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    Glossary ERK inhibitors

    drugs that block proteins involved in cell signaling

    ERK inhibitors are drugs or molecules that block the activity of ERK (Extracellular signal-Regulated Kinases), which are proteins involved in sending signals within cells. These signals can control various functions, including cell growth and division. By inhibiting ERK, these drugs can potentially treat conditions like cancer, where cell growth is uncontrolled, or even certain types of hair loss by affecting the pathways that regulate hair follicle activity.

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    1. The antimycotic agent clotrimazole inhibits melanogenesis by accelerating ERK and PI3K-/Akt-mediated tyrosinase degradation Experimental Dermatology · 2015 · 15 citations
    2. VEGF induces proliferation of human hair follicle dermal papilla cells through VEGFR-2-mediated activation of ERK Experimental Cell Research · 2012 · 120 citations
    3. Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632 Frontiers in cell and developmental biology · 2021 · 16 citations
    4. Dihydrotestosterone Induces Keratinocyte Apoptosis by Activating ERK Signaling In Vivo · 2026
    5. Hair Growth Promoting Effects of 15-Hydroxyprostaglandin Dehydrogenase Inhibitor in Human Follicle Dermal Papilla Cells International Journal of Molecular Sciences · 2024
    6. The incidence and management of cutaneous adverse events of the epidermal growth factor receptor inhibitors Postępy Dermatologii i Alergologii · 2017 · 18 citations
    7. [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs Biochemical Pharmacology · 2007 · 26 citations
    8. Hinokitiol, a Natural Tropolone Derivative, Inhibits TNF-α Production in LPS-Activated Macrophages via Suppression of NF-κB Planta Medica · 2008 · 54 citations
    9. Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling Frontiers in bioengineering and biotechnology · 2022 · 8 citations
    10. Antimelanogenic effect of ginsenoside Rg3 through extracellular signal-regulated kinase-mediated inhibition of microphthalmia-associated transcription factor Journal of Ginseng Research · 2015 · 33 citations
    11. 873 The effect of Cilostazol on hair growth: A novel therapeutic option for the treatment of hair loss Journal of Investigative Dermatology · 2017 · 1 citations
    12. Cutaneous Drug Eruptions Associated with the Use of New Oncological Drugs 2012 · 29 citations
    13. 691 Topical curcumin promotes induction of the murine hair cycle 2016 · 3 citations
    14. 546 Epidermal growth factor receptor as a key regulator of the immune privilege Journal of Investigative Dermatology · 2022
    15. When bugs and drugs conspire: driving acneiform skin toxicity 2020 · 1 citations
    16. Sorafenib-induced eruption resembling pityriasis rubra pilaris Journal of the American Academy of Dermatology · 2011 · 21 citations
    17. Cutaneous adverse effects of targeted therapies Journal of the American Academy of Dermatology · 2015 · 149 citations
    18. Udenafil Induces the Hair Growth Effect of Adipose-Derived Stem Cells Biomolecules & Therapeutics · 2019 · 9 citations
    19. Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways Journal of Cellular Biochemistry · 2005 · 24 citations
    20. Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16 Stem Cells and Development · 2016 · 83 citations
    21. Preconditioning with far-infrared irradiation enhances proliferation, cell survival, and migration of rat bone marrow-derived stem cells via CXCR4-ERK pathways Scientific Reports · 2017 · 44 citations
    22. Involvement of Activation of Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway in Proliferation of Urethral Plate Fibroblasts in Finasteride-Induced Rat Hypospadias Medical Science Monitor · 2018 · 10 citations
    23. Wheat Sprout Extract Stimulates Cell Proliferation via Phosphorylation of ERK and Akt in Human Dermal Papilla Cells 2017
    24. 329 Mechanisms of Cutaneous Adverse Events during Targeted Cancer Therapy 2022
    25. Wnt/β-catenin and ERK pathway activation: The possible mechanism of various light-emitting diode light regulates the proliferation of human outer root sheath cells Journal of The American Academy of Dermatology · 2017
    26. Norgalanthamine Stimulates Proliferation of Dermal Papilla Cells <i>via</i> Anagen-Activating Signaling Pathways Biological & Pharmaceutical Bulletin · 2018 · 5 citations
    27. Effect of Puerariae Radix Ethanol Extract on the Proliferation of Human Dermal Papilla Cells Journal of Physiology & Pathology in Korean Medicine · 2017 · 3 citations
    28. Inhibition of TNF-α-Induced Collagen Degradation and Oxidative Damage by Centipeda minima and Brevilin A in Human Dermal Fibroblasts Current Issues in Molecular Biology · 2025 · 1 citations
    29. The Muscarinic Acetylcholine Receptor in Dermal Papilla Cells Regulates Hair Growth International Journal of Molecular Sciences · 2026
    30. 低能量光線對毛囊上皮-間質交互作用的影響:理論與機轉 2009