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    Did you mean Epidermal Homeostasis?
    Glossary Epidermal Homeostasis

    balanced renewal of skin cells maintaining skin's protective function

    Epidermal homeostasis refers to the balanced state of the outermost layer of the skin, where old skin cells are continuously shed and replaced by new ones. This process ensures that the skin remains healthy, resilient, and capable of performing its protective functions. For professionals, it involves a complex interplay of cellular proliferation, differentiation, and apoptosis, regulated by various signaling pathways and environmental factors.

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    1. Recent advances in the epidermal growth factor receptor/ligand system biology on skin homeostasis and keratinocyte stem cell regulation Journal of Dermatological Science · 2013 · 97 citations
    2. Pgc-1α controls epidermal stem cell fate and skin repair by sustaining NAD+ homeostasis during aging Molecular Metabolism · 2022 · 22 citations
    3. Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance 2016 · 26 citations
    4. An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis Development · 2004 · 99 citations
    5. Investigating the role of notch ligands regulating epidermal stem cell differentiation eScholarship@McGill (McGill) · 2025
    6. Sphingolipid metabolism orchestrates the establishment of the adult hair follicle stem cell niche to control skin homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2024
    7. Faculty Opinions recommendation of Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2013
    8. Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate International Journal of Molecular Sciences · 2018 · 57 citations
    9. Single cell transcriptomics of human epidermis reveals basal stem cell transition states bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 5 citations
    10. The circadian molecular clock creates epidermal stem cell heterogeneity Nature · 2011 · 293 citations
    11. Hair follicle epithelial stem cells contribute to interfollicular epidermis during homeostasis JCI Insight · 2025 · 1 citations
    12. Ceramide Synthase 4 Regulates Stem Cell Homeostasis and Hair Follicle Cycling Journal of Investigative Dermatology · 2015 · 53 citations
    13. Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin Cold Spring Harbor Perspectives in Medicine · 2014 · 96 citations
    14. TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis The EMBO Journal · 2011 · 91 citations
    15. POLYCOMB REPRESSIVE COMPLEX 1 IS REQUIRED TO MAINTAIN STEM CELL IDENTITY AND TO PRESERVE ADULT TISSUE HOMEOSTASIS. Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · 2020
    16. Analysis on the maintenance mechanisms of human interfollicular epidermal stem cell and their niche Journal of dermatological science · 2016
    17. PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells Stem cell reports · 2017 · 22 citations
    18. Epidermal stem cell lineages Advances in stem cells and their niches · 2019 · 1 citations
    19. Phospholipase C 1 is required for skin stem cell lineage commitment The EMBO Journal · 2003 · 101 citations
    20. Hair follicle morphogenesis and epidermal homeostasis in we/we wal/wal mice with postnatal alopecia Histochemistry and Cell Biology · 2014 · 7 citations
    21. A single type of progenitor cell maintains normal epidermis Yearbook of Dermatology and Dermatologic Surgery · 2008
    22. Stem Cell Heterogeneity and Plasticity in Epithelia Cell Stem Cell · 2015 · 129 citations
    23. Characterisation of CD4+ stem cells of the skin and their role in skin homeostasis and tumourigenesis 2021 · 1 citations
    24. WIF1 Is Expressed by Stem Cells of the Human Interfollicular Epidermis and Acts to Suppress Keratinocyte Proliferation Journal of Investigative Dermatology · 2013 · 18 citations
    25. Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer Journal of developmental biology · 2017 · 72 citations
    26. Vitamin D and calcium signaling in epidermal stem cells and their regeneration World journal of stem cells · 2020 · 13 citations
    27. The Role of ATP-dependent Chromatin Remodeling in the Control of Epidermal Differentiation and Skin Stem Cell Activity Stem cell biology and regenerative medicine · 2018
    28. What does the concept of the stem cell niche really mean today? BMC biology · 2012 · 163 citations
    29. Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis Nature communications · 2022 · 7 citations
    30. Hair Follicle Stem Cell SLC3A2 Regulates Epithelial Regenerative Properties Journal of Investigative Dermatology · 2025