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Men are more likely to have severe COVID-19 cases and fatalities than women due to factors like lifestyle, aging, and biological differences.

Menopause can lead to skin and hair problems due to hormonal changes, but hormone replacement therapy might help slow these effects.

Hormone treatments in transsexual individuals reduce hair growth and oil production in male-to-females and increase them in female-to-males.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

Most youth with gender dysphoria received hormones, had minor complications, and showed a decrease in suicide attempts after treatment.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.

Amenorrhea is relatively rare and initial testing should check FSH, TSH, and prolactin levels.

Sex hormones, especially androgens, play a key role in causing acne.

Pregnancy causes skin changes like darkening, hair thickening, nail changes, and increased risk of skin growths, most of which usually resolve after birth.

Finasteride reduces hairiness and androgen levels in women with unexplained excessive hair growth.

Some hair loss can be treated, especially in women due to nutrition, but some types remain untreatable.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Red ginseng may improve immunity, fatigue, memory, blood circulation, and menopausal symptoms, and is generally safe to consume.

Fulvestrant is a well-tolerated new treatment for advanced breast cancer that may delay chemotherapy.

Pregnancy often causes skin changes like darkening, stretch marks, and hair growth, which may improve after childbirth.

The review recommends hormone replacement therapy for women with premature ovarian insufficiency to manage symptoms and protect health, with specific approaches for different groups.

Menopause and aging can affect women's quality of life and sexuality, but hormone therapies may help alleviate these issues.

Hair loss in women may have causes other than hormones.

Frontal fibrosing alopecia mainly affects postmenopausal women and may be linked to thyroid hormones.

Current murine models need improvement for better human wound healing research translation.

Testosterone replacement may improve sexual desire and bone health in women with low androgen levels, but more research is needed on its long-term safety.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Testosterone therapy can help improve sexual desire and function in postmenopausal women but may cause side effects and is not FDA-approved for this use.

Gonadal dysgenesis, like Turner's and Klinefelter's syndromes, negatively affects bone health, but hormone treatments can help.

Menopause significantly reduces skin collagen, leading to thinner, less elastic skin, and hormone replacement may help but requires careful consideration.

Sex hormones may affect COVID-19 severity, with men often faring worse, and targeting related pathways could offer treatment options.