10 citations,
July 2022 in “Dermatology and Therapy” Melasma's causes include genetics, sun exposure, hormones, and oxidative stress, and understanding these can help create better treatments.
10 citations,
July 2022 in “Journal of Medicinal Chemistry” Adding a second method to PROTACs could improve cancer treatment.
9 citations,
June 2023 in “Cells” Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.
8 citations,
December 2022 in “Nature Reviews Endocrinology” Sex hormones' effects on COVID-19 are unclear and more research is needed to understand their potential as treatment.
8 citations,
September 2022 in “Human genomics” Key genes and pathways involved in thyroid eye disease were identified, aiding potential treatment and diagnosis.
8 citations,
July 2022 in “International Journal of Molecular Sciences” Skin cells release substances important for healing and fighting infection, and understanding these could improve skin disorder treatments.
7 citations,
March 2023 in “Antioxidants” Rosemary may help treat various skin conditions due to its antioxidant and anti-inflammatory properties.
7 citations,
August 2020 in “Current topics in medicinal chemistry” New cancer treatments aim to reduce side effects and improve effectiveness.
5 citations,
October 2022 in “Cosmetics” Cell-based models help test if cosmetic ingredients really work for hair growth and skin health.
5 citations,
May 2022 in “Diagnostics” The study examined the association of three lncRNA polymorphisms—HOTAIR rs10783618, LINC-ROR rs1942347, and MALAT1 rs3200401—with systemic lupus erythematosus (SLE) in 163 patients and matched controls. It found that HOTAIR rs10783618*C/C and MALAT1 rs3200401*T/T were linked to increased SLE risk, while MALAT1 rs3200401*T/C was associated with decreased risk. HOTAIR rs10783618*C/C was also linked to arthritis and oral ulcers, and rs10783618*T/T was associated with hair loss, weight loss, and neurological symptoms. These findings suggest that HOTAIR and MALAT1 polymorphisms may serve as molecular markers for SLE susceptibility and severity.
5 citations,
October 2021 in “BioMed Research International” Noncrosslinked hyaluronic acid helps human hair cells grow and could be a potential hair loss treatment.
4 citations,
December 2022 in “Frontiers in Bioengineering and Biotechnology” Exosomes show promise for improving wound healing, reducing aging signs, preventing hair loss, and lightening skin but require more research and better production methods.
3 citations,
October 2023 in “Cosmetics” Healthy lifestyle changes can significantly improve skin health as you age.
3 citations,
May 2023 in “Biomedicines” PCOS causes infertility mainly due to hormonal imbalances, insulin resistance, and chronic inflammation.
3 citations,
March 2023 in “International journal of molecular sciences” Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.
3 citations,
April 2022 in “Biomolecules” This study analyzed the association between the microRNA-34a gene (MIR-34A) rs2666433A/G variant and alopecia areata (AA) in 480 participants (240 cases and 240 controls). It found a higher frequency of the A variant in AA patients, with significant associations under various genetic models. Serum miR-34a levels were significantly upregulated in AA patients, especially those with the A/A genotype, and were linked to more severe disease and autoimmune comorbidities like SLE and vitiligo. The study concludes that the MIR34A rs2666433 (A/G) variant and elevated miR-34a levels are associated with increased risk and severity of AA, suggesting miR-34a as a potential molecular marker for AA.
2 citations,
December 2023 in “Pharmaceutics” Inhaling medicine may reduce side effects and improve treatment for a major lung cancer type.
2 citations,
September 2023 in “International journal of molecular sciences” Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.
2 citations,
May 2023 in “Life” Plumbagin may help protect cells, reduce inflammation, and has potential for treating various diseases, but more research is needed.
2 citations,
June 2022 in “International Journal of Molecular Sciences” The study examined the expression of smooth muscle cell-related genes in human dermal sheath cup (DSC) cells and their impact on the outcomes of autologous cell-based therapy for male and female pattern hair loss, involving 32 DSC cell lines from 65 donors. It found that lower levels of smooth muscle cell markers like SRF and CALD1 were associated with better treatment outcomes. CHIR99021 treatment significantly downregulated these markers and upregulated SOX2 and LEF1, suggesting a shift towards dermal papilla cell properties, which are crucial for hair follicle generation. These findings indicate that modulating gene expression in DSC cells could enhance the efficacy of hair loss treatments. Further research with larger sample sizes is needed to validate these results.
1 citations,
March 2024 in “International journal of molecular sciences” Radiation therapy damages skin structure and immune function, causing inflammation and potential hair loss.
1 citations,
November 2023 in “BMC chemistry” Tadalafil and Finasteride may help treat aggressive melanoma.
1 citations,
September 2023 in “Genes” DNA methylation likely doesn't cause different lambskin patterns in Hu sheep.
1 citations,
September 2023 in “Stem cell research & therapy” Mesenchymal stem cells could help treat aging-related diseases better than current methods.
1 citations,
June 2023 in “Cells” Exosomes could be a promising way to help repair skin and treat skin disorders.
1 citations,
May 2023 in “European Journal of Human Genetics” Rare ULBP3 gene changes may raise the risk of Alopecia areata, a certain FAS gene deletion could cause a dysfunctional protein in an immune disorder, and having one copy of a specific genetic deletion is okay, but two copies cause sickle cell disease.
1 citations,
April 2023 in “Frontiers in Immunology” New treatments for hair loss from alopecia areata may include targeting immune cells, using stem cells, balancing gut bacteria, applying fatty acids, and using JAK inhibitors.
1 citations,
April 2023 in “Scientific Reports” Self-assembling RADA16-I hydrogels with bioactive peptides significantly improve wound healing.
1 citations,
April 2023 in “International Journal of Molecular Sciences” New CRISPR/Cas9 variants and nanotechnology-based delivery methods are improving cancer treatment, but choosing the best variant and overcoming certain limitations remain challenges.
1 citations,
January 2023 in “Metabolites” Changes in gut bacteria can contribute to the development of Polycystic Ovary Syndrome (PCOS), affecting metabolism, immunity, and causing inflammation. Treatments may involve adjusting these factors.