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Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Changing how mesenchymal stromal cells are grown can improve their healing abilities.

The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Targeted cancer therapies often cause serious skin problems that need careful management.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Cancer treatments targeting specific cells and the immune system can cause skin, mouth, hair, and nail problems, affecting patients' quality of life and treatment adherence.

Some medicinal plants can help heal wounds and may lead to new treatments.

Early development of hair, teeth, and glands involves specific signaling pathways and cellular interactions.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Aging causes skin stem cells to work less effectively.

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

Macrophages help heal nerves by aiding the maturation of Schwann cells and are important for nerve repair.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Substances from Chinese medicines show promise for immune support and disease prevention, but the way they are processed affects their effectiveness.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Formyl-peptide receptor agonists could be new anti-inflammatory drugs.

Olive oil compounds may help prevent cancer in animals, but human results are mixed.

MicroRNA-214 is important for skin and hair growth because it affects the Wnt pathway.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.