative control.
July 2024 in “Natural Product Research” Nk-EE may help treat hair loss by promoting hair growth and preventing hair follicle damage.
June 2024 in “Deleted Journal” This study explored the effects of hair tonics made from a combination of kelor leaf and fragrant pandan leaf ethanol extracts on rat hair growth, finding that these combinations influenced hair growth when compared to single extract formulations over 28 days.
May 2024 in “Jurnal Penelitian Farmasi dan Herbal” In this experimental study using male rabbits, researchers found that a 7.5% concentration of green tea leaf ethanol extract hair tonic was nearly as effective in promoting hair growth as the positive control, minoxidil, over a 21-day period.
January 2024 in “International Journal of Dermatology Research” This randomized clinical trial found that both topical ethinylestradiol 0.01% combined with minoxidil 2% and minoxidil 2% alone were similarly effective in enhancing hair growth for female pattern hair loss, though minoxidil alone was better tolerated with fewer side effects over 24 weeks.
This study observed that women using combined oral contraceptives experienced more nausea, vomiting, and hair loss, while those on Depo-Provera were more likely to gain weight.
November 2023 in “Turkish journal of botany” In this review, researchers documented 439 plant taxa from 89 families in Türkiye used for ethnomedical treatments of skin diseases or as cosmetics, identifying Plantago lanceolata and several other common species, providing a resource for future studies on herbal remedies for dermatological disorders.
November 2023 in “Facial Plastic Surgery” This article examines the ethical concerns and marketing practices of follicular unit excision hair restoration surgery, highlighting misconceptions such as "scarless surgery," without presenting new clinical findings.
September 2023 in “Journal of the American Academy of Dermatology” Hispanic and Black patients are underrepresented in alopecia areata clinical trials.
July 2023 in “International journal of research publications” In this study, topical application of 45% robusta green coffee bean extract in male wistar rats did not significantly enhance hair growth but effectively inhibited the increase of 5α-reductase type 1 levels when exposed to testosterone.