Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review highlights recent advances in understanding how the extracellular matrix regulates epidermal stem cell fate, emphasizing the importance of the hair follicle stem cell niche, but reports no new empirical findings.

Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.

In this study, expressing human K16 in the epidermis of K14 null mice prevented early skin blistering but led to age-related anomalies, indicating K16 and K14 have distinct roles despite their sequence similarity.

This study found that androgen receptor activation in adult mouse skin reduces β-catenin-induced hair follicle growth and sebaceous gland conversion, highlighting its role in stem cell fate decisions.

This study demonstrates that transfected epidermal stem cells using a novel 3D transfection system significantly enhanced wound healing and may serve as an effective therapeutic agent and gene delivery method for wound treatment.

This study reported that disrupting ephrin-Eph interactions in adult mouse skin doubled cell proliferation in the hair follicle and epidermis, suggesting ephrins as negative regulators of proliferation.

This study found that Par3 plays a crucial role in maintaining epidermal homeostasis by regulating Rho/actomyosin contractility and ensuring mitotic accuracy, with potential implications for other self-renewing epithelia.

This study found that locally injected zalutumumab in healthy volunteers induced a papulopustular rash similar to systemic EGFR inhibitors, and that IL-8 inhibition reduced this dermatological side effect.

The researchers reported that in hairless mice, epidermal cell division orientations and epidermal thickness varied by body site, with dorsal and ear epidermis primarily dividing parallel to the basement membrane, unlike hind paw and tail epidermis.

This study demonstrates that incorporating human neopapilla into reconstructed human skin can initiate hair follicle morphogenesis by stimulating epidermal invagination and maintaining follicle-inductive properties in vitro.

This study reports that transplantation of an ESCs-collagen-chitin biomimetic membrane leads to successful in situ skin regeneration, including hair follicle cell proliferation and formation of dermatoglyphs, in nude mice with full-thickness skin defects.

This study observed that selectively activating activin in the epidermis of mice enhanced reepithelialization during wound healing without altering the quality of the healed wound.

This review highlights similarities in the development of thymus and skin epidermis, reporting no new results; the authors emphasize shared molecular mechanisms despite different embryonic origins.

This review discusses the identification and roles of different epidermal stem cell types in skin homeostasis and repair, and reports no new experimental findings.

This review discusses how epidermal Langerhan's cells and dermal cells may influence keratinocyte environments, potentially aiding in the formation of stem cell niches and cellular variety in the basal layer, without providing novel results.

This study found that using a non-invasive multielectrode array for gene electrotransfer in hairless guinea pigs increased gene expression in the epidermis significantly, with minimal skin changes observed.

In this study, CD109 overexpression in transgenic mice led to reduced inflammation and improved collagen organization during wound healing without affecting wound closure.

This study found that 5% primed conditioned medium from human umbilical cord blood-derived mesenchymal stromal cells significantly improved hair density, thickness, and growth rate in patients with androgenetic alopecia.

This study found that deletion of c-Jun and JunB in mouse bulge hair follicle stem cells was sufficient to trigger psoriasis-like skin disease through thymic stromal lymphopoietin signaling.

This study indicates that transient Msx2 expression is critical for wound-induced hair follicle neogenesis, with distinct phases in the healing process essential for epidermal competence and hair regeneration.

This review discusses how inflammation influences hair follicle stem cell activities like wound healing and follicle cycling and suggests a potential link between inflammation, stem cell activation, and programmed cell death.

This review discusses the adverse skin effects of EGFR inhibitors used in cancer treatment, exploring their mechanisms and offering strategies for prevention and management, but reports no new experimental findings.

This review discusses the role of vitamin D metabolism in skin immunity and wound healing but does not present new results, highlighting the need for further research into its therapeutic applications.

This review discusses the early phases of melanomagenesis and the factors influencing melanoma cell variability and reports no new clinical results.

This study found that quiescent bulge stem cells, when prevented from contributing to hair follicle and epidermal regeneration, did not affect hair follicle growth or wound healing in the short term.

This study found that the PP2A-B55α regulatory subunit is crucial for ectodermal development in mice, with knockout embryos displaying severe neural and epidermal defects and failing to survive to birth.

This study found that CD26+ fibroblasts are crucial for effective extracellular matrix production and achieving rapid epidermal and dermal homeostasis in human tissue-engineered skin substitutes transplanted onto rodents.

This study found that epidermal stem cell-specific Jag1 expression levels are crucial for effective wound healing and scar reduction, and porcine acellular dermal matrix treatment enhances this process in mice by boosting Notch/Jagged1 signaling.

This study suggests that PDCD4 regulates keratinocyte proliferation and contact inhibition, playing a role in epidermal homeostasis and wound healing.

This article reviews recent research on adult epidermal stem cells, discussing their properties and potential for reprogramming into patient-specific therapies, and emphasizes the need for further development while minimizing cancer risk.