1 citations
,
June 2022 in “Frontiers in Neuroanatomy” This study found that neonatal blocking of androgen and estrogen pathways in rats altered sex-specific expression of estrogen and androgen receptors in adult pituitary and adrenal glands, potentially influencing lifelong neuroendocrine function.
This article discusses the positive effects of estrogens and progestagens on various general diseases, but reports no new clinical results; the mechanisms and treatment approaches are presented.
April 2016 in “The FASEB Journal” This study found that blocking androgen receptors in male rats during the perinatal period led to permanently increased estrogen and ER-a expression in the hypothalamus, affecting sexual preference in adulthood.
67 citations
,
January 2007 in “Climacteric” This article discusses the impact of estrogens on skin aging, highlighting the potential benefits and unresolved effectiveness of alternatives like phytoestrogens and selective estrogen receptor modulators; it reports no new clinical results.
120 citations
,
October 2007 in “Clinical Interventions in Aging” This review discusses the effects of estrogens on skin aging and highlights the potential benefits of estrogen replacement therapy and selective estrogen receptor modulators for improving skin health in postmenopausal women, but reports no new clinical findings.
1 citations
,
January 2004 in “PubMed” In this study, NGF and minoxidil increased the growth of human hair follicles while 17 beta-E2 inhibited it; NGF also neutralized 17 beta-E2's inhibitory effect.
7 citations
,
September 2023 in “Cancer Treatment Reviews” This review highlights the possible impact of side effects from endocrine therapy on quality of life, emphasizing that these can lead to poor adherence and early treatment discontinuation in patients with hormone receptor positive early breast cancer, potentially worsening survival outcomes.
May 2013 in “UTUPub (University of Turku)” This study suggests that adding androgens to menopausal hormone therapy may reduce breast cancer risk by counteracting estrogen-driven proliferation in postmenopausal breast tissue.
11 citations
,
July 1998 in “Journal of Investigative Dermatology” β-estradiol slows hair growth in mice.
30 citations
,
March 2008 in “Wound Repair and Regeneration” This study found that estrogen affected cell behaviors differently in a scratch-wound assay, increasing VEGF secretion in follicular dermal papilla cells but decreasing it in wounded dermal sheath cells.
July 2025 in “Journal of Investigative Dermatology”
12 citations
,
October 2004 in “Experimental Gerontology” This review summarizes how common polymorphisms in androgen and estrogen receptor genes may influence aging-related symptoms and diseases in men, but it reports no new clinical results.
3 citations
,
December 2011 in “Pediatric Dermatology” In this case report, estrogen substitution therapy slightly increased hair volume in a 22-year-old patient with genetic predisposition to hair loss and alopecia caused by past treatment for leukemia, but hair loss returned after stopping the therapy.
2 citations
,
January 1985 in “Theriogenology” Hormonal treatments affect cow fertility and early embryo development.
26 citations
,
February 2009 in “Drug Development Research” This article reviews the potential neuroprotective effects of 17α‐estradiol in neurodegenerative diseases and highlights its possibly lower toxicity compared to more feminizing hormones, but it reports no new clinical findings.
9 citations
,
January 2018 in “American Journal of Men's Health” This study analyzed self-reports from discussion forums to categorize and understand adverse effects experienced by individuals using finasteride, suggesting a need for further investigation into post-finasteride syndrome.
36 citations
,
July 1980 in “Journal of Toxicology and Environmental Health” In this animal study, rats given high doses of ethynylestradiol showed dose-related estrogenic effects, delayed tumor onset in females, and no overall increase in tumor incidence compared to controls.
11 citations
,
January 1980 in “PubMed” This article reviews various side effects and concerns related to oral contraceptives, including potential vascular complications and elevated plasma cortisol levels, but reports no new clinical results.
9 citations
,
February 2022 in “Biomedicines” This study suggests that testosterone therapy in AFAB individuals may modify the methylation of the ESR2 promoter, with changes influenced by factors like total testosterone levels and age.
8 citations
,
April 1990 in “Hormone and Metabolic Research” This study found that a combination of cyproterone acetate and ethinyl estradiol over one year did not affect glucose tolerance but increased total cholesterol, HDL cholesterol, and triglycerides in patients with moderate hyperandrogenism.
3 citations
,
January 1985 in “PubMed” This review discusses the complex dermatological effects of oral contraceptives, including both hormonal benefits and potential toxicities, but reports no new clinical results.
This study found that tamoxifen citrate markedly inhibited castration-induced diffuse hair growth in castrated female mice, while cyproterone showed only slight inhibition in male mice.
44 citations
,
October 2011 in “Gynecological Endocrinology” This review discusses the effects of oestrogen on skin ageing and highlights the need for large-scale clinical trials to evaluate postmenopausal oestrogen use, reporting no new findings.
11 citations
,
July 2001 in “APMIS. Acta pathologica, microbiologica et immunologica Scandinavica./APMIS” This review discusses the role of oestrogens in stimulating linear bone growth and pubertal changes in both boys and girls, highlighting their influence on the growth hormone-insulin-like growth factor axis; it reports no new clinical results.
228 citations
,
February 2003 in “Urology” This article discusses the side effects of androgen deprivation therapy for nonmetastatic prostate cancer, highlighting the need for clinical trials to systematically study these effects.
102 citations
,
July 2020 in “International journal of molecular sciences” This review discusses the effects of hormonal changes on hair follicles, concluding that hormones like androgens and estradiol significantly influence hair growth and cycle, while the roles of other hormones are still being researched.
34 citations
,
May 1987 in “European Journal of Pediatrics” This study concluded that Buserelin can effectively inhibit gonadal activity in children with central precocious puberty over 18 months, potentially improving final height predictions with prolonged treatment.
10 citations
,
January 2017 in “The World Allergy Organization journal” This article collection reviews the significant influence of gender and sexual hormones on allergies and asthma, noting more severe symptoms in females and the role of estrogen.
2 citations
,
March 2005 in “Journal of the American Academy of Dermatology” Equol may help with antiaging and skin health by boosting collagen and blocking certain hormones.
2 citations
,
September 1971 in “Metabolism, clinical and experimental” In this study, patients with testicular feminization syndrome showed limited anabolic responsiveness to dihydrotestosterone, potentially due to reduced affinity of nuclear receptor sites for androgenic steroids rather than defective testosterone conversion.