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Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Dermatologists play a key role in treating skin symptoms of PCOS like dark patches, excess hair, acne, and hair loss.

Cancer treatments often cause hair disorders, significantly affecting patients' quality of life, and better management methods are needed.

Eating healthy, exercising, and taking certain supplements can help manage Polycystic Ovary Syndrome symptoms.

The document concludes with guidance for doctors on diagnosing and treating hirsutism effectively and safely.

Hormone imbalances can cause specific skin changes, which may help in early detection of endocrine disorders.

Excessive hair growth can be assessed by history, exam, and blood tests, and treated with medication like dexamethasone, birth control pills, and spironolactone.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The current system can't fully test all combination treatments, so alternative methods and regulatory flexibility are needed.

DHT's role in hair loss is important, but measuring its level for diagnosis is questionable.

Women with excessive male-pattern hair growth should get a full hormone check-up to find and treat any underlying issues, considering both medical and emotional aspects.

Nanomaterials in biomedicine can improve treatments but may have risks like toxicity, needing more safety research.

Obesity worsens Polycystic Ovary Syndrome symptoms, and weight loss is a key treatment.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

PCOS is a complex disorder managed by treating symptoms and requires a team of specialists.

Polycystic Ovary Syndrome can cause hair loss and skin issues, and early treatment is important for preventing complications.

Acitretin is effective for severe psoriasis and can be used long-term due to no immunosuppression, but must be carefully monitored for side effects and is not for pregnant women.

Hormonal imbalances, often indicating conditions like PCOS, are common in women with hard-to-treat acne, and a treatment approach addressing these imbalances may be needed.

Gemcitabine and paclitaxel are effective and safe as first-line treatment for metastatic breast cancer.

Some drugs can cause skin and hair color changes, often reversible when the drug is stopped.

Anti-cancer treatments can cause reversible hair loss, skin sensitivity, pigmentation changes, nail damage, and skin reactions, with a need for more research on managing these side effects.

Effective hirsutism management requires identifying the cause, combining new and traditional treatments, and setting realistic expectations for patients.

CAH is a genetic disorder affecting cortisol production and causing hormonal imbalances, with treatment and diagnosis varying by form and symptoms.

Tamoxifen caused hair loss in a 52-year-old woman.

Both treatments reduced excessive hair growth in PCOS, but there was no difference in weight, hair score, hormone levels, or insulin resistance.

PCOS is a long-term condition that needs more research for better understanding and treatment.

The document says PCOS is a common hormonal disorder in women, diagnosed by certain criteria, and managed with lifestyle changes and various medications.

Some herbal treatments are effective for skin disorders, but more research and regulation are needed.