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    Glossary Epidermal Morphogenesis

    process of skin layer formation and development

    Epidermal morphogenesis refers to the process by which the outermost layer of the skin, known as the epidermis, forms and develops its structure during embryonic development and wound healing. This involves the coordinated proliferation, differentiation, and organization of skin cells to create a functional barrier that protects the body from environmental damage.

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    1. H3K9me3 controls epidermis morphogenesis by regulating RNA Pol II dynamics at developmental promoters and enhancers Nature Communications · 2026
    2. Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair EMBO journal · 1999 · 204 citations
    3. Micropatterned dermal–epidermal regeneration matrices create functional niches that enhance epidermal morphogenesis Acta Biomaterialia · 2013 · 65 citations
    4. Author response: NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures 2016 · 3 citations
    5. Expression of retinoic acid receptors and dermal-epidermal interactions during mouse skin morphogenesis 1992 · 3 citations
    6. Bone morphogenetic protein signaling drives rete ridge morphogenesis: a distinct epidermal appendage program Signal Transduction and Targeted Therapy · 2026
    7. Effect of thyroid hormone and epidermal growth factor on tactile hair development and craniofacial morphogenesis in the postnatal rat. PubMed · 1987 · 10 citations
    8. α-parvin is required for epidermal morphogenesis, hair follicle development and basal keratinocyte polarity PloS one · 2020 · 7 citations
    9. Impaired Hair Follicle Morphogenesis and Cycling with Abnormal Epidermal Differentiation in nackt Mice, a Cathepsin L-Deficient Mutation American Journal Of Pathology · 2002 · 57 citations
    10. Conversion of the Nipple to Hair-Bearing Epithelia by Lowering Bone Morphogenetic Protein Pathway Activity at the Dermal-Epidermal Interface ˜The œAmerican journal of pathology · 2008 · 41 citations
    11. Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis Matrix Biology · 2016 · 19 citations
    12. Hair follicle morphogenesis and epidermal homeostasis in we/we wal/wal mice with postnatal alopecia Histochemistry and Cell Biology · 2014 · 7 citations
    13. ASH2L mediates epidermal differentiation and hair follicle morphogenesis via H3K4me3 modification 2024
    14. Decision letter: NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures 2015
    15. Disrupted Ectodermal Organ Morphogenesis in Mice with a Conditional Histone Deacetylase 1, 2 Deletion in the Epidermis Journal of Investigative Dermatology · 2013 · 32 citations
    16. P63 expression pattern during rat epidermis morphogenesis and the role of p63 as a marker for epidermal stem cells Journal of Cutaneous Pathology · 2006 · 16 citations
    17. GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells 2008 · 39 citations
    18. The Wave complex controls epidermal morphogenesis and proliferation by suppressing Wnt–Sox9 signaling The Journal of Cell Biology · 2019 · 22 citations
    19. Retinoic Acid and Mouse Skin Morphogenesis. II. Role of Epidermal Competence in Hair Glandular Metaplasia Developmental Biology · 1994 · 16 citations
    20. α3β1-integrin regulates hair follicle but not interfollicular morphogenesis in adult epidermis Journal of Cell Science · 2003 · 45 citations
    21. Wound Regeneration Deficit in Rats Correlates with Low Morphogenetic Potential and Distinct Transcriptome Profile of Epidermis Journal of Investigative Dermatology · 2018 · 21 citations
    22. Epidermal Wnt/beta-catenin signalling promotes dermal adipocyte differentiation during hair follicle morphogenesis and regeneration Journal of Dermatological Science · 2012
    23. 918 Skin morphogenesis by coupling biochemical-bioelectric signals: Calcium oscillations coordinate dermal cell movement by epidermis-derived SHH signaling during feather bud orientation Journal of Investigative Dermatology · 2019
    24. Expression of laminin, type IV collagen and fibronectin molecules is related to embryonal skin and epidermal appendage morphogenesis. PubMed · 2001 · 10 citations
    25. p63 regulates <i>Satb1</i> to control tissue-specific chromatin remodeling during development of the epidermis The Journal of Cell Biology · 2011 · 166 citations
    26. A new look into an old problem: keratins as tools to investigate determination, morphogenesis, and differentiation in skin. Genes & Development · 1989 · 156 citations
    27. Molecular biology of hair morphogenesis: Development and cycling Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution · 2003 · 155 citations
    28. TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis The EMBO Journal · 2011 · 91 citations
    29. Dermal-epidermal interactions Clinics in dermatology · 1988 · 65 citations
    30. Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10–p63 axis in epithelial homeostasis Proceedings of the National Academy of Sciences · 2017 · 59 citations