211 citations,
May 2018 in “Trends in cell biology” Different types of skin cells play specific roles in development, healing, and cancer.
1 citations,
November 2022 in “Journal of Investigative Dermatology” ALRN-6924 may prevent hair loss caused by chemotherapy.
2 citations,
May 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Sebaceous glands can heal and regenerate after injury using their own stem cells and help from hair follicle cells.
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November 2018 in “Physiological Reviews” The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
508 citations,
February 2007 in “Cell” Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.
35 citations,
August 2021 in “npj Regenerative Medicine” Fibroblasts, cells usually linked to tissue repair, also help regenerate various organs and their ability decreases with age. Turning adult fibroblasts back to a younger state could be a new treatment approach.
359 citations,
January 2015 in “Cold Spring Harbor Perspectives in Medicine” Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.
July 2024 in “Journal of Nanobiotechnology” Mouse cell exosomes help hair regrowth and wound healing by activating a specific signaling pathway.
March 2024 in “Bioactive Materials” New treatment using engineered nanovesicles in hydrogel improves hair growth by repairing hair follicle cells in a mouse model of hair loss.
57 citations,
April 2009 in “Differentiation” SDF-1/CXCL12 and its receptor CXCR4 are crucial for melanocyte movement in mouse hair follicles.
15 citations,
July 2013 in “Cell Reports” Indian Hedgehog helps control skin cell growth and protects against aggressive skin cancer.
64 citations,
November 2012 in “EMBO reports” Lamins are vital for cell survival, organ development, and preventing premature aging.
July 2024 in “Journal of Investigative Dermatology” A single medium, PRIME AIRLIFT, supports better human hair follicle formation in grafts.
May 2024 in “Journal of functional foods” Coffee bean residue extract helps hair growth by activating cell processes.
January 2022 in “Aesthetic surgery journal” Extracellular vesicles may effectively treat hair loss with minimal side effects.
26 citations,
July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” The protein Par3 is crucial for healthy skin, affecting the skin barrier, cell differentiation, and stem cell maintenance.
1 citations,
January 2019 in “Advances in stem cells and their niches” Epidermal stem cells are crucial for skin health and problems with them can cause issues like poor wound healing, cancer, and aging.
293 citations,
November 2011 in “Nature” The circadian clock affects skin stem cell behavior, impacting aging and cancer risk.
September 2016 in “Journal of dermatological science” Epidermal stem cells use integrin β1 and α6 as markers and CD271+ cells help maintain skin health and heal wounds.
168 citations,
August 2009 in “EMBO molecular medicine” Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.
72 citations,
July 2012 in “Journal of Investigative Dermatology” Mice lacking a key DNA methylation enzyme in skin cells have a lower chance of activating stem cells necessary for hair growth, leading to progressive hair loss.
13 citations,
July 2020 in “World journal of stem cells” Vitamin D and calcium are important for skin stem cell function and wound healing.
4 citations,
January 2013 in “Advances in Experimental Medicine and Biology” Certain transcription factors are key in controlling skin stem cell behavior and could impact future treatments for skin repair and hair loss.
22 citations,
June 2017 in “Stem cell reports” PTEN helps control the number and health of skin stem cells by working with the protein BMAL1.
72 citations,
November 2017 in “Journal of developmental biology” The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.
153 citations,
October 2007 in “Cell Stem Cell” New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.
61 citations,
September 2008 in “Stem Cells” Most hair follicle stem cells do not protect their DNA by dividing it unevenly.
January 2019 in “Advances in stem cells and their niches” Skin health and repair depend on the signals between skin stem cells and their surrounding cells.
23 citations,
November 2018 in “Development, Growth & Differentiation” Epidermal stem cells have various roles in skin beyond just maintenance, including forming specialized structures and aiding in skin repair and regeneration.
19 citations,
October 2007 in “Wound Repair and Regeneration” Epidermal stem cells maintain skin health through specific niches and signaling pathways.