research A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis
Inhibiting ODC can prevent UV-induced skin cancer.
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research A Non-Cell Autonomous Dermal Hedgehog Signaling Mechanism for Follicular Neoplasia and Induction
Mutations in the SHH pathway in certain skin cells can cause skin tumors and abnormal hair growth.
research Heterogeneity of Ornithine Decarboxylase Expression in 12-O-Tetradecanoylphorbol-13-Acetate-Treated Mouse Skin and in Epidermal Tumors
ODC expression in mouse skin and tumors is varied and can be inhibited by retinoic acid or cycloheximide.
research Histopathological Study of Epithelial, Melanocytic and Adnexal Tumors of Skin: A Retrospective Study in a Tertiary Care Centre
Most skin tumors in the study were benign, with squamous cell carcinoma being the most common malignant type.
research Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity
Activating β-catenin in different skin stem cells causes various types of hair growth and skin tumors.
research Epidermal Abnormalities and Increased Malignancy of Skin Tumors in Human Epidermal Keratin 8-Expressing Transgenic Mice
Mice with human skin protein K8 had more skin problems and cancer.
research Ornithine Decarboxylase Overexpression Is a Sufficient Condition for Tumor Promotion in Mouse Skin
High levels of ornithine decarboxylase can cause tumors in mouse skin.
research The Malignant Capacity of Skin Tumors Induced by Expression of a Mutant H-Ras Transgene Depends on the Cell Type Targeted
The risk of skin tumors becoming malignant depends on the specific skin cell type affected.
research Growing an Epidermal Tumor
The glucocorticoid receptor helps protect skin from tumors and other issues.
research Benign Skin Tumors: Overview, Clinical Features, Histopathology, and Treatment Options
Benign skin tumors need accurate diagnosis to ensure proper treatment.
research Sox9 Expression in Canine Epithelial Skin Tumors
Sox9 is present in most canine skin tumors and may help understand stem cells' role in these cancers.
research Bone Morphogenetic Proteins and Their Antagonists in Skin and Hair Follicle Biology
Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.
research A Desmosomal Cadherin Controls Multipotent Hair Follicle Stem Cell Quiescence and Orchestrates Regeneration Through Adhesion Signaling
A protein called desmoglein 3 is important for keeping hair follicle stem cells inactive and helps in their regeneration.
research Indian Hedgehog Controls Proliferation and Differentiation in Skin Tumorigenesis and Protects Against Malignant Progression
Indian Hedgehog helps control skin cell growth and protects against aggressive skin cancer.
research Effects of Visible Light on the Skin
Visible light can damage skin and most sunscreens don't block it well; more research is needed on its effects and protection methods.
research Role of Stem Cells in Skin Maintenance, Regeneration, and Repair: Focus on Epidermis and Pilosebaceous Units
The document concluded that stem cells are crucial for skin repair, regeneration, and may help in developing advanced skin substitutes.
research 25 Years of Epidermal Stem Cell Research
Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.
research Age-Associated Inflammation Connects RAS-Induced Senescence to Stem Cell Dysfunction and Epidermal Malignancy
Older skin has higher cancer risk due to inflammation and stem cell issues.
research Direct Cellular Reprogramming Enables Development of Viral T Antigen-Driven Merkel Cell Carcinoma in Mice
Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.
research PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells
PTEN helps control the number and health of skin stem cells by working with the protein BMAL1.
research C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny
c-Myc activation in mouse skin increases sebaceous gland growth and affects hair follicle development.
research All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration
The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.
research Urticaria, Drug Hypersensitivity Rashes, Nodules and Tumors, and Atrophic Diseases
The document concludes that various skin conditions have specific treatments, ranging from antihistamines for urticaria to surgery and medication for tumors and chronic skin diseases.
research Patched1 Functions as a Gatekeeper by Promoting Cell Cycle Progression
Patched1 helps prevent tumors by controlling cell growth.
research Targeted Expression of Spermidine/Spermine N1-Acetyltransferase Increases Susceptibility to Chemically Induced Skin Carcinogenesis
Increasing SSAT makes skin more prone to cancer.
research Solitary Pedunculated Multicystic Viral Plaque Associated with Canine Papillomavirus 18 in a British Bulldog
A British Bulldog had a unique viral plaque caused by Canine papillomavirus 18, different from typical tumors.
research K6/ODC Transgenic Mice as a Sensitive Model for Carcinogen Identification
K6/ODC transgenic mice are effective for quickly identifying cancer-causing chemicals.
research Hair Follicle Disruption Facilitates Pathogenesis to UVB-Induced Cutaneous Inflammation and Basal Cell Carcinoma Development in Ptch+/- Mice
Damaged hair follicles make mice more prone to skin inflammation and skin cancer after UV exposure.
research Stem Cell Heterogeneity and Plasticity in Epithelia
Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.
research ST14 Interacts With TMEFF1 and Is a Predictor of Poor Prognosis in Ovarian Cancer
High levels of ST14 and TMEFF1 proteins in ovarian cancer are linked to worse patient outcomes and may be a new treatment target.