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The document concludes that ERBB2 mutations are common in extramammary Paget disease and may respond to systemic treatments like cancer immunotherapy.

CREB, a protein that can promote cancer traits, is controlled by β-catenin in skin cancer cells.

Afatinib, neratinib, and zanubrutinib could be effective against KRASG12C-mutant tumors.

The research provides a gene-based framework for hair biology, highlighting the Hippo pathway's importance and suggesting links between hair disorders, cancer pathways, and the immune system.

The document explains how to create detailed biological pathways using genomic data and tools, with examples of hair and breast development.

Using mesenchymal stem cells or their exosomes is safe for COVID-19 patients and helps improve lung healing and oxygen levels.

Gene therapy shows promise for treating skin disorders and cancer, but faces technical challenges.

Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.

Nanocarriers can improve the effectiveness of herbal medicines in treating colorectal cancer.

Nanomaterials can significantly improve wound healing and future treatments may include smart, real-time monitoring.

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

Male pattern baldness is linked to a higher risk of certain skin cancers, especially on the scalp.

UV photography can help identify people at higher risk for skin cancer, and male pattern baldness at age 45 is linked to a higher risk of certain skin cancers.

High levels of ST14 and TMEFF1 proteins in ovarian cancer are linked to worse patient outcomes and may be a new treatment target.

Some leukemia treatments can cause skin reactions similar to keratosis pilaris.

Hair, teeth, and mammary glands develop similarly at first but use different genes later.

PCOS is a complex disorder in women that can lead to various health risks and requires personalized treatment.

Activating β-catenin in mammary cells leads to changes that cause early-stage abnormal growths similar to skin structures.

Sweat gland development involves two unique skin cell programs and a temporary skin environment.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.

The document concludes that various signaling pathways and genetic factors are crucial for chicken feather development, affecting poultry quality.

Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.

Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.

The research found that male pattern hair loss is mostly genetic and involves hair thinning due to hormonal effects and changes in gene expression.

The study found key factors in the cause of hidradenitis suppurativa, its link to other diseases, and identified existing drugs that could potentially treat it.

The research found that PCOS has common genetic factors regardless of how it is diagnosed and is linked to metabolic and reproductive issues.

Two specific hair keratin genes are active during hair growth and decline as hair transitions to rest.

Certain types of T cells are essential for healthy skin and play a role in skin diseases, but more research is needed to improve treatments.

Neurosteroids change how GABA_A receptors work in the brain, which could be important for treating temporal lobe epilepsy.