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Glossary Epigallocatechin Gallate

powerful antioxidant in green tea with potential hair growth benefits

Epigallocatechin Gallate (EGCG) is a powerful antioxidant found predominantly in green tea. It has been studied for its potential health benefits, including anti-inflammatory, anti-cancer, and heart-protective effects. In the context of hair and alopecia, EGCG has shown promise in promoting hair growth and reducing hair loss by inhibiting the activity of hormones and enzymes that contribute to hair follicle shrinkage.

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research Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG)

108 citations , November 2006 in “Phytomedicine”

This study found that EGCG from green tea may stimulate human hair growth by promoting the proliferation and anti-apoptotic activity in dermal papilla cells.

research Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone-Treated Human Dermal Papilla Cells

16 citations , January 2016 in “Annals of Dermatology”

This study suggests that epigallocatechin gallate (EGCG) from green tea may counteract DHT-induced hair follicle damage by modifying the miRNA expression profile in human dermal papilla cells.

research Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 MKG2D Lymphocytes of Alopecia Areata Patients

15 citations , December 2018 in “International journal of environmental research and public health/International journal of environmental research and public health”

This study observed that Epigallocatechin-3-gallate (EGCG) can inhibit phosphorylation of STAT1 and reduce a specific subset of immune cells in vitro and ex vivo, suggesting a potential role in maintaining immune privilege in alopecia areata.

Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways

research Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways

14 citations , June 2018 in “Frontiers in pharmacology”

In this study, EGCG from green tea promoted mink hair follicle growth and cell proliferation at specific concentrations, potentially through activation of Shh and AKT signaling pathways.

Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles

research Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles

7 citations , July 2022 in “Pharmaceutics”

This study found that a dissolvable microneedle device delivering rapamycin and epigallocatechin gallate nanoparticles significantly enhanced hair regrowth in C57BL/6 mice within 7 days, demonstrating increased hair shaft growth and follicle density with minimal inflammation compared to untreated mice.

research Long-Term Preservation of Rat Skin Tissue by Epigallocatechin-3-O-Gallate

6 citations , May 2009 in “Cell transplantation”

This study found that EGCG improved the integrity of skin grafts during cryopreservation, suggesting its potential usefulness for skin preservation, though the exact mechanism remains unclear.

research Epigallocatechin-Gallate (EGCG): An Essential Molecule for Human Health and Well-Being

4 citations , September 2025 in “International Journal of Molecular Sciences”

This review discusses the dermatological applications and potential health benefits of Epigallocatechin-gallate (EGCG) from green tea, but provides no new clinical findings.

research Electronic States of Epigallocatechin-3-Gallate in Water and in 1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (Sodium Salt) Liposomes

3 citations , January 2025 in “International Journal of Molecular Sciences”

In this study, researchers investigated EGCG's spectroscopic properties and its interaction with DPPG lipid, finding that both experimental and theoretical approaches agree on the electronic transitions and reveal an increased absorbance due to molecular interactions.

Epigallocatechin-3-Gallate Inhibits Paclitaxel-Induced Apoptosis Through the Alteration of MicroRNA Expression in Human Dermal Papilla Cells

research Epigallocatechin-3-gallate inhibits paclitaxel-induced apoptosis through the alteration of microRNA expression in human dermal papilla cells

3 citations , January 2018 in “Biomedical dermatology”

This study found that epigallocatechin-3-gallate (EGCG) may reduce paclitaxel-induced apoptosis in human dermal papilla cells by regulating microRNA expression related to apoptosis and cell proliferation.

research Antiaging Effect of Tea Epigallocatechin Gallate and Its Role in Modifying Aging Epigenetics: A Systematic Review

1 citations , January 2023 in “Pharmacophore”

This review examines the role of Epigallocatechin Gallate in aging epigenetics but reports no new research findings.

Design and Development of Epigallocatechin Gallate and Fenugreek Seed Extract Loaded Nanosponge-Based Aloe Vera Gel for Treating Alopecia Areata

research Design and development of Epigallocatechin gallate and Fenugreek seed extract loaded Nanosponge based Aloevera gel for treating Alopecia Areata

June 2026 in “International Journal of Drug Delivery Technology”

This study developed EGCG-loaded nanohydrogels using ethyl cellulose and polyvinyl alcohol to enhance the stability and delivery of the hydrophilic drug in aloe vera gel, optimizing encapsulation efficiency and drug release properties.

research Formulation and Optimization Spanlastic Gel Loaded Epigallocatechin Gallate for Transdermal Delivery

April 2026 in “JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA”

In this study, the researchers successfully developed a Spanlastic gel containing EGCG for transdermal application, significantly increasing EGCG skin permeability with optimal entrapment efficiency, zeta potential, and vesicle size.

research (−)-Epigallocatechin-3-gallate promotes the dermal papilla cell proliferation and migration through the induction of VEGFA

January 2025 in “Biochimica et Biophysica Acta (BBA) - Molecular Cell Research”

This study found that EGCG, a compound from green tea, may enhance the proliferation and antioxidant activity of dermal papilla cells by upregulating VEGFA expression, potentially aiding hair follicle growth.

research Role of epigallocatechin-3-gallate from green tea in iron chelation and endoplasmic reticulum stress pathway in colorectal cancer cells

December 2018

This study found that in vitro, EGCG may help treat colorectal cancer by targeting iron chelation and the ER stress pathway, leading to apoptosis in cancer cells while sparing normal cells.

Epigallocatechin Gallate and Tannic Acid Based Formulations of Finasteride for Dermal Administration and Chemoembolization

research Paper 2. Epigallocatechin Gallate and Tannic Acid Based Formulations of Finasteride for Dermal Administration and Chemoembolization

October 2020 in “Journal of Pharmaceutical Sciences”

This study found that using gallate-containing formulations like EGCG or tannic acid increased the solubility and controlled release of finasteride in microspheres, enhancing its dermal penetration in pig skin by 10 to 50 times compared to a control.

research Electronic States of Epigallocatechin-3-Gallate in Water and in 1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (Sodium Salt) Liposomes

February 2025 in “Universidade Nova de Lisboa's Repository (Universidade Nova de Lisboa)”

This research discusses various collaborative and funding efforts across multiple institutions but does not present new experimental findings.

research Food Bioactive Compounds and Emerging Techniques for Their Extraction: Polyphenols as a Case Study

188 citations , December 2020 in “Foods”

This review explores the potential health benefits of food bioactive compounds, specifically polyphenols, as preventive agents against non-communicable diseases like cancer and cardiovascular disorders, while also addressing challenges like bioavailability and industrial applications.

research Green tea: Health benefits

86 citations , January 2008 in “Journal of nutritional & environmental medicine”

This review examines the health benefits of green tea, focusing on catechins, but reports no new findings; the authors emphasize potential benefits for conditions like cancer, heart disease, and diabetes.

research Nutraceuticals as anti-angiogenic agents: hopes and reality.

48 citations , March 2005 in “PubMed”

This paper reviews the potential of various bioactive plant compounds, including resveratrol and curcumin, for modulating angiogenesis but presents no new clinical results.

research The secretory clear cell of the eccrine sweat gland as the probable source of excess sweat production in hyperhidrosis

36 citations , August 2011 in “Experimental Dermatology”

In this study, researchers found no hypertrophy in axillary sweat glands of hyperhidrotic patients, with eccrine gland clear cells being the primary site of fluid transport and no evidence of apoeccrine glands.

research Green tea in dermatology - myths and facts

20 citations , July 2015 in “Journal der Deutschen Dermatologischen Gesellschaft”

This review summarizes the anticarcinogenic, anti-inflammatory, and other health effects of green tea, noting its historical and ongoing use in dermatological and cosmeceutical applications, but reports no new clinical results.

research Use of natural molecules as anti-angiogenic inhibitors for vascular endothelial growth factor receptor

16 citations , December 2012 in “Bioinformation”

This study suggests that natural molecules like curcumin, EGCG, barringtozenol, and finasteride may be effective inhibitors for VEGFR, potentially offering a cancer chemoprevention alternative to pazopanib.

research Effects of topical application of EGCG on testosterone-induced hair loss in a mouse model

14 citations , July 2011 in “Experimental Dermatology”

In this study, topical EGCG significantly reduced testosterone-induced hair loss and follicular apoptosis in mice, without altering testosterone or dihydrotestosterone concentrations.

research Development and Characterization of Dual-Loaded Niosomal Ion-Sensitive In Situ Gel for Ocular Delivery

4 citations , December 2024 in “Gels”

This study observed that a dual-loaded niosomal in situ gel delivered effective antimicrobial and antioxidant properties for potential ophthalmic applications, showing superior inhibition of methicillin-resistant Staphylococcus aureus adhesion.

Injectable Gelatin/Metal/Tea Polyphenol Double Nanonetworks for Diabetic Wound Healing

research Facile General Injectable Gelatin/Metal/Tea Polyphenol Double Nanonetworks Remodel Wound Microenvironment and Accelerate Healing

4 citations , December 2023 in “Advanced science”

This study found that injectable gelatin/metal/tea polyphenol double nanonetworks significantly accelerated wound healing in diabetic wounds by enhancing cell migration and providing anti-inflammatory and antioxidant properties, without detectable cytotoxicity in tests.

research Green Tea Extract: A Novel Addition to the Antihirsutism Armamentarium?

3 citations , June 2009 in “The journal of alternative and complementary medicine/Journal of alternative and complementary medicine”

This letter discusses the potential of green tea extract as a treatment for hirsutism but reports no clinical outcomes.

research Role and Mechanisms of Phytochemicals in Hair Growth and Health

2 citations , January 2023 in “Pharmaceuticals”

This review discusses factors affecting hair health, types of alopecia, and the potential of phytochemicals in managing hair loss but reports no new clinical results; it highlights the need for further studies.

An Uncontrolled Case Series Using a Botanically Derived, β-Cyclodextrin Inclusion Complex in Two Androgenetic Alopecia-Affected Male Subjects

research An Uncontrolled Case Series Using a Botanically Derived, β-Cyclodextrin Inclusion Complex in Two Androgenetic Alopecia-Affected Male Subjects

2 citations , August 2020 in “Cosmetics”

This study reported unexpected positive results in two males with androgenetic alopecia using a cyclodextrin-enabled, natural-based formula over 270 days, showing marked hair thickening and reduced scalp hair loss.

research Hair Root Activation by Anagen Grow- A Herbal Hair Growth Serum

2 citations , February 2019 in “JOJ dermatology & cosmetics”

The study found that Anagen grow, a herbal serum, promotes hair growth elongation and may inhibit the alpha reductase enzyme, suggesting it as a safe, effective alternative to finasteride and beneficial alongside minoxidil for reducing scalp dryness.

Discovering the Potential of Natural Remedies in Post COVID-19 Complications Based on In Silico Techniques

research Discovering the potential of natural remedies in the post COVID-19 complications based on in silico techniques

June 2022 in “Organic communications”

This study explores potential treatments for post COVID-19 complications using natural substances through molecular docking, but reports no new clinical results and existing treatments remain limited to prophylaxis and therapeutics.