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The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.

The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Human skin produces sex hormones like estrogen and testosterone, influenced by ARO and StAR, which may affect skin elasticity and hair growth.

Cancer rates are increasing in developed countries, with estrogen, aging, low vitamin D3, and HPV infection as common causes.

5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.

Best treatment for Frontal Fibrosing Alopecia is 5-alpha-reductase inhibitors and intralesional corticosteroids.

Birth control pills with low-dose estrogen and antiandrogenic progestins can effectively treat acne.

The document explains how male reproductive hormones work and affect the body.

Birth control pills help treat skin and hair growth problems linked to high male hormone levels.

Finasteride treatment changes urine metabolomics and steroid signatures, potentially monitoring effectiveness but may cause sexual side effects.

The letter suggests testosterone replacement therapy might worsen COVID-19 outcomes.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

Androgens can help prevent memory problems caused by apoE4.

Men's sensitivity to male hormones might affect how severe COVID-19 gets for them.

Hair loss in androgenetic alopecia is caused by genetic factors and androgen excess, and can be treated with combined therapies.

Finasteride helps reduce heart issues and improves heart function.

Brain hormones significantly affect hair color and could potentially be used to prevent or reverse grey hair.

Spironolactone reduces the enzyme activity that converts testosterone to DHT, helping treat excessive hair growth in women.

Genetics play a role in acne, but how exactly they contribute is not fully understood.

Hormonal treatments can improve acne, but they come with potential side effects and risks.

For women with moderate to severe unwanted hair growth or acne, birth control pills are the first choice, with other medications like cyproterone, spironolactone, flutamide, or finasteride as alternatives, and permanent hair removal should be done with electrolysis or laser.

Treating hirsutism in women often requires a mix of medications and cosmetic methods for best results.

Liquorice may reduce testosterone and affect male reproductive organs, potentially helping treat conditions like prostate cancer.

SARS-CoV-2, the virus causing COVID-19, can affect all endocrine organs and systems, altering their function and potentially leading to disorders. Factors like diabetes and obesity increase infection risk and severity. Understanding these effects is key for effective treatment.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

The document concludes that treating androgen excess needs patience, managing expectations is important, and many drugs used are not officially approved, suggesting cosmetic options for mild cases.

The document concludes that combination therapy is most effective for treating excessive hair growth in women with idiopathic hirsutism, and more research is needed to understand the condition.

Honokiol might help reduce male skin aging by maintaining testosterone levels.

Hair loss causes differ between men and women due to changes in hormone levels and inflammation-related pathways.