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    Glossary Epidermal Permeability Barrier

    outermost skin layer preventing water loss and blocking pathogens

    The Epidermal Permeability Barrier is a critical function of the outermost layer of the skin, known as the stratum corneum. It prevents excessive water loss from the body and protects against the entry of harmful substances and microorganisms. This barrier is maintained by a complex mixture of lipids, proteins, and other molecules that work together to keep the skin hydrated and intact.

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    1. Delayed epidermal permeability barrier formation and hair follicle aberrations in Inv-Cldn6 mice Mechanisms of development · 2005 · 63 citations
    2. Does dry skin indicate defective epidermal permeability barrier? Chinese Journal of Dermatology · 2022
    3. Epidermal Vascular Endothelial Growth Factor Production Is Required for Permeability Barrier Homeostasis, Dermal Angiogenesis, and the Development of Epidermal Hyperplasia American Journal Of Pathology · 2008 · 100 citations
    4. Overexpression of the calcium sensing receptor accelerates epidermal differentiation and permeability barrier formation in vivo Mechanisms of Development · 2003 · 46 citations
    5. 25 Hydroxyvitamin D 1 α-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis 2004 · 140 citations
    6. 2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation Toxicological sciences · 2011 · 86 citations
    7. Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production Journal of Investigative Dermatology · 2019 · 40 citations
    8. The Fate of Epidermal Tight Junctions in the stratum corneum: Their Involvement in the Regulation of Desquamation and Phenotypic Expression of Certain Skin Conditions International Journal of Molecular Sciences · 2022 · 11 citations
    9. 856 Topical application of newly developed pseudoceramide improved both skin and hair barrier functions Journal of Investigative Dermatology · 2017
    10. Epidermal pigmentation in the human lineage is an adaptation to ultraviolet radiation 2013 · 62 citations
    11. Phylogeny of the Hair Follicle: The Sebogenic Hypothesis Journal of Investigative Dermatology · 2007 · 21 citations
    12. 피부장벽, 이온, 사이토카인 한국피부장벽학회지 · 2009
    13. The fatty acids and the skin: a focus on the n-6 family of unsaturated fatty acids Human health handbooks · 2012 · 1 citations
    14. The Endocrine Function of the Skin: An Analytical Narrative Apollo medicine · 2023
    15. Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation The Journal of Cell Biology · 2001 · 195 citations
    16. Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction Journal of Cell Science · 2009 · 87 citations
    17. Disturbed Epidermal Structure in Mice with Temporally Controlled Fatp4 Deficiency 2005 · 39 citations
    18. “Structural imprinting” of the cutaneous immune effector function Tissue Barriers · 2020 · 4 citations
    19. The Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss Scientific Reports · 2017 · 19 citations
    20. Epidermal Barrier Cosmetic Dermatology · 2022
    21. Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation Journal of Allergy and Clinical Immunology · 2019 · 34 citations
    22. Sebaceous Gland, Hair Shaft, and Epidermal Barrier Abnormalities in Keratosis Pilaris with and without Filaggrin Deficiency ˜The œAmerican journal of pathology · 2015 · 23 citations
    23. Obesity resistance of the stearoyl-CoA desaturase-deficient (<i>scd1</i> <sup>-/-</sup>) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation Biological Chemistry · 2007 · 87 citations
    24. The role of Glucosylceramides in Keratinocyte Differentiation and Epidermal Barrier Function 2013 · 1 citations
    25. The acyl-CoA binding protein is required for normal epidermal barrier function in mice Journal of Lipid Research · 2012 · 31 citations
    26. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity The Journal of Cell Biology · 2015 · 98 citations
    27. Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin International journal of molecular sciences · 2021 · 9 citations
    28. Multiple Roles of Integrin-Linked Kinase in Epidermal Development, Maturation and Pigmentation Revealed by Molecular Profiling PLOS ONE · 2012 · 9 citations
    29. Radiation Dermatitis: Radiation-Induced Effects on the Structural and Immunological Barrier Function of the Epidermis International journal of molecular sciences · 2024 · 1 citations
    30. Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development Frontiers in Cell and Developmental Biology · 2020 · 12 citations