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This study investigated the epigenetic effects of finasteride on reproductive signaling pathways using Sertoli cell models and found that finasteride exposure led to altered epigenetic profiles in multiple genes, including ESR1 and DNMT3A, indicating potential impacts on reproductive-related pathways.

This literature review highlights recent advancements in hair follicle regeneration techniques, noting the potential of combining stem cell technology, 3D bioprinting, and epigenetic modulation to create precision therapies. However, it emphasizes ongoing challenges such as achieving long-term viability and scalability for clinical application.

This study suggests that finasteride may upregulate BTG2 and CD244 gene expression through differential methylation, indicating potential as a treatment avenue for medulloblastoma.

This experimental study suggests that finasteride may reduce Lymphocyte Specific Protein 1 gene expression through methylation in human Leydig cells, potentially offering a pathway for treating Neutrophil Actin Dysfunction.

This study found that the X-linked gene UTX is crucial for regulating skin differentiation and inflammation in females by affecting retinoic acid signaling, also highlighting potential links to sex disparities in skin diseases.

This article discusses the genomic and postgenomic changes in chronic degenerative diseases and cardiovascular and skin disease contexts, highlighting potential modulation through diet and pharmacological interventions without presenting new experimental results.

This review discusses how urban air pollutants may influence the regulation of JAK3 signaling in alopecia areata and reports no new experimental results; the authors integrate existing data to map potential pathways and biomarkers.

This review discusses epigenetic mechanisms in tissue repair across species and summarizes recent CRISPR-based technologies as promising tools for studying and enhancing tissue regeneration, but reports no new experimental results.

This study investigated the Mandarin duck as a model for understanding lifelong developmental changes, finding that male sail feather morphogenesis involves a combination of local morphogenetic programs, epigenetic regulation, and hormonal cues, with increased female estrogen levels observed before the mating season.

This research discusses the shift in cosmetic dermatology towards integrating regenerative medicine, AI, and personalized care, highlighting their potential to improve aesthetic outcomes and skin function while considering ethical and regulatory challenges.

This study found that aging mice with an epidermal deletion of DNA methyltransferase 1 had a reduced number of hair follicles, due to decreased stem cell activation probability.

This study suggests that HDAC inhibitors, such as Vorinostat and Entinostat, could be effective in promoting hair regrowth in a mouse model of alopecia areata.

This review summarizes recent findings on the role of lactylation, a novel post-translational modification, in skin diseases, suggesting its potential as a therapeutic target by linking metabolism, epigenetic regulation, and inflammatory processes.

CBD can help hair grow by supporting scalp health and reducing inflammation.

This review highlights new perspectives in genomics and epigenomics for skin rejuvenation, comparing innovative strategies like senolytics and DNA repair modulators with classical treatments, and emphasizing the importance of tailoring therapies using individual genomic profiles for personalized anti-ageing approaches.

This review explores the complex causes and treatment options for alopecia, emphasizing that current therapies mainly offer symptomatic relief, while new advancements like stem cell approaches and improved drug delivery systems show promise for addressing underlying disease mechanisms.

This review highlights that alopecia's complex causes include hormonal, genetic, and environmental factors, and discusses traditional and emerging therapies, suggesting a need for multi-targeted, mechanism-based treatments to improve long-term management and efficacy.

This study found that the repressive histone mark H2AK119ub links inhibitory FGF signals with the quiescent state in hair follicle stem cells, revealing a signaling-epigenetic axis crucial for maintaining stem cell quiescence and tissue homeostasis.

This article reviews the role of microRNAs as epigenetic modulators in dermatology but reports no new clinical findings.

This study explored the epigenetic mechanisms of dermal fibroblast progenitor differentiation and found that the repressive chromatin profile from H3K27me3 prevents these progenitors from reforming skin in allograft assays, despite their multipotent potential.

This review highlights the critical role of microRNAs in regulating hair follicle biology, significantly impacting wool and cashmere development by modulating gene expression and signaling pathways in sheep and goats.

This review summarizes the roles of WRKY transcription factors in plant growth and their responses to various environmental stresses, but reports no new experimental findings.

In this study, researchers found that extrafollicular progenitors marked by Hic1 are the main contributors to reparative fibroblasts in wound repair, with potential to modulate healing outcomes through genetic and pharmacological interventions.

This review summarizes recent advances in Treg cell biology, focusing on Foxp3's role in immune regulation and therapeutic reprogramming for immune dysregulatory disorders, but reports no new clinical results.

In this study, researchers identified the miR-22-3p/CLIC4 signaling pathway as a key regulator in hair follicle miniaturization among androgenetic alopecia models, suggesting that targeting CLIC4-mediated sonic hedgehog pathway disruption may offer new therapeutic strategies for AGA treatment.

This review discusses post-finasteride syndrome, emphasizing its serious psychological and cognitive symptoms and the need for more research and awareness in the medical community, but provides no new clinical findings.

This review highlights that the RNA modification N⁶-methyladenosine (m⁶A) plays a crucial role in regulating wound healing and tissue remodeling, with dysregulation contributing to complications in chronic wounds, such as diabetic ulcers and burn injuries, through mechanisms like impaired angiogenesis and increased oxidative stress.

This review discusses the role of epidermal differentiation complex genes and epigenetic mechanisms in skin development and certain diseases, emphasizing their potential for improving drug development and delivery systems but provides no new experimental results.

This review discusses the dynamic changes in chromatin organization and nuclear morphology during cellular processes like differentiation and disease, highlighting recent advances in understanding these epigenetic mechanisms without presenting new experimental findings.

This review discusses the role of the immune niche in hair follicle regeneration and its impact on different forms of alopecia, highlighting research gaps and potential therapeutic strategies.