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The document concludes that various medications and treatments can have significant, sometimes adverse, effects on health outcomes.

Exposure to certain sex hormones can increase health risks, while some hormone therapies may offer benefits for specific conditions.

Environmental factors like diet and vitamin levels, especially Vitamin D, can affect autoimmune diseases differently, with lifestyle changes potentially improving outcomes.

Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.

The 2024 guideline updates recommendations for genetic testing, imaging, and sperm retrieval in male infertility.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Testosterone replacement may help postmenopausal women with sexual function and bone density, but suitable treatments are limited.

Hormones like androgens, estrogen, thyroid hormones, and stress hormones can contribute to hair loss, and treatments target these hormonal imbalances.

Men and women experience skin aging differently due to changes in sex hormone levels with age.

Hormones like testosterone and estrogen significantly affect hair growth and structure.

High doses of cyproterone acetate increase the risk of brain tumors in women, but the risk decreases after stopping the medication.

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

Understanding genes and hormones is crucial for managing male puberty and sex development disorders.

Androgens affect hair growth and shedding, with genetic and non-genetic factors influencing baldness.

Genetic differences between young and old Tan sheep explain why their fleece changes from curly to straight as they age.

Melasma's causes include genetics, sun exposure, hormones, and oxidative stress, and understanding these can help create better treatments.

Skin side effects from CDK4/6 inhibitors in breast cancer patients are generally mild and treatable, allowing most patients to continue treatment.

Coloring shampoos for gray hair may cause gene mutation, reproductive issues, and skin damage, needing stricter regulation and expert consultation.

Testosterone replacement can help women with low libido and mood, but they need to have enough estrogen first to avoid side effects.

Cells with active Wnt signaling are less likely to turn into cancer when exposed to a cancer-causing gene.

Exemestane may protect bones by stimulating osteoblast growth through androgen-related pathways.

Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.

Sex hormones, especially androgens, play a key role in causing acne.

TNFα, IFNγ, and Substance P significantly affect prolactin levels in human skin, suggesting new treatments for skin and hair conditions.

Breast cancer treatments work better with AR activation, improving results and reducing side effects.

A 31-year-old woman was diagnosed with Complete Androgen Insensitivity Syndrome much later than usual, leading to a call for earlier detection and treatment guidelines.

Spironolactone is safe for treating female hair loss, but the safety of other drugs is uncertain.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

Low androgen levels might delay prostate cancer but could lead to more aggressive, therapy-resistant cancers.

Retinoic acid affects male and female muscle energy use and function differently.