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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Finasteride effectively treats BPH, but needs more trials to understand potential.

PrEP for HIV is less effective in transgender women mainly due to low adherence to the treatment.

Androgens can both increase and decrease hair growth in different parts of the body.

Iron deficiency may be related to hair loss, but there's not enough evidence to recommend iron screening or supplements for all hair loss patients.

PGD2 stops hair growth and is higher in bald men with AGA.

Male and female skin differ in many ways, which could lead to gender-specific skin treatments.

Early diagnosis and treatment, using finasteride, minoxidil, or hair transplantation, improves hair loss outcomes.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

Lifestyle changes can improve body composition, excess male hormone levels, and insulin resistance in women with PCOS.

Sebocytes play a key role in controlling androgen levels in human skin.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.

The ZIP7 gene helps control zinc levels in cells by moving zinc from the Golgi apparatus to the cytoplasm.

Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

Finasteride treats enlarged prostate and may help with baldness, but effects on sexual function and male fetuses are unclear.

Men are more likely to have severe COVID-19 cases and fatalities than women due to factors like lifestyle, aging, and biological differences.

Spironolactone is a safe and effective treatment for reducing excessive hair growth in women.

Androgens can help prevent memory problems caused by apoE4.

Some postmenopausal women with frontal fibrosing alopecia stopped losing hair with finasteride treatment, hinting at a possible hormonal cause.

Erectile dysfunction is increasingly common in men under 40, with many physical and psychological causes, and various treatment options available.

Women look young for their age due to larger lips, less sun damage, and genes that prevent gray hair and wrinkles.

Oestrogens are key for bone growth during puberty in both boys and girls.

Lower doses of treatments for hirsutism and acne in PCOS are effective and cause fewer side effects.

High androgen levels in young women with PCOS are linked to higher blood pressure.

Some people with pattern hair loss may also have scalp inflammation and scarring similar to lichen planopilaris.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Tributyltin exposure causes sex changes, sterilization, and decline in the snail Ocinebrina aciculata, risking its extinction.