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Certain chemicals cause hair graying in black mice but not yellow mice.

Skin aging is a complex process influenced by various factors, leading to wrinkles and sagging, and should be considered a disease due to its health impacts.

Patient-derived melanocytes can potentially treat vitiligo by restoring skin pigmentation.

P-cadherin is crucial for hair follicle pigmentation but not skin pigmentation.

Silencing certain circadian clock genes increases skin pigmentation.

Collagen XVII is crucial for skin cell growth and nail health.

Epidermal stem cells show promise for future dermatology treatments due to ongoing advancements.

BMP signaling is important for skin color, affecting melanin production, pigment spread, and cell movement.

The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.

Skin grafting can help repigment vitiligo, but it's less effective for widespread cases due to the Koebner phenomenon.

Certain immune system proteins are important for skin healing but can cause problems if there are too many of them.

The extracellular matrix is crucial for controlling skin stem cell behavior and health.

Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.

Activating Notch in adult skin causes T cells and neural crest cells to gather, leading to skin issues.

The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.

Estrogen is important for keeping adult mouse nipple skin healthy by controlling certain cell signals.

Hair follicle stem cells help skin heal and grow during stretching.

AP-2α and AP-2β proteins are essential for healthy adult skin and hair.

Alopecia areata may be linked to hearing problems, so patients should monitor their hearing.

Melanocyte transplantation can safely restore skin color, especially in stable vitiligo, but must be chosen carefully based on the disease phase.

The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.

The Wnt/β-catenin pathway can activate melanocyte stem cells and may help regenerate hair follicles.

Radiation mainly affects keratinocyte stem cells, not melanocyte stem cells, causing hair to gray.

Gonadal hormones significantly affect the severity of alopecia areata in mice.

The research found a way to identify and study skin cells with stem cell traits, revealing they behave differently in culture and questioning current stemness assessment methods.

The research found ways to activate melanocyte stem cells for potential treatment of skin depigmentation conditions.

Lenalidomide helps hair follicle stem cells turn into melanocytes, which may improve repigmentation in vitiligo.

The gene Tfap2b is essential for creating a type of stem cell in zebrafish that can become different pigment cells.

Activating β-catenin increases melanocytes and decreases Schwann cells.

Hair growth-related cells need the enzyme SCD1 to help maintain the area that supports hair growth.