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    Did you mean Epidermal Homeostasis?
    Glossary Epidermal Homeostasis

    balanced renewal of skin cells maintaining skin's protective function

    Epidermal homeostasis refers to the balanced state of the outermost layer of the skin, where old skin cells are continuously shed and replaced by new ones. This process ensures that the skin remains healthy, resilient, and capable of performing its protective functions. For professionals, it involves a complex interplay of cellular proliferation, differentiation, and apoptosis, regulated by various signaling pathways and environmental factors.

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    Research 30 of 1000+

    1. Epidermal homeostasis: a balancing act of stem cells in the skin Nature Reviews Molecular Cell Biology · 2009 · 1039 citations
    2. Cell Density-Dependent Upregulation of PDCD4 in Keratinocytes and Its Implications for Epidermal Homeostasis and Repair International Journal of Molecular Sciences · 2015 · 10 citations
    3. Hair follicle epithelial stem cells contribute to interfollicular epidermis during homeostasis JCI Insight · 2025 · 1 citations
    4. 855 Targeted deletion of crif1 in mouse skin epidermis impairs skin homeostasis Journal of Investigative Dermatology · 2017
    5. 852 Targeted deletion of crif1 in mouse skin epidermis impairs skin homeostasis Journal of Investigative Dermatology · 2017
    6. Recent advances in the epidermal growth factor receptor/ligand system biology on skin homeostasis and keratinocyte stem cell regulation Journal of Dermatological Science · 2013 · 97 citations
    7. Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis Cell death and differentiation · 2011 · 76 citations
    8. Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10–p63 axis in epithelial homeostasis Proceedings of the National Academy of Sciences · 2017 · 59 citations
    9. Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity Nature Communications · 2019 · 38 citations
    10. The regulation of skin homeostasis, repair and the pathogenesis of skin diseases by spatiotemporal activation of epidermal mTOR signaling Frontiers in Cell and Developmental Biology · 2022 · 35 citations
    11. Activated Kras Alters Epidermal Homeostasis of Mouse Skin, Resulting in Redundant Skin and Defective Hair Cycling Journal of Investigative Dermatology · 2010 · 29 citations
    12. Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance 2016 · 26 citations
    13. Identification of novel glucocorticoid receptor-regulated genes involved in epidermal homeostasis and hair follicle differentiation The Journal of Steroid Biochemistry and Molecular Biology · 2007 · 19 citations
    14. Laminin 332 Is Indispensable for Homeostatic Epidermal Differentiation Programs 2021 · 12 citations
    15. Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin International journal of molecular sciences · 2021 · 9 citations
    16. Hair follicle morphogenesis and epidermal homeostasis in we/we wal/wal mice with postnatal alopecia Histochemistry and Cell Biology · 2014 · 7 citations
    17. Regulation of Epidermal Ferritin Expression Influences Systemic Iron Homeostasis Journal of Investigative Dermatology · 2023 · 6 citations
    18. SPT6 maintains epidermal homeostasis by inhibiting an NF-κB-positive feedback loop to prevent excessive inflammation Cellular and Molecular Immunology · 2026
    19. AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis 2024
    20. AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2023
    21. Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis 2023
    22. Reviewer #3 (Public Review): Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis 2023
    23. Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis 2023
    24. Reviewer #2 (Public Review): Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis 2023
    25. Reviewer #4 (Public Review): Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis 2023
    26. Reviewer #1 (Public Review): Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis 2023
    27. eLife assessment: Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis 2023
    28. The Role of EAAT4 in Epidermal Differentiation and Calcium Homeostasis during Aging 2023
    29. 1336 The de novo DNA methyltransferase DNMT3A is required for epidermal homeostasis Journal of Investigative Dermatology · 2018
    30. Role of alkaline ceramidase 1 (Acer1) in regulating epidermal homeostasis and tumorigenesis Academic Commons (Stony Brook University) · 2017