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![Comments Concerning the Real Risk of Sexual Adverse Events Secondary to the Use of 5-Alpha-Reductase Inhibitors](/images/research/273e930a-50a6-4892-ad73-226287024871/small/18523.jpg)
research Comments Concerning the Real Risk of Sexual Adverse Events Secondary to the Use of 5-Alpha-Reductase Inhibitors
The document concludes that the risk of sexual side effects from 5-alpha-reductase inhibitors is low and often temporary, but more research is needed on potential permanent effects.
![Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People, Version 7](/images/research/0fcaf89e-587b-4457-946d-eaf03d735ba7/small/26813.jpg)
research Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People, Version 7
The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.
![Endocrine Treatment of Transsexual Persons: An Endocrine Society Clinical Practice Guideline](/images/research/8b7c6e9d-179e-4014-a947-0d64b18180f7/small/20381.jpg)
research Endocrine Treatment of Transsexual Persons: An Endocrine Society Clinical Practice Guideline
The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.
![5α-Reductase Activity in the Prostate](/images/research/4425eb71-ee50-4dd6-853e-85ad160f53fc/small/33077.jpg)
research 5α-Reductase Activity in the Prostate
Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.
![Hormesis And Medicine: Biphasic Dose-Response Relationship](/images/research/53541e9d-e23b-44ee-82a2-028b0a0f642c/small/23226.jpg)
research Hormesis And Medicine: Biphasic Dose-Response Relationship
Low doses of some substances can be beneficial, while high doses can be harmful or toxic.
![Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production](/images/research/8104df3a-87cc-4766-ab2e-cf8f061e8a22/small/14634.jpg)
research Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production
Testosterone's muscle-building effects do not require its conversion to DHT.
![A Dubious Equality: Men, Women, and Cosmetic Surgery](/images/research/896ffed4-965b-4ee1-a118-ee2d6acdf463/small/22273.jpg)
research A Dubious Equality: Men, Women, and Cosmetic Surgery
The document concludes that cosmetic surgery is still mainly a practice for women and the gender gap in this field is expected to continue.
![Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology](/images/research/347c282b-b2f7-4f34-91bd-970fcfbcc49c/small/3358.jpg)
research Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology
Finasteride use changes brain chemicals, causing lasting sexual issues and anxiety/depression.
![Red Ginseng Monograph](/images/research/6ff38ca8-2735-47d0-be4b-bf82fcc2b1c4/small/20202.jpg)
research Red Ginseng Monograph
Red ginseng may improve immunity, fatigue, memory, blood circulation, and menopausal symptoms, and is generally safe to consume.
![Sexual Dysfunction in Subjects Treated with Inhibitors of 5α-Reductase for Benign Prostatic Hyperplasia: A Comprehensive Review and Meta-Analysis](/images/research/fd0c19e5-8b97-4efa-b592-679b00730aee/small/13867.jpg)
research Sexual Dysfunction in Subjects Treated with Inhibitors of 5α-Reductase for Benign Prostatic Hyperplasia: A Comprehensive Review and Meta-Analysis
Men taking 5α-reductase inhibitors for enlarged prostate have a higher chance of experiencing reduced sexual desire and erectile dysfunction.
![Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation](/images/research/3a685d52-1486-47be-87c2-ad69e4ff2a63/small/3555.jpg)
research Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation
Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.
![Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients](/images/research/b50e88b2-2332-4df3-88f5-8234a7863456/small/4078.jpg)
research Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients
Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.
![Persistent Erectile Dysfunction in Men Exposed to 5α-Reductase Inhibitors, Finasteride, or Dutasteride](/images/research/f7bafa26-1fd1-4d92-ac8a-5c37a06e10d9/small/4000.jpg)
research Persistent Erectile Dysfunction in Men Exposed to 5α-Reductase Inhibitors, Finasteride, or Dutasteride
Using finasteride or dutasteride may cause long-lasting erectile dysfunction.
![A Novel Finasteride 0.25% Topical Solution for Androgenetic Alopecia: Pharmacokinetics and Effects on Plasma Androgen Levels in Healthy Male Volunteers](/images/research/9363dce3-a9d0-4501-ac51-30766b5a5701/small/3494.jpg)
research A Novel Finasteride 0.25% Topical Solution for Androgenetic Alopecia: Pharmacokinetics and Effects on Plasma Androgen Levels in Healthy Male Volunteers
New finasteride solution effectively reduces baldness-causing hormone, potentially with fewer side effects.
![Treatment of Male Pattern Baldness with Botulinum Toxin: A Pilot Study](/images/research/4a120103-01ee-4299-a15c-8d7a6c91d46f/small/26228.jpg)
research Treatment of Male Pattern Baldness with Botulinum Toxin: A Pilot Study
Botox increased hair count in men with baldness and might work by improving scalp blood flow.
![Kin-Cohort Analysis of LRRK2-G2019S Penetrance in Parkinson's Disease](/images/research/c31384c1-cb33-4413-abd2-12050c1ff724/small/26144.jpg)
research Kin-Cohort Analysis of LRRK2-G2019S Penetrance in Parkinson's Disease
The LRRK2-G2019S mutation in Parkinson's disease has a lifetime penetrance of 25-35%, and finasteride may help reduce symptoms in adult male Tourette syndrome patients.
![A Preliminary Study of Finasteride in Tourette Syndrome](/images/research/c1e2332b-bb2a-4ec1-a25a-91758319e168/small/3082.jpg)
research A Preliminary Study of Finasteride in Tourette Syndrome
Finasteride reduces Tourette syndrome symptoms, but results may be limited due to potential biases.
![Desferrioxamine Treatment of Aceruloplasminemia: Long-Term Follow-Up](/images/research/d1bed812-b9f3-4cf8-a9c2-8e2e54b76b0e/small/26162.jpg)
research Desferrioxamine Treatment of Aceruloplasminemia: Long-Term Follow-Up
Finasteride may help reduce symptoms in male Tourette syndrome patients.
![Efficacy and Side Effects of Drugs Commonly Used for the Treatment of Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia](/images/research/3295f2b3-632b-4cfb-96ec-9343a84216bd/small/17482.jpg)
research Efficacy and Side Effects of Drugs Commonly Used for the Treatment of Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia
Different drugs for prostate-related urinary symptoms work but have various side effects, and treatment should be tailored to the individual.
![One of These Things Is Not Like the Others: The Idea of Precedence in Health Technology Assessment and Coverage Decisions](/images/research/d0ed14ae-d595-4346-82c3-bfd3fdefeaba/small/22152.jpg)
research One of These Things Is Not Like the Others: The Idea of Precedence in Health Technology Assessment and Coverage Decisions
The conclusion is that formalizing how past decisions influence current health technology assessments could improve the credibility and defense of coverage decisions.
![Clinical Features of Familial Lewy Body Parkinsonism Caused by α-Synuclein Triplication (Iowa Kindred) with Video Documentation](/images/research/ee963c44-aab2-4039-88ec-c7f16ff84902/small/26149.jpg)
research Clinical Features of Familial Lewy Body Parkinsonism Caused by α-Synuclein Triplication (Iowa Kindred) with Video Documentation
The document describes a woman with familial Parkinson's disease due to a genetic mutation, showing severe symptoms and poor response to treatment, and suggests finasteride may help reduce symptoms in Tourette syndrome.
![Androgenetic Alopecia as an Early Marker of Benign Prostatic Hyperplasia](/images/research/87339ffe-8383-49ca-bc98-dad1cff7c659/small/3141.jpg)
research Androgenetic Alopecia as an Early Marker of Benign Prostatic Hyperplasia
Early hair loss may indicate prostate issues.
![Revisiting Hyper- and Hypo-Androgenism by Tandem Mass Spectrometry](/images/research/cff39431-3e8c-4c30-94b3-52d8bd56c6df/small/14570.jpg)
research Revisiting Hyper- and Hypo-Androgenism by Tandem Mass Spectrometry
The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.
![Post-Finasteride Syndrome: An Emerging Clinical Problem](/images/research/cd0dcab4-ce97-48b4-886e-892fd2bc58c0/small/4820.jpg)
research Post-Finasteride Syndrome: An Emerging Clinical Problem
Post-finasteride syndrome causes lasting sexual, neurological, and physical side effects in some people after taking finasteride.
![Hormonal and Surgical Treatment Options for Transgender Men (Female-to-Male)](/images/research/0800a9f8-8a31-44f4-aca0-6153823697bf/small/13857.jpg)
research Hormonal and Surgical Treatment Options for Transgender Men (Female-to-Male)
Testosterone therapy and surgeries like mastectomy improve transgender men's lives and mental health with low risks and high satisfaction.
![Testosterone Therapy in Men: Clinical and Pharmacological Perspectives](/images/research/3e7d3ac9-3516-4a83-9487-8807336dc208/small/15520.jpg)
research Testosterone Therapy in Men: Clinical and Pharmacological Perspectives
Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.
![Assessing Finasteride-Associated Sexual Dysfunction Using the FAERS Database](/images/research/2c5d3c51-9ad7-4120-898e-bf20fdba0913/small/4045.jpg)
research Assessing Finasteride-Associated Sexual Dysfunction Using the FAERS Database
Finasteride use linked to increased risk of sexual dysfunction, especially in younger people.
![Consequences of Steroid-5α-Reductase Deficiency and Inhibition in Vertebrates](/images/research/c1133907-1cfc-45ac-977d-db8aa89d2d70/small/12113.jpg)
research Consequences of Steroid-5α-Reductase Deficiency and Inhibition in Vertebrates
Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.
![The Pathophysiology of Delayed Ejaculation](/images/research/5db4c5f4-19c0-4eb5-b9bc-5bab72c5edd1/small/20242.jpg)
research The Pathophysiology of Delayed Ejaculation
Delayed ejaculation is a complex issue caused by psychological, biological, and lifestyle factors, requiring a holistic treatment approach.