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    Glossary Epidermal

    outermost skin layer

    "Epidermal" refers to anything related to the epidermis, which is the outermost layer of the skin. This layer serves as a protective barrier against environmental damage, pathogens, and water loss. In the context of hair and alopecia, the health of the epidermal layer can influence hair growth and scalp conditions.

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    1. Epidermal homeostasis: a balancing act of stem cells in the skin Nature Reviews Molecular Cell Biology · 2009 · 1039 citations
    2. Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation. Genes & Development · 1991 · 409 citations
    3. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011 · 396 citations
    4. 40nm, but not 750 or 1,500nm, Nanoparticles Enter Epidermal CD1a+ Cells after Transcutaneous Application on Human Skin 2006 · 323 citations
    5. Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting Journal of controlled release · 2005 · 297 citations
    6. The circadian molecular clock creates epidermal stem cell heterogeneity Nature · 2011 · 293 citations
    7. Expression of epidermal keratins and filaggrin during human fetal skin development. The Journal of Cell Biology · 1985 · 292 citations
    8. Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development Science Signaling · 2013 · 277 citations
    9. Epidermal Notch signalling: differentiation, cancer and adhesion Current opinion in cell biology · 2008 · 253 citations
    10. Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure. The EMBO Journal · 1995 · 252 citations
    11. Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes Molecular and Cellular Biology · 2006 · 226 citations
    12. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing Cell Reports · 2018 · 209 citations
    13. Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair EMBO journal · 1999 · 204 citations
    14. Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation The Journal of Cell Biology · 2001 · 195 citations
    15. Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility 2009 · 189 citations
    16. Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment Development · 2003 · 182 citations
    17. Lack of the Vitamin D Receptor is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth 2002 · 180 citations
    18. Follicular and epidermal alterations in patients treated with ZD1839 (Iressa), an inhibitor of the epidermal growth factor receptor 2002 · 169 citations
    19. Epidermal stem cell diversity and quiescence EMBO molecular medicine · 2009 · 168 citations
    20. Human dermal stem cells differentiate into functional epidermal melanocytes Journal of Cell Science · 2010 · 164 citations
    21. Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster. Proceedings of the National Academy of Sciences · 1984 · 164 citations
    22. An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation. Proceedings of the National Academy of Sciences of the United States of America · 1996 · 154 citations
    23. Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell? Cell Stem Cell · 2007 · 153 citations
    24. Age-associated inflammation inhibits epidermal stem cell function Genes & development · 2012 · 144 citations
    25. Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties Nature cell biology · 2017 · 143 citations
    26. 25 Hydroxyvitamin D 1 α-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis 2004 · 140 citations
    27. Classification and management of skin, hair, nail and mucosal side-effects of epidermal growth factor receptor (EGFR) inhibitors European journal of cancer · 2007 · 138 citations
    28. The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling Development · 2011 · 134 citations
    29. Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors Proceedings of the National Academy of Sciences of the United States of America · 2014 · 130 citations
    30. Epidermal stem cells in wound healing and their clinical applications Stem Cell Research & Therapy · 2019 · 129 citations