research Activation of the Integrated Stress Response in Human Hair Follicles
Blocking the Mitochondrial Pyruvate Carrier causes stress in hair follicles, which can be reduced by an ISR inhibitor.
Search
for
Sort by
Research
30-60 / 1000+ results research Back to the Future: From Appendage Development Toward Future Human Hair Follicle Neogenesis
New hair follicles could be created to treat hair loss.
research Prolactin: An Emerging Force Along the Cutaneous–Endocrine Axis
Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.
research Revealing Novel Insights on How Oral Supplementation With Collagen Peptides May Prevent Hair Loss: Lessons From the Human Hair Follicle Organ Culture
Collagen peptides from marine and bovine sources may help prevent hair loss by affecting hair follicle stem cells differently.
research Investigation of Glypican-4 and -6 by Infrared Spectral Imaging During the Hair Growth Cycle
Infrared spectral imaging can effectively study protein distribution in hair follicles during hair growth.
research Modeling of Ionizing Radiation Induced Hair Follicle Regenerative Dynamics
Hair follicles can regenerate after radiation damage but not during a specific growth phase.
research Methods in hair research: how to objectively distinguish between anagen and catagen in human hair follicle organ culture
The document discussed the development of a standardized system to distinguish between anagen VI and early catagen stages in human hair follicle organ culture, which was crucial for identifying potential hair growth promoters or inhibitors. Researchers established qualitative and quantitative criteria, including morphological assessments and immunohistochemical markers, to differentiate these stages. Anagen VI hair follicles exhibited a larger hair matrix, more onion-shaped dermal papilla, and higher melanin content, while early catagen follicles had a thinner hair matrix and more oval dermal papilla. Quantitative analysis showed more DAPI+ and Ki-67+ cells in anagen VI follicles, indicating higher proliferation, and more TUNEL+ cells in early catagen follicles, indicating higher apoptosis. The study also explored the effects of eflornithine, a hair growth inhibitor, confirming its ability to impair hair shaft elongation and promote catagen-like regression. This research provided a reliable framework for distinguishing hair cycle stages, enhancing the accuracy and reproducibility of hair follicle assays.
research Do We Need Hair Follicle Stem Cells and Hair Follicle Neogenesis to Cure Common Hair Loss Disorders?
Common hair loss disorders may not need stem cell therapy, but could benefit from other treatments like hair cycle control and immune restoration therapy.
research Harnessing Neuroendocrine Controls of Keratin Expression: A New Therapeutic Strategy for Skin Diseases?
Using neurohormones to control keratin can lead to new skin disease treatments.
research Hair Follicle Transcriptome Analysis Reveals Genes Regulating Wool Fiber Diameter in Angora Rabbits
Genes affecting wool fiber thickness in Angora rabbits were identified, which could help breed finer wool.
research The Pathogenesis of Primary Cicatricial Alopecias
The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.
research Cultured Human and Rat Tooth Papilla Cells Induce Hair Follicle Regeneration and Fiber Growth
Tooth papilla cells can help regenerate hair follicles and grow hair.
research Functional Hair Follicle Regeneration
Scientists made working hair follicles using stem cells, helping future hair loss treatments.
research Molecular Biology of Hair Morphogenesis: Development and Cycling
Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.
research Human Hair Follicles Contain Two Forms of ATP-Sensitive Potassium Channels, Only One Sensitive to Minoxidil
One minoxidil-sensitive potassium channel exists in human hair follicles.
research A Primer for Studying Cell Cycle Dynamics of the Human Hair Follicle
The document concludes that understanding hair follicle cell cycles is crucial for hair growth and alopecia research, and recommends specific techniques and future research directions.
research Protection Against Chemotherapy-Induced Alopecia: Targeting ATP-Binding Cassette Transporters in the Hair Follicle
Increasing ABC transporters in hair follicles may prevent chemotherapy-induced hair loss.
research Hair, Cutaneous Homeostasis, and Stem Cell Functions
Proteins like aPKC and PDGF-AA, substances like adenosine and ATP, and adipose-derived stem cells all play important roles in hair growth and health, and could potentially be used to treat hair loss and skin conditions.
research The Hair Follicle as a Dynamic Mini-Organ
Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
research Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin
Noggin is necessary to start the hair growth phase in skin after birth.
research Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing
The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.
research Principles of Hair Cycle Control
Manipulating the catagen and telogen phases of hair growth could lead to treatments for hair disorders.
research Cyclosporin A-Induced Hair Growth in Mice Is Associated with Inhibition of Calcineurin-Dependent Activation of NFAT in Follicular Keratinocytes
Cyclosporin A helps mice grow hair by blocking a specific protein activity in skin cells.
research A Cell-Based System for Screening Hair Growth-Promoting Agents
Apigenin may help promote hair growth and could treat hair loss.
research Biological Characterization of Cultured Dermal Papilla Cells and Hair Follicle Regeneration In Vitro and In Vivo
Cultured dermal papilla cells can regenerate hair follicles and sustain hair growth.
research Are Hair Follicle Stem Cells Promising Candidates for Wound Healing?
Hair follicle stem cells are promising for wound healing but require more research for safe clinical use.
research Hair in Health and Disease: An Introduction
Hair health depends on various factors and hair loss can significantly affect a person's well-being; understanding hair biology is key for creating effective hair care treatments.
research The Role of Integrin AlphaVbeta6 in Impaired Wound Healing and Hair Follicle Regeneration
Integrin alphavbeta6 is important for wound healing and hair growth, and blocking it may improve these processes.
research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla
Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.
research The Hair Follicle as an Estrogen Target and Source
Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.