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Understanding where cancer cells come from helps create better prevention and treatment methods.

Keratin 17 is modified by RSK1 in response to growth and stress, affecting skin growth and stress response.

Sex hormones affect hair and feather growth and may help manage alopecia and hormone-dependent cancers.

In vivo lineage labelling is better than in vitro methods for identifying and understanding stem cells.

Deleting Smad4 and PTEN genes in mice causes rapid, invasive stomach cancer.

Deleting Smad4 and PTEN genes in mice causes rapid, invasive forestomach cancer.

Flow cytometry was effective in diagnosing metastatic breast cancer in a bone marrow sample.

Disrupting Acvr1b in mice causes severe hair loss and thicker skin.

New findings suggest targeting IL-23 could treat psoriasis, skin cells can adapt to new roles, direct conversion of skin cells to blood cells may aid cell therapy, removing certain tumor cells could boost cancer immunotherapy, and melanoma may have many tumorigenic cells, not just cancer stem cells.

Loss of TET2 increases the risk of skin and oral cancer.

Doxil is an effective, modified chemotherapy drug with a unique toxicity profile and shows promise in treating certain cancers.

β-catenin is essential for stem cell activation and proliferation in hair follicles.

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

Wnt ligands are crucial for hair growth and repair.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

The HR protein's role as a repressor is essential for controlling hair growth.

Improving the environment and cell interactions is key for creating human hair in the lab.

Melanocyte precursors in human fetal skin follow a specific migration pattern and some remain in the skin's deeper layers.

Hair follicle bulge cells don't help skin regrow after glucocorticoid damage; interfollicular epidermis cells do.

The conclusion is that teeth, hair, and claws have similar stem cell niches, which are important for growth and repair, and more research is needed on their regulation and potential markers.

Skin's epithelial stem cells are crucial for repair and maintenance, and understanding them could improve treatments for skin problems.

Adult stem cells with Tp63 can form hair and skin cells when placed in new skin, showing they have hidden abilities for skin repair.

The research suggests that p63 and TGF-β1 may help determine tumor type and malignancy in hair follicle and sebaceous tumors.

The document concludes that recent studies help tell apart desmoplastic trichoepitheliomas from other skin tumors, but more research is needed for clear differentiation.

Too much β-catenin activity can mess up the development of mammary glands and make them more like hair follicles.

A person had two different benign skin tumors, a trichoadenoma and melanocytic naevi, at the same time but in different places on the face.

Benign skin tumors need accurate diagnosis to ensure proper treatment.

The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.