52 citations
,
February 1986 in “Journal of Histochemistry & Cytochemistry” This study found that monoclonal antibodies can identify specific immunological characteristics of hair fibrous proteins, with some antibodies reacting only with hair proteins and others showing broader activity with skin and epithelial cells.
1 citations
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January 2016 in “Methods in molecular biology” This article reviews a new method to accurately estimate proliferative and migratory epithelial cell numbers post-wounding but reports no experimental findings; the authors suggest its relevance to skin stem-cell biology research.
August 2019 in “Journal of Medical Histology” This review discusses the role of epithelial mesenchymal transition (EMT) in wound healing and tissue repair, highlighting its potential contributions to progenitor cell pools, but reports no new clinical findings.
19 citations
,
November 2017 in “General and comparative endocrinology” This study found that BMP2 and BMPR-IA inhibited, while Noggin promoted, hair follicle growth in yaks by affecting skin epithelial cell activity.
2 citations
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March 2019 in “Journal of Histochemistry and Cytochemistry” This study found that NNAT is localized in both undifferentiated and differentiated cells across various rat tissues and has cell-specific intracellular localization, suggesting distinct functional roles.
January 2023 in “Vìsnik problem bìologìï ì medicini” Androgenic alopecia causes hair follicle degradation and skin restructuring, but some hair elements remain.
January 2003 in “Jiefangjun yixue zazhi” In this study, the researchers observed that the expression of certain growth factors and their receptors increases with gestational age, implying a role in skin development, structure maintenance, and wound healing.
11 citations
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September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified a distinct CD49fhigh mesenchymal stem cell subpopulation in the dermis that supports hair follicle development and maintenance via Notch signaling activation.
37 citations
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October 2009 in “Veterinary Dermatology” This study identified and isolated highly proliferative canine keratinocytes in vitro, finding that follicular keratinocytes showed distinct proliferative capacity and marker expression indicative of putative epithelial stem cells.
August 2023 in “Scientific reports” In this study, researchers differentiated human induced pluripotent stem cells into dermal papilla-like cells and observed gene expression dynamics during five stages of dermal differentiation, demonstrating the potential of these cells to interact with epidermal cells in functional assays.
4 citations
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January 2013 in “Stem cell discovery” This study reports the creation of a human dermal mesenchymal-like stem cell line from an androgenetic alopecia patient, which may serve as an in vitro model to explore alopecia mechanisms.
August 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that maintaining a low level of Wnt/β-catenin activity is crucial for mammary gland development, as excessive activity inhibits branching and promotes characteristics of hair follicles instead, highlighting its role in skin appendage identity decisions.
47 citations
,
April 1978 in “Journal of Cutaneous Pathology” This study found that basal cell epithelioma resembles fetal primary epithelial germ based on specific cellular characteristics.
42 citations
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October 2006 in “Theriogenology” Porcine skin cells are useful for studying wound healing and cancer.
1 citations
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January 2017 The document outlines criteria to identify and differentiate neoplasms based on follicular characteristics.
February 2024 in “Biomedical materials” This study developed a new human in vitro hair model that replicates in vivo hair characteristics and may be suitable for high throughput screening of hair growth treatments.
1 citations
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April 2008 in “Experimental Dermatology” This paper reviews hidradenitis suppurativa, comparing its clinical and histopathological characteristics to acne, questioning the proposed link to terminal hair follicles, and reports no new results.
April 2017 in “IOSR journal of dental and medical sciences” This abstract discusses Netherton Syndrome, a genetic disorder with a characteristic triad of symptoms caused by SPINK5 gene mutation, and reports no new clinical findings or treatment advances.
149 citations
,
July 2014 in “Cold Spring Harbor Perspectives in Medicine” This article provides contact information for Bruce A. Morgan and features no new research findings.
71 citations
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October 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” This study presents a novel in vitro assay using human folliculoid microspheres to research hair growth, which may facilitate preclinical testing of hair growth-modulatory agents.
3 citations
,
August 2012 in “Annals of Diagnostic Pathology” This study found that women with AIDS had significantly reduced epithelial thickness and more telogen hair follicles on the scalp compared to women without AIDS.
417 citations
,
September 2005 in “PLoS biology” This study developed molecular signatures for dermal papilla cells and their niche, uncovering novel signaling regulators and genes linked to hair disorders, which may inform future hair development research.
41 citations
,
July 1994 in “Journal of Dermatological Science” This review examines the differentiation potential of epithelial cells from various sources in hair follicle formation, concluding that complex interactions are required for hair-specific characteristics, which were achieved in vivo but not in vitro.
8 citations
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November 2020 in “Nature Communications” This study demonstrates that Tp63-expressing epithelial stem cells from non-skin tissues can respond to skin morphogenetic signals and contribute to the formation of hair follicles, sebaceous glands, and epidermis.
April 2018 in “Journal of Investigative Dermatology” This study found that the loss of transcription factor Ovol2 in epidermal and hair follicle stem cells leads to migration defects, which are partially improved by deleting the EMT-inducing Zeb1.
36 citations
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February 2006 in “Biochemical and Biophysical Research Communications” Wnt-10b helps skin cells develop into hair-related structures.
January 2008 in “Infoscience (Ecole Polytechnique Fédérale de Lausanne)” In this study, rat primary thymic epithelial cells demonstrated a clonogenic growth pattern in vitro and were able to integrate into functional thymus or differentiate into skin derivatives, similar to skin multipotent stem cells.
3 citations
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September 2023 in “Frontiers in immunology” This study discusses the epithelial-immune microenvironment in chronic skin diseases, such as psoriasis and atopic dermatitis, and highlights current and future treatment strategies targeting inflammatory loops within these diseases.
4 citations
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October 2017 in “Advances in tissue engineering & regenerative medicine” In this study, a bioengineered construct using a biodegradable polycaprolactone mat cocultured with human keratinocyte and rabbit dermal fibroblast cells demonstrated potential as a tissue-engineered skin substitute, showing good cell adhesion and growth.
7 citations
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January 1990 in “Archives of Dermatological Research” Syringomas likely start in the upper dermis and form distinct luminal structures.