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Both changes in genes and environmental factors like diet and toxins can significantly affect the growth of skin appendages like hair, but how these factors interact is still unclear.

Finasteride may cause lasting sexual issues by altering specific genes in human cells.

The document concludes that pig iPSCs show promise for transplant therapies and the field is advancing in controlling cell behavior for biology and medicine.

ING5 is crucial for stem cell maintenance and preventing certain cancers.

Finasteride may help treat Neutrophil Actin Dysfunction by reducing LSP1 gene activity.

Diet changes can protect against harmful environmental effects on fetal development.

Aging changes skin cells, leading to different DNA methylation and gene activity, affecting cell metabolism and aging signs.

The study found that p63 needs signals from morphogens to help skin cells differentiate properly.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

Elastic Net DNA methylation clocks are inaccurate for predicting age and health status; a "noise barometer" may better indicate aging and disease.

Epigenetic changes contribute to autoimmune skin diseases.

Genes and epigenetic changes are important in the development of Polycystic Ovary Syndrome.

Colorectal cancer development involves both genetic changes and epigenetic alterations like DNA methylation and microRNA changes.

A mother's diet at conception can cause lasting genetic changes in her child.

Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.

The environment around the time of conception can change the VTRNA2-1 gene in a way that lasts for years and may affect disease risk.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

Minoxidil and Finasteride are effective for male baldness; more research is needed for hair aging treatments.

Alopecia areata is influenced by genetics and immune system factors, and better understanding could improve treatments.

Androgens are important for normal ovarian function and estrogen production, but may not be the main cause of follicle death.

Researchers found 71 genetic regions linked to male pattern baldness, which account for 38% of its genetic risk.

Chromosomal changes, including those in the WRN gene and rDNA, may significantly contribute to aging.

Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.

Mice can grow new hair follicles after skin wounds through a process not involving existing hair stem cells, but requiring more research to understand fully.

High levels of androgens during early development may cause PCOS-like symptoms.

The document concludes that understanding hair follicle cell cycles is crucial for hair growth and alopecia research, and recommends specific techniques and future research directions.

Certain signals are important for reducing specific chemical markers on hair follicle stem cells during rest periods, which is necessary for healthy hair growth.

Finasteride can cause serious side effects in some men, needing more research for treatment.

Gonadal hormones significantly affect the severity of alopecia areata in mice.