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    Glossary Epidermis

    outermost skin layer providing protection against environmental factors

    The epidermis is the outermost layer of the skin, serving as a protective barrier against environmental factors such as pathogens, UV radiation, and physical injury. It is composed of multiple layers of cells, primarily keratinocytes, which undergo a continuous process of renewal and shedding. This layer also contains melanocytes, which produce melanin, the pigment responsible for skin color.

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    1. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000 · 1010 citations
    2. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009 · 503 citations
    3. Defining stem cell dynamics and migration during wound healing in mouse skin epidermis Nature Communications · 2017 · 363 citations
    4. Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis Development · 2009 · 338 citations
    5. Transient activation of β-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours Development · 2004 · 335 citations
    6. Different keratin polypeptides in epidermis and other epithelia of human skin: a specific cytokeratin of molecular weight 46,000 in epithelia of the pilosebaceous tract and basal cell epitheliomas. The Journal of Cell Biology · 1982 · 277 citations
    7. The epidermis: rising to the surface Current opinion in genetics & development · 1994 · 238 citations
    8. Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis Proceedings of the National Academy of Sciences of the United States of America · 2012 · 221 citations
    9. Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter Journal of Investigative Dermatology · 2000 · 215 citations
    10. Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation. The Journal of Cell Biology · 1989 · 198 citations
    11. GLI2 Is Expressed in Normal Human Epidermis and BCC and Induces GLI1 Expression by Binding to its Promoter Journal of Investigative Dermatology · 2004 · 171 citations
    12. Rac1 Is Crucial for Hair Follicle Integrity but Is Not Essential for Maintenance of the Epidermis Molecular and Cellular Biology · 2006 · 139 citations
    13. Overexpression of protein kinase C-α in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation and COX-2, MIP-2 and TNF-α expression but not tumor promotion Journal of Cell Science · 1999 · 135 citations
    14. Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals Proceedings of the National Academy of Sciences · 2005 · 130 citations
    15. Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled EMBO journal · 2002 · 127 citations
    16. Expression of μ-Opiate Receptor in Human Epidermis and Keratinocytes Journal of Investigative Dermatology · 1998 · 111 citations
    17. Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation Molecular and cellular biology · 2002 · 108 citations
    18. Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion. PubMed · 2000 · 99 citations
    19. The Human Hair Follicle: A Reservoir of CD40+ B7-Deficient Langerhans Cells that Repopulate Epidermis After UVB Exposure 1998 · 99 citations
    20. Size-dependent penetration of nanoemulsions into epidermis and hair follicles: implications for transdermal delivery and immunization Oncotarget · 2017 · 96 citations
    21. Actinic keratosis: a clinical and epidemiological revision Anais Brasileiros de Dermatologia · 2012 · 89 citations
    22. The mouse keratin 6 isoforms are differentially expressed in the hair follicle, footpad, tongue and activated epidermis Differentiation · 1999 · 75 citations
    23. Epidermal growth factor delays the development of the epidermis and hair follicles of mice during growth of the first coat The Anatomical Record · 1983 · 72 citations
    24. Secreted subtilisin Sub3 from <i>Microsporum canis</i> is required for adherence to but not for invasion of the epidermis 2009 · 63 citations
    25. Electron Microscope Studies of the Human Epidermis The Clear Cell of Masson (Dendritic Cell or Melanocyte) The Journal of Cell Biology · 1958 · 56 citations
    26. Trichohyalin: Presence in the Granular Layer and Stratum Corneum of Normal Human Epidermis 1991 · 48 citations
    27. Homeostasis, regeneration and tumour formation in the mammalian epidermis The International Journal of Developmental Biology · 2018 · 44 citations
    28. Ectopic<i>Atoh1</i>expression drives Merkel cell production in embryonic, postnatal and adult epidermis Development · 2015 · 41 citations
    29. Modulation of the differentiated phenotype of keratinocytes of the hair follicle and from epidermis Journal of Dermatological Science · 1994 · 41 citations
    30. Ephrins Negatively Regulate Cell Proliferation in the Epidermis and Hair Follicle Stem Cells · 2010 · 39 citations