April 2023 in “Journal of Investigative Dermatology” This study provides an updated systematic review and meta-analysis showing that alopecia areata is associated with significantly higher odds of several autoimmune and metabolic comorbidities compared to healthy controls.
10 citations
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July 2008 in “Journal of Cutaneous Pathology” This study reports that marked, deep dermal mucin deposition in a patient with alopecia areata may indicate underlying systemic lupus erythematosus, as this feature was not prevalent in other alopecia areata cases.
52 citations
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March 2010 in “British Journal of Dermatology” This study demonstrated the expression of type 1 interferon-related proteins in inflammatory lesions of alopecia areata, showing a distinct distribution pattern compared to cicatricial alopecia.
34 citations
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June 2007 in “The Journal of Dermatology” This study observed that non-scarring diffuse hair loss was common in systemic lupus erythematosus patients, but did not find a significant relationship with the SLE Disease Activity Index.
14 citations
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September 2021 in “Journal of Inflammation Research” This study suggests that female patients with alopecia areata, especially those with nail abnormalities and atopic diseases, may have higher rates of coexisting autoimmune diseases.
7 citations
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July 2025 in “International Journal of Dermatology” This meta-analysis found that patients with alopecia areata have significantly higher odds of also having immune-mediated diseases such as atopic dermatitis, autoimmune thyroiditis, inflammatory bowel disease, systemic lupus erythematosus, and vitiligo, suggesting a need for comprehensive screening and interdisciplinary management.
3 citations
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March 2022 in “PubMed” This review discusses the use of platelet-rich plasma in treating various forms of alopecia, including androgenic alopecia and alopecia areata, but provides no new clinical results.
1 citations
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May 2022 in “Frontiers in Psychiatry” In this case study, a 33-year-old female with neuropsychiatric systemic lupus erythematosus experienced hair regrowth with no further loss after receiving a combination of systemic and local treatments.
1 citations
,
January 2021 in “Nihon rinsho hifukaikai zasshi” This article discusses the diagnostic methods for differentiating alopecia areata from similar hair loss conditions and emphasizes the importance of accurate diagnosis, but it reports no new research findings.
1 citations
,
March 2022 in “PubMed” This review discusses the applications of platelet-rich plasma for non-scarring alopecia, including AGA and AA, but reports no new clinical results.
1 citations
,
September 2021 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study suggests that female patients with alopecia areata, especially those with nail abnormalities and atopic diseases, have a higher prevalence of autoimmune disease comorbidities.
May 2022 in “Rossijskij žurnal kožnyh i veneričeskih boleznej” This paper reviews the complexity of nest alopecia's causes and associations, noting chronicity, recurrence, and associations with comorbid conditions, and presents two clinical cases, but reports no new quantitative findings.
December 2020 in “Journal of Face Aesthetics” This study found that trichoscopy, a non-invasive diagnostic method, may effectively differentiate between types of focal alopecia in the parietal area in adult women, indicating specific trichoscopic features for conditions like alopecia areata, discoid lupus erythematosus, and lichen planopilaris.
July 2025 in “Foundation University Journal of Dentistry” In this study, 25% of alopecia areata patients were found to have autoimmune disorders, with hypothyroidism being the most common, highlighting the importance of screening for autoimmune conditions, particularly thyroid disorders, in these patients.
April 2023 in “Journal of Investigative Dermatology” Periodontitis may increase the risk of developing alopecia areata.
January 2021 in “Anais do Congresso Brasileiro de Reumatologia 2020” In this case report, tofacitinib led to significant improvement in arthritis and partial improvement in alopecia for a female patient with systemic lupus erythematosus, with no observed adverse effects.
February 2013 in “Journal of the American Academy of Dermatology” Follicular red dots can appear where alopecia areata and vitiligo overlap.
157 citations
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August 2010 in “Lupus” This review discusses the various common, rare, and unusual skin manifestations of lupus erythematosus and highlights the importance of accurate diagnosis, but it reports no new clinical results.
2 citations
,
January 2006 in “Technical report” This chapter reviews the development of skin-specific outcome instruments for autoimmune diseases like cutaneous lupus erythematosus and dermatomyositis, highlighting a need for a broader community-involved process across other diseases but reports no new results.
40 citations
,
October 2012 in “Journal of the American Academy of Dermatology” This study found that the Cutaneous Lupus Disease Area and Severity Index (CLASI) is correlated with both physician-assessed and patient-reported outcomes in cutaneous lupus erythematosus, particularly highlighting concerns about body image in visible areas.
19 citations
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September 2010 in “Journal of the European Academy of Dermatology and Venereology” This study found that while the CLASI is generally useful for assessing disease activity and damage in cutaneous lupus erythematosus, it may not accurately reflect all subtypes, indicating a need for revision.
September 2022 in “Dermatology and therapy” This review summarizes current evidence on the use of contact immunotherapy, excluding alopecia areata, for various skin diseases, discussing its safety, efficacy, and the underlying mechanisms as reported from studies in the PubMed database.
3 citations
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January 2018 This study reports a case of pustular allergic contact dermatitis following the use of 5% minoxidil solution in a female patient, highlighting an uncommon reaction to a frequently used dermatological treatment.
January 2024 in “Skin appendage disorders” In this case report, a 31-year-old diabetic and obese male was diagnosed with follicular psoriasis, a rare variant characterized by scaly follicular papules, using dermoscopy and histopathology; treatment with topical mometasone furoate and oral levocetirizine led to complete lesion resolution within a month.
36 citations
,
August 2009 in “PubMed” This article discusses different types of hair loss, their potential causes, and treatment options, but it reports no new clinical findings; the authors emphasize the importance of considering the emotional impact on patients.
April 2026 in “Frontiers in Medicine” This case study reports a 26-year-old male with secondary syphilitic alopecia misdiagnosed as alopecia areata, likely contracted through non-penetrative sexual contact. Effective treatment with intramuscular benzathine penicillin G led to complete hair regrowth within three months.
January 2025 in “NATIONAL BOARD OF EXAMINATIONS JOURNAL OF MEDICAL SCIENCES” This case series reports the specific dermoscopic features observed in two patients with syphilitic alopecia, highlighting alopecic patches with empty hair follicles and other distinguishing characteristics that may aid in differentiating it from other hair disorders.
29 citations
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March 2001 in “Clinics in Dermatology” This article discusses various types of primary cicatricial alopecias and reports no new clinical results; it emphasizes the importance of accurate diagnosis for effective management.
26 citations
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January 2009 in “Annals of Dermatology” This case report describes two instances of rare linear alopecia on the occipital scalp, associated histologically with lupus erythematosus profundus, despite resembling alopecia areata clinically.
8 citations
,
May 2018 in “Primary Care: Clinics in Office Practice” This review details common symptoms of rheumatic diseases and how to differentiate them from other conditions based on patient history and physical examination.