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    Glossary Epidermal Turnover

    process of shedding old skin cells and generating new ones

    Epidermal Turnover, also known as Skin Cell Turnover or Skin Renewal, is the process by which the skin continuously sheds old, dead cells and replaces them with new, healthy ones. This cycle typically takes about 28 days in a healthy adult, but can vary based on factors like age, skin type, and overall health. This process is crucial for maintaining skin health, as it helps to repair damage, maintain a youthful appearance, and protect against environmental stressors.

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    1. LB1077 Cutaneous responses to systemic iron: A potential role for epidermal turnover in mammalian iron excretion Journal of Investigative Dermatology · 2019
    2. Evaluation of Hair Cycle and Epidermal Turnover. Nishi Nihon hifuka · 2001
    3. LB1081 Three-dimensional imaging of tight junction-network across multiple layers of human epidermis by array tomography using backscattered electron-mode scanning electron microscopy Journal of Investigative Dermatology · 2019
    4. Kajian Efektivitas Penggunaan Zinc Pyrithione dalam Sediaan Sampo Antiketombe Prosiding Farmasi · 2020
    5. 560 The molecular mechanism of PCE-DP, a novel brightening active ingredient Journal of Investigative Dermatology · 2019
    6. Bulge Progenitor Cells: A Promising Frontier in Hair Follicle Regeneration and Clinical Translation Stem Cell Reviews and Reports · 2026
    7. 464 Spatial transcriptomics links gene expression profiles to functional and structural traits of darkly pigmented skin Journal of Investigative Dermatology · 2025
    8. 1430 Autophagy controls the protein composition of hair shafts Journal of Investigative Dermatology · 2023
    9. Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 7 citations
    10. Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis 2023
    11. TCDD-induced activation of aryl hydrocarbon receptor regulates the skin stem cell population Medical hypotheses · 2015 · 9 citations
    12. Epidermal homeostasis: a balancing act of stem cells in the skin Nature Reviews Molecular Cell Biology · 2009 · 1039 citations
    13. Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2023
    14. A bio-polymeric scaffold incorporated with p-Coumaric acid enhances diabetic wound healing by modulating MMP-9 and TGF-β3 expression Colloids and surfaces. B, Biointerfaces · 2023 · 1 citations
    15. The Effect of Ruby Laser Light on Cellular Proliferation of Epidermal Cells Annals of Plastic Surgery · 1999 · 9 citations
    16. Development and Homeostasis of the Skin Epidermis Cold Spring Harbor perspectives in biology · 2012 · 85 citations
    17. Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding niche Nature Reviews Molecular Cell Biology · 2013 · 133 citations
    18. The histopathologic spectrum of psoriasis Clinics in Dermatology · 2007 · 111 citations
    19. Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation European journal of cell biology · 2004 · 36 citations
    20. Anatomy and Physiology of the Skin Journal of the Dermatology Nurses’ Association · 2011 · 277 citations
    21. Functional analysis of the stratum corneum of scalp skin: studies in patients with alopecia areata and androgenetic alopecia Archives of Dermatological Research · 2000 · 52 citations
    22. Keratin expression in basal cell carcinomas British Journal of Dermatology · 1992 · 128 citations
    23. Stem Cells and their Niches Journal of Investigative Dermatology · 2013 · 1 citations
    24. LB1076 Using the frog embryonic epidermis as a model to study desmosome function during development Journal of Investigative Dermatology · 2019
    25. The regeneration of caudal epidermal specializations inLygodactylus picturatus keniensis (gekkonidae, Lacertilia) Journal of Morphology · 1971 · 26 citations
    26. CD4 expression controls epidermal stem cell balance Scientific Reports · 2025 · 1 citations
    27. Age-associated inflammation inhibits epidermal stem cell function Genes & development · 2012 · 144 citations
    28. Upregulation of interfollicular epidermal and hair infundibulum β-catenin expression in Gsdma3 mutant mice Acta histochemica · 2012 · 11 citations
    29. Characterization of Primary Cilia and Intraflagellar Transport 20 in the Epidermis 2020 · 1 citations
    30. 1336 The de novo DNA methyltransferase DNMT3A is required for epidermal homeostasis Journal of Investigative Dermatology · 2018