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      Is Dehydroepiandrosterone a Hormone?

      research Is dehydroepiandrosterone a hormone?

      403 citations , November 2005 in “Journal of Endocrinology”
      This review discusses the role of DHEA in intracrinology, highlighting its impact on breast and prostate cancer treatment and potential as a menopause therapy, but reports no new research findings.
      Transplantation Immunology: Solid Organ and Bone Marrow

      research Transplantation immunology: Solid organ and bone marrow

      139 citations , February 2010 in “ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology”
      This review outlines the advancements in organ and tissue transplantation since the discovery of the human MHC and reports no new clinical results.
      Ancient-Modern Concordance in Ayurvedic Plants: Some Examples

      research Ancient-modern concordance in Ayurvedic plants: some examples.

      139 citations , October 1999 in “Environmental Health Perspectives”
      This article reviews the scientific exploration of Ayurvedic medicinal plants and discusses their modern applications, such as a drug developed from Commiphora wightti for lipid disorders, without reporting new clinical findings.
      Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes

      research Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes

      112 citations , November 2023 in “Nano-Micro Letters”
      This review discusses the developments over the past five years in nanozyme-based theranostics for tumor therapy, including their classification, design, and synergistic strategies. It also outlines the challenges and prospects of using nanozymes to enhance selectivity, biosafety, repeatability, and stability in therapeutic applications.
      Interferon in the Treatment of Cutaneous T-Cell Lymphoma

      research Interferon in the treatment of cutaneous T-cell lymphoma

      107 citations , December 2003 in “Dermatologic Therapy”
      This paper reviews the use of interferons, particularly alfa interferon, in treating cutaneous T-cell lymphoma, noting its substantial efficacy both alone and in combination therapies with predictable, generally well-tolerated side effects.
      Baiting Proteins with C60

      research Baiting Proteins with C60

      106 citations , April 2010 in “ACS Nano”
      This study found that about 80% of known fullerene-binding proteins rank in the top 10% of scorers for C60 docking sites, confirming the accuracy of the predictive model used.
      Male Pattern Alopecia: A Histopathologic and Histochemical Study

      research Male Pattern Alopecia A Histopathologic and Histochemical Study

      94 citations , August 1975 in “Journal of Cutaneous Pathology”
      In this study, the researchers observed that male pattern alopecia is characterized by miniature follicles, enlarged sebaceous glands, and an increased number of mast cells, without significant abnormalities in enzyme activity.
      Physiological Functions of PP2A: Lessons from Genetically Modified Mice

      research Physiologic functions of PP2A: Lessons from genetically modified mice

      87 citations , July 2018 in “Biochimica et Biophysica Acta (BBA) - Molecular Cell Research”
      This review discusses the essential roles and complex regulation of PP2A in various physiological processes and reports no clinical results; the authors highlight the need for further mouse model research to explore PP2A's therapeutic potential.
      Molecular Regulation of Melanocyte Senescence

      research Molecular Regulation of Melanocyte Senescence

      85 citations , July 2002 in “Pigment Cell Research”
      This review examines cell senescence pathways in melanocytes, highlighting the involvement of telomere attrition, the p16/RB pathway, and cAMP signaling in the context of melanoma development, but reports no new findings.
      Intracrinology and the Skin

      research Intracrinology and The Skin

      82 citations , January 2000 in “Hormone Research in Paediatrics”
      This study describes the enzymatic processes through which DHEA is converted to active sex steroids in human skin, highlighting an androgenic effect on sebaceous glands and estrogenic effects in the vagina.
      Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis

      research Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis

      78 citations , June 2021 in “Dermatology and Therapy”
      This study highlights the evolving understanding of acne's pathophysiology and suggests that targeting pro-inflammatory cytokines such as IL-1β, IL-17, IL-23, and TNFα with biological antibodies may offer new treatment strategies for severe acne and its scars.
      Absorption Sites of Orally Administered Drugs in the Small Intestine

      research Absorption sites of orally administered drugs in the small intestine

      55 citations , September 2017 in “Expert Opinion on Drug Discovery”
      This review examines the main absorption sites and influencing factors for orally administered drugs, highlighting variables such as solubility and gastrointestinal conditions that affect drug absorption in the small intestine and the development of effective drug delivery systems.
      Nano-PROTACs: State of the Art and Perspectives

      research Nano-PROTACs: state of the art and perspectives

      51 citations , January 2024 in “Nanoscale”
      This review highlights recent advancements in using nanotechnology to improve the function and delivery of PROTAC drugs, despite existing challenges like low solubility and poor permeability, aiming to enhance their potential in disease treatment.
      The Pharmacology of Regenerative Medicine

      research The Pharmacology of Regenerative Medicine

      47 citations , July 2013 in “Pharmacological Reviews”
      This review discusses the role of pharmacological sciences in advancing regenerative medicine technologies but reports no new experimental findings; the authors advocate for increased pharmacologist involvement to drive innovations.
      Diet in Dermatology: Revisited

      research Diet in dermatology: Revisited

      40 citations , January 2010 in “Indian Journal of Dermatology, Venereology and Leprology”
      This article reviews the role of diet in various skin disorders and suggests that dietary changes may aid in managing certain conditions, though it reports no new clinical findings.
      Novel Cosmeceuticals from Plants: An Industry-Guided Review

      research Novel cosmeceuticals from plants—An industry guided review

      39 citations , June 2017 in “Journal of Applied Research on Medicinal and Aromatic Plants”
      This review examines around 68 plant sources from six major plant families, assessing their scientific rationale and use by the cosmeceutical industry for applications like anti-ageing and sun protection.
      Oxygen, Metabolism, and Regeneration: Lessons from Mice

      research Oxygen, Metabolism, and Regeneration: Lessons from Mice

      35 citations , October 2017 in “Trends in Molecular Medicine”
      This research suggests that targeting the HIF-1α pathway via PHD inhibitors may enable regeneration similar to amphibians in mammals, potentially fast-tracking regenerative therapies from mice to humans.
      The Effect of 5-Reductase Inhibitors on Erectile Function

      research The Effect of 5 -Reductase Inhibitors on Erectile Function

      31 citations , September 2008 in “International Journal of Andrology”
      This review examined studies on erectile dysfunction and 5 alpha-reductase inhibitors, concluding that these drugs do not significantly cause erectile dysfunction and emphasizing testosterone's importance over dihydrotestosterone in erectile function.
      Candidate Genes of SARS-CoV-2 Gender Susceptibility

      research Candidate genes of SARS-CoV-2 gender susceptibility

      27 citations , November 2021 in “Scientific Reports”
      This study used bioinformatics to explore molecular differences in testicular and ovarian responses to SARS-CoV-2, identifying genes that could be associated with sex differences in infection outcomes.
      Hormone Therapy in Acne

      research Hormone therapy in acne

      24 citations , January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”
      This review examines hormonal influences on acne development and available hormonal therapies but reports no new clinical results.