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Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Clascoterone is a new, effective, and safe acne treatment without systemic side effects.

Androgens and androgen receptors are important for metabolic health, affecting how the body uses glucose and fats through mitochondrial function.

MK-0773 safely increased muscle mass but did not improve muscle strength or function in elderly women with sarcopenia.

Hair loss in balding individuals is linked to changes in specific hair growth-related genes.

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.

Certain genetic variants in the androgen receptor are linked to higher PSA levels, potentially affecting prostate cancer screening outcomes.

Mice with more Flightless I protein grew back their claws better after amputation.

Researchers identified genes in scalp hair follicles that may affect hair traits and hair loss.

Finasteride affects offspring's antioxidant enzymes in epididymis, possibly disrupting sperm maturation.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

New genes found linked to balding, may help develop future treatments.

LEF1 interacts with Vitamin D Receptor, affecting hair follicle regeneration and this could be linked to hair loss conditions.

Fadrozole and Finasteride change frog sex ratios and cause intersex animals with altered gene expressions.

The review found no clear link between vitamin D receptor gene variations and polycystic ovary syndrome.

Researchers found 44 proteins that change during different hair growth stages and may be important for hair follicle function.

Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.

The PLP2 gene affects cashmere fiber quality in goats and is linked to hair growth and loss.

Melatonin can increase cashmere yield by altering gene expression and restarting the growth cycle early.

Obese women with PCOS show a male-like pattern in certain fat tissue gene expressions.

Androgens prevent hair growth by changing Wnt signals in cells.

Troxerutin helps protect skin cells from oxidative stress and may be good for treating hair loss.

Testosterone makes the connections in the uterus lining simpler and lowers certain protein levels, which might lead to infertility.

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

Changing protein kinase levels in pituitary cells affects calcium flow and beta-endorphin release.

Finasteride improves heart function and repairs damage after heart attack in mice.

Certain compounds from Panax ginseng can block proteins that affect hair growth, potentially helping treat hair loss.

Mutations in the androgen receptor gene cause Androgen Insensitivity Syndrome, affecting sexual development.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.