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GlossaryEpidermal Hyperplasia (epidermal thickening)

abnormal increase in skin cell layers, causing thickened skin

Epidermal Hyperplasia, also known as epidermal thickening, is a condition where the outer layer of the skin (epidermis) undergoes an abnormal increase in the number of cells, leading to a thicker skin layer. This can be a response to chronic irritation, inflammation, or certain skin disorders, and may present as rough, scaly patches on the skin. For professionals, it is important to note that this condition can be indicative of underlying issues such as psoriasis or chronic eczema.

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Overexpression of Activin A in the Skin of Transgenic Mice Reveals New Activities in Epidermal Morphogenesis, Dermal Fibrosis, and Wound Repair

research Overexpression of Activin A in the Skin of Transgenic Mice Reveals New Activities in Epidermal Morphogenesis, Dermal Fibrosis, and Wound Repair

204 citations, October 1999 in “EMBO journal”

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

Adult Epidermal Notch Activity Induces Dermal Accumulation of T Cells and Neural Crest Derivatives Through Upregulation of Jagged 1

research Adult Epidermal Notch Activity Induces Dermal Accumulation of T Cells and Neural Crest Derivatives Through Upregulation of Jagged 1

34 citations, November 2010 in “Development”

Activating Notch in adult skin causes T cells and neural crest cells to gather, leading to skin issues.

research Laminin 332 Is Indispensable for Homeostatic Epidermal Differentiation Programs

12 citations, May 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

Laminin 332 is essential for normal skin cell behavior and structure.

research P120-Catenin Regulates Epidermal Inflammation in a Cadherin-Dependent Manner

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

p120-catenin helps control skin inflammation by regulating cadherin levels.

research Regulation of Epidermal Proliferation and Hair Follicle Cycling by Synthetic Photostable Retinoid EC23

January 2023 in “Journal of cosmetic dermatology”

The synthetic retinoid EC23 thickens skin and promotes hair growth more effectively and with a lower dose than natural retinoids.

research Alpha-Parvin Is Required for Epidermal Morphogenesis, Hair Follicle Development, and Basal Keratinocyte Polarity

7 citations, March 2020 in “PloS one”

α-parvin is necessary for skin and hair growth and for the correct orientation of skin cells.

research Physiological and Retinoid-Induced Proliferations of Epidermis Basal Keratinocytes Are Differently Controlled

127 citations, July 2002 in “EMBO journal”

Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.

research Inactivation of the Vitamin D Receptor Enhances Susceptibility of Murine Skin to UV-Induced Tumorigenesis

148 citations, October 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mice without the vitamin D receptor are more prone to UV-induced skin tumors.

Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes

research Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes

81 citations, September 2005 in “The American journal of pathology”

Activin helps skin growth and healing mainly through stromal cells and affects keratinocytes based on its amount.

Impact of Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma and Activated Platelet-Rich Plasma in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

research Impact of Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma and Activated Platelet-Rich Plasma in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

58 citations, January 2020 in “International Journal of Molecular Sciences”

Different methods of preparing Platelet-Rich Plasma (PRP) can affect wound healing and hair regrowth in plastic surgery. Using a kit with specific standards helps isolate PRP that meets quality criteria. Non-Activated PRP and Activated PRP have varying effects depending on the tissue and condition treated. For hair regrowth, Non-Activated PRP increased hair density more than Activated PRP. Both treatments improved various aspects of scalp health.

research Physiological Doses of Red Light Induce IL-4 Release in Cocultures Between Human Keratinocytes and Immune Cells

9 citations, August 2017 in “Photochemistry and Photobiology”

Red light at 627 nm can safely trigger IL-4 release in skin cells, potentially helping treat inflammatory skin conditions.

research Case Report: Kerion Celsi Effectively Treated with Terbinafine. Characteristics of Kerion Celsi in the Elderly in Japan

6 citations, November 1999 in “Mycoses”

A man in Japan got better from a scalp fungal infection using terbinafine.

research Dynamic Evaluation of Pathological Changes in a Mouse Acne Model by Optical Imaging Technology

2 citations, May 2023 in “Experimental dermatology”

New imaging techniques can assess and track changes in mouse acne without harm, aiding treatment choices.

research Artificial Infestation of Sarcoptes Scabiei in Rabbits Exhibits Progressive Pathological Changes, Apoptosis, and Keratinization in the Skin

1 citations, January 2023 in “International journal of molecular sciences”

Rabbits with Sarcoptes scabiei had thicker skin, cell death, and skin hardening.

research Ichthyosis Fetalis in a Cross-Bred Lamb

1 citations, June 2017 in “Veterinary dermatology”

A cross-bred lamb with severe skin and movement issues had ichthyosis fetalis but normal vitamin A levels.

research Molecular and Pathological Studies on Sarcoptes Scabiei in Sheep in Ismailia Province, Egypt

August 2020 in “Egyptian Veterinary Medical Society of Parasitology Journal (EVMSPJ)”

10.5% of sheep in Ismailia, Egypt, had Sarcoptes scabiei, causing skin issues.

research Laminin-511 Is a New Player in the Development of Psoriasis and Controlled via Cannabinoid Receptor Type 1

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

Laminin-511 is involved in psoriasis development and can be regulated by cannabinoid receptor type 1.

research Anti-Wrinkle Effect of Bone Morphogenetic Protein Receptor 1a Extracellular Domain (BMPR1a-ECD)

5 citations, September 2013 in “BMB Reports”

BMPR1a-ECD reduces wrinkles much more effectively than retinoic acid.

research Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles

94 citations, February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

EGF makes hair follicles grow longer but stops hair production.

research Development of a Novel In Vitro Strategy to Understand the Impact of Shaving on Skin Health: Combining Tape Strip Exfoliation and Human Skin Equivalent Technology

November 2023 in “Frontiers in Medicine”

The method effectively mimics shaving damage on skin for testing skincare products.

research Erlotinib-Induced Skin Inflammation Is IL-1 Mediated in KC-Tie2 Mice and Human Skin Organ Culture

15 citations, October 2014 in “The journal of investigative dermatology/Journal of investigative dermatology”

Erlotinib causes skin inflammation through IL-1, which can be reduced by anakinra.

research Abnormal Wool Growth and Alopecia of Artificially Reared Lambs

9 citations, January 1981 in “Australian journal of biological sciences”

Lambs fed a liquid diet showed abnormal wool and skin, which improved with more B-vitamins, suggesting a link to B-vitamin deficiency.

research Immunohistochemical Expression of Keratins in Normal Ovine Skin and in Chronic Dermatitis Due to Sarcoptes Scabiei

2 citations, February 2021 in “Journal of comparative pathology”

Sheep with chronic Sarcoptes scabiei dermatitis have altered keratin expression in their skin.

research Topical Olive Oil With Downregulation of Stress Factors Protects Mice Skin From Precarious 3600 MHz Electromagnetic Radiation

March 2020 in “The Egyptian Journal of Histology”

Topical olive oil protects mice skin from harmful electromagnetic radiation.

research Dermal EZH2 Simultaneously Orchestrates Wnt/β-Catenin Signaling Dependent Dermal Differentiation and Retinoic Acid Signaling Dependent Epidermal Proliferation During Murine Skin Development

November 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Ezh2 controls skin development by balancing signals for dermal and epidermal growth.