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Healthcare claims databases can help monitor drug safety, but may report adverse events differently than direct surveillance.

Woodhouse-Sakati syndrome can cause writer's cramp and other varied symptoms, highlighting the importance of genetic testing for diagnosis.

Hormonal imbalances are a key cause of missed menstrual periods in women.

Hormonal therapy changes skin and hair in transgender patients, who need better researched dermatologic care.

The document concludes that transsexual individuals often experience improved quality of life after transitioning, despite higher risks of psychiatric issues and mortality.

Kelulut Honey can help regulate sex hormone receptors in rats with Polycystic Ovary Syndrome, similar to common medications.

Dihydrotestosterone makes arteries stiffer in female mice by reducing estrogen receptor expression.

Men and women experience skin aging differently due to changes in sex hormone levels with age.

Some hormone treatments might raise breast cancer risk, while others don't seem to.

Exemestane is effective and safe for treating certain breast cancers, with mild side effects, but needs more research on long-term effects.

Testosterone treatment effectively causes male physical development in transgender male adolescents but may lead to side effects like acne, higher BMI and blood pressure, lower good cholesterol, and decreased bone density.

Hormonal treatments are effective for severe or persistent acne and should be used with other acne therapies, considering potential side effects.

Sex hormones may affect COVID-19 severity, with men often faring worse, and targeting related pathways could offer treatment options.

Hormones significantly affect women's sexual function, and more research is needed to improve treatments for sexual dysfunction with minimal side effects.

Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.

The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.

Steroid hormones can help treat aging issues and improve health in elderly people.

A postmenopausal woman's hirsutism and high testosterone levels improved after surgery for an ovarian tumor not seen on ultrasound.

The document concludes that breast pain should be managed with personalized treatment, starting with non-drug methods and progressing to medication if necessary, while considering side effects and patient needs.

Skin symptoms can indicate endocrine disorders and have various treatments.

Older men with low levels of a testosterone byproduct had a higher chance of developing an irregular heartbeat.

Uterine transplants for transgender women are feasible but need more research.

Women have unique stroke risks due to hormones, contraceptives, pregnancy, and menopause.

Some women with acne have higher levels of free testosterone, which might suggest using hormonal treatments for acne.

Menopause affects hair and skin; more research needed for treatment.

The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

The document advises health care providers on how to support transgender and gender-diverse youth with appropriate care and referrals.

The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.

Oral estradiol works for many transgender women but needs personalized dosing and monitoring.

Testosterone in older women can increase bone density, muscle mass, fat mass, improve memory, and boost libido, but may cause nipple color changes.