Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that incorporating hair follicle-primed spheroids into skin constructs showed potential for developing hair-bearing skin mimetics with follicle-forming abilities in vitro.

This review discusses the molecular mechanisms driving hair follicle degeneration in skin aging and emphasizes the role of the tissue microenvironment on stem cell function, but reports no new research findings.

This review discusses the role of matriptase and its inhibitor HAI-1 in epithelial homeostasis and cancer development, highlighting their imbalance's link to cancer progression without presenting new experimental results.

This study on rats found that finasteride and dutasteride increased collagen density in penile tissues and caused changes in prostate cells, but did not significantly alter erectile pressures compared to controls.

This review synthesizes current evidence on platelet-rich plasma for dry eye disease and reports no new results; the authors emphasize the need for standardized trials to validate these approaches.

This review discusses the human Nude/SCID phenotype and FOXN1 gene's role in immunological disorders affecting T-cell development but reports no new clinical findings.

This study found that differentiated airway epithelial cells can revert into functional stem cells in vivo, suggesting a more general role for this dedifferentiation process in tissue regeneration in higher vertebrates.

This paper discusses the role of Runx1 in epithelial biology and pathology, highlighting its dual function as a tumor promoter and suppressor in different contexts, and reports no new experimental findings.

This study suggests that the interaction between folliculin and plakophilin-4 (p0071) may play a role in folliculin's tumor suppressor function by regulating RhoA signaling, impacting cell migration and junction formation.

This study found that fibronectin is crucial for hair follicle stem cell function and regeneration, with its deletion impairing regeneration but restoration by dermal injection of exogenous fibronectin.

This review summarizes existing knowledge on the role of FOXN1 as a key regulator of thymic epithelial cell lineage and function, reporting no new experimental results.

This study introduces a method using lentiviral delivery in mice to expedite analysis of factors crucial for hair follicle morphogenesis by enabling rapid gain- or loss-of-function studies.

This study suggests that allergens like linalool found in personal care products may contribute to the pathobiology of frontal fibrosing alopecia by affecting immune responses and stem cell function in hair follicles.

In this study, rat primary thymic epithelial cells demonstrated a clonogenic growth pattern in vitro and were able to integrate into functional thymus or differentiate into skin derivatives, similar to skin multipotent stem cells.

In this study, treatment with finasteride altered the expression patterns of antioxidant enzymes in the epididymis of rats, potentially affecting its protective function for spermatozoa.

In this study, researchers developed a novel nucleic acid nanoparticle system incorporating quercetin, which they found enhances functional hair follicle regeneration and maintains epithelial structure stability in androgenetic alopecia by regulating hair follicle stem and dermal papilla cells.

This study reports that KRTAP-like proteins, which resemble keratin-associated proteins found in mammals, are also present in the cornified teeth of various lamprey species, suggesting these proteins may serve similar functions in skin appendages across different vertebrates despite independent evolutionary origins.

This study found that administering calcium blockers verapamil or nimodipine significantly preserved auditory function and hair cell survival in Cx26-cKO mice, suggesting potential protective effects for other inner ear disorders.

This study reports the cloning and expression details of two new human type II keratins, K6irs3 and K6irs4, in the hair follicle's inner root sheath, suggesting a distinct functional role related to hair structure.

This study found that deleting the miRNA processing enzymes Drosha and Dicer from mouse skin epithelial cells disrupted normal hair follicle development and maintenance, leading to follicular degradation and stem cell loss during the growth phase.

This study found that depleting fibroblasts in the skin does not affect the proliferative capacity of epidermal stem cells at various ages, suggesting robust compensatory mechanisms maintain skin functionality despite these cellular changes.

In this review, the authors discuss how SOX9 functions as a key regulator of epithelial cell fate and tissue repair, suggesting its role in integrating environmental signals, which could inform regenerative medicine approaches despite potential risks like fibrosis and cancer.

This study found that an enzymatic digestion method for isolating hair follicle stem cells from scalp specimens yielded 5.3 times more epithelial cells than explant cultures, while supporting comparable cell functionality, offering a promising technique for tissue engineering and regenerative medicine.

This study found that over- and ectopic-expression of FoxN1 in early life negatively affected the development of thymic epithelial cells, T and B cells, and skin epithelial cells.

This study found that finasteride-induced DHT deficiency altered estrogen receptor expression in the epididymis, potentially destabilizing its function.

This study found that both marine and bovine collagen peptides may help prevent hair loss by supporting epithelial hair follicle stem cell functions, with marine peptides maintaining hair in the growth phase and bovine peptides increasing stem cell presence in hair follicle regions.

The research identified six functional hair keratin genes and four pseudogenes, providing insights into hair formation and gene organization.

This review summarizes the cell type distribution and functional significance of human keratins, emphasizing their roles in tumor diagnosis and potential clinical applications, and reports no new clinical findings.

This review discusses the molecular and functional aspects of the nude gene in skin biology, providing insights into its role and evolutionary development, but reports no new results.

This review discusses the role of keratins in maintaining epidermal structure and function and reports no new results; the authors emphasize the lack of rational therapies for skin disorders linked to keratin mutations.