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Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

Dermal adipose tissue in mice can change and revert to help with skin health.

Targeting TGFβ can improve skin immunity in older people.

Hair quality is genetically determined and linked to its composition and strength.

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

Rabbits lacking the Hoxc13 gene show similar hair and skin issues to humans with ECTD-9, making them good for research on this condition.

Some skin diseases and their treatments can negatively affect male fertility.

Skin health and diseases are closely linked to metabolic processes.

Testosterone, progesterone, and levonorgestrel change enzyme levels related to fat production in hamster skin, which could affect skin oil and acne.

Finding functions for unknown GPCRs is hard but key for making new drugs.

Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

More PDCD4 is linked to obesity, insulin problems, and cell death in ovaries for those with polycystic ovary syndrome.

Puerariae Flos extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.

Dihydrotestosterone (DHT) stops hair growth in mice by lowering a growth factor important for hair.

Infertile men are more likely to produce sperm with abnormal chromosome numbers, which can affect pregnancy success and embryo health.

Some growth factors, while important for normal body functions, can cause diseases when not regulated properly.

Wait 3 months after COVID-19 before trying assisted reproduction and further research is needed on COVID-19's effects on male hormones and fertility.

The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.

Finasteride safely treats hair loss without harming hormones or reproduction, but may slightly reduce sexual function.

Testosterone is crucial for development, growth, and various body functions in mammals.

Environmental factors and exposure to toxins may contribute to male infertility by affecting sperm and hormone function.

High levels of cortisol in hair show long-term stress which can lower fertility in animals.

The dog's skin condition improved after removing a tumor that was causing hormone imbalances.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Androgens, like testosterone, are crucial for early testicular descent in rats.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.