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The conclusion is that the best initial treatment for hirsutism is usually oral contraceptives, with the addition of antiandrogens or insulin sensitizers if needed, and topical eflornithine or laser treatments as supplementary options.

Neurosteroids show promise for treating epilepsy and more research is needed.

Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.

Researchers found 63 genes linked to male-pattern baldness, which could help in understanding its biology and developing new treatments.

Scalp cooling can prevent chemotherapy-induced hair loss, and certain treatments can speed up hair regrowth, but more research is needed for better treatments.

Prolactin affects the production of different keratins in human hair, which could lead to new treatments for skin and hair disorders.

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

Insulin resistance contributes to hormone imbalances in many women with polycystic ovary syndrome.

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

Products should be called 'sperm-safe' only after thorough, well-designed tests.

Obese women with PCOS show a male-like pattern in certain fat tissue gene expressions.

High levels of testosterone and 5α-DHT can lead to cell death in cells important for hair growth.

Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.

Androgens play a complex role in skin conditions like acne and hair loss in women, and normal blood levels don't always show true androgen status.

Finasteride helps reduce heart issues and improves heart function.

Multiple treatments work best for hair loss.

Ablative fractional resurfacing could improve how well topical drugs penetrate the skin, but more research is needed to fine-tune the method.

Androgen conjugates might be better indicators of skin sensitivity to hormones in women with excessive hair growth.

Minoxidil helps grow longer, thicker hair in bald scalps of stumptailed macaques, and early treatment is more effective.

Finasteride and minoxidil work best together for hair loss.

Cancer treatments often cause hair disorders, significantly affecting patients' quality of life, and better management methods are needed.

Excessive hair growth in women often has no known cause and is not linked to race or other hormonal symptoms.

Prolactin slows down hair growth in mice.

Parathyroid hormone-related protein helps control hair growth phases in mice.

The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.

Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.

The drug enzalutamide may reduce the ability of the virus causing COVID-19 to enter lung cells.